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学科主题: 药物依赖
题名:
Cross-sensitization of the reinforcing effects of cocaine and amphetamine in rats
作者: Liu, Yu; Morgan, Drake; Roberts, David C. S.
关键词: motivation ; sensitization ; tolerance ; stimulants ; reinforcement
刊名: PSYCHOPHARMACOLOGY
发表日期: 2007-12-01
DOI: 10.1007/s00213-007-0909-6
卷: 195, 期:3, 页:369-375
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: RECEPTOR-DEPENDENT MANNER ; NUCLEUS-ACCUMBENS ; PREVIOUS EXPOSURE ; DRUG ; PREEXPOSURE ; METHAMPHETAMINE ; REINSTATEMENT ; INJECTION ; PSYCHOSIS ; SCHEDULE
英文摘要:

Rationale Cross-sensitization between cocaine and amphetamine has been demonstrated in different behavioral paradigms. There is a relative paucity of studies examining whether cross-sensitization occurs between amphetamine and cocaine when both are self-administered.

Objective The current study was designed to test whether animals sensitized to the reinforcing effects of cocaine would show cross-sensitization of the reinforcing effects of amphetamine, using a self-administration paradigm.

Materials and methods Male, Sprague-Dawley rats were trained to self-administer cocaine and given limited or high exposure to cocaine under a fixed ratio (FR) 1 procedure. After the initial exposure to cocaine, animals self-administered cocaine (1.5 mg/kg per injection) under a progressive ratio (PR) procedure. Subsequently, breakpoints on a PR schedule and rates of intake on an FR schedule maintained by different doses of amphetamine were assessed.

Results Animals with high initial exposure to cocaine (40 injections of 1.5 mg/kg per injection per day for 5 days) showed stable breakpoints throughout testing. Animals given limited initial cocaine exposure (20 injections of 0.75 mg/kg per injection for 1 day) produced a gradual increase in breakpoints maintained by cocaine over time (i.e., sensitization of the reinforcing effects of cocaine). When subsequently tested with amphetamine, the dose-effect curve was shifted upward in the limited-exposure group relative to the high-exposure group, suggesting cross-sensitization of the reinforcing effects of amphetamine.

Conclusions Sensitization of the reinforcing effects of cocaine resulted in cross-sensitization of the reinforcing effects of amphetamine. This phenomenon occurs even when both drugs are self-administered.

语种: 英语
WOS记录号: WOS:000251000600007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/121842
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Wake Forest Univ, Hlth Sci, Dept Physiol & Pharmacol, Winston Salem, NC 27157 USA
2.Peking Univ, Natl Institution Drug Dependence, Beijing 100083, Peoples R China
3.Univ Florida, Coll Med, Div Addiction Med, Dept Psychiat, Gainesville, FL 32610 USA

Recommended Citation:
Liu, Yu,Morgan, Drake,Roberts, David C. S.. Cross-sensitization of the reinforcing effects of cocaine and amphetamine in rats[J]. PSYCHOPHARMACOLOGY,2007,195(3):369-375.
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