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Elevated MicroRNA-31 Expression Regulates Colorectal Cancer Progression by Repressing Its Target Gene SATB2
Yang, Min-Hui1,2; Yu, Jiang3; Chen, Na2; Wang, Xiao-Yan1,2,4; Liu, Xiang-Yu; Wang, Shuang1,2; Ding, Yan-Qing1,2
刊名PLOS ONE
2013-12-30
DOI10.1371/journal.pone.0085353
8期:12
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者National Natural Science Foundation of China ; Major projects of National Natural Science Foundation of China ; State Key Program of National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; Key Program of National Natural Science Foundation of Guangdong, China ; National Natural Science Foundation of Guangdong, China ; National Natural Science Foundation of China ; Major projects of National Natural Science Foundation of China ; State Key Program of National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; Key Program of National Natural Science Foundation of Guangdong, China ; National Natural Science Foundation of Guangdong, China
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]SQUAMOUS-CELL CARCINOMA ; PROGNOSTIC-SIGNIFICANCE ; ONCOGENIC MICRORNA ; POOR-PROGNOSIS ; GASTRIC-CANCER ; MIR-31 ; METASTASIS ; SIGNATURE ; DIFFERENTIATION ; DIVISION
英文摘要

Several studies have brought about increasing evidence to support the hypothesis that miRNAs play a pivotal role in multiple processes of carcinogenesis, including cell growth, apoptosis, differentiation, and metastasis. In this study, we investigated the potential role of miR-31 in colorectal cancer (CRC) aggressiveness and its underlying mechanisms. We found that miR-31 increased in CRC cells originated from metastatic foci and human primary CRC tissues with lymph node metastases. Furthermore, the high-level expression of miR-31 was significantly associated with a more aggressive and poor prognostic phenotype of patients with CRC (p < 0.05). The stable over-expression of miR-31 in CRC cells was sufficient to promote cell proliferation, invasion, and migration in vitro. It facilitated tumor growth and metastasis in vivo too. Further studies showed that miR-31 can directly bind to the 3′ untranslated region (3′UTR) of SATB2 mRNA and subsequently repress both the mRNA and protein expressions of SATB2. Ectopic expression of SATB2 by transiently transfected with pCAG-SATB2 vector encoding the entire SATB2 coding sequence could reverse the effects of miR-31 on CRC tumorigenesis and progression. In addition, ectopic overexpression of miR-31 in CRC cells induced epithelial-mesenchymal transition (EMT). Our results illustrated that the up-regulation of miR-31 played an important role in CRC cell proliferation, invasion, and metastasis in vitro and in vivo through direct repressing SATB2, suggesting a potential application of miR-31 in prognosis prediction and therapeutic application in CRC.

语种英语
所属项目编号81000953 ; 81172242 ; 81071735 ; 81090422 ; U1201226 ; 2010CB529402 ; 2010B031500012 ; 10451051501004710
资助者National Natural Science Foundation of China ; Major projects of National Natural Science Foundation of China ; State Key Program of National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; Key Program of National Natural Science Foundation of Guangdong, China ; National Natural Science Foundation of Guangdong, China ; National Natural Science Foundation of China ; Major projects of National Natural Science Foundation of China ; State Key Program of National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; Key Program of National Natural Science Foundation of Guangdong, China ; National Natural Science Foundation of Guangdong, China
WOS记录号WOS:000329194700133
引用统计
被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/122214
专题北京大学医学部
作者单位1.Southern Med Univ, Nanfang Hosp, Dept Pathol, Guangzhou, Guangdong, Peoples R China
2.Southern Med Univ, Sch Basic Med Sci, Dept Pathol, Guangzhou, Guangdong, Peoples R China
3.Southern Med Univ, Nanfang Hosp, Dept Gen Surg, Guangzhou, Guangdong, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Yang, Min-Hui,Yu, Jiang,Chen, Na,et al. Elevated MicroRNA-31 Expression Regulates Colorectal Cancer Progression by Repressing Its Target Gene SATB2[J]. PLOS ONE,2013,8(12).
APA Yang, Min-Hui.,Yu, Jiang.,Chen, Na.,Wang, Xiao-Yan.,Liu, Xiang-Yu.,...&Ding, Yan-Qing.(2013).Elevated MicroRNA-31 Expression Regulates Colorectal Cancer Progression by Repressing Its Target Gene SATB2.PLOS ONE,8(12).
MLA Yang, Min-Hui,et al."Elevated MicroRNA-31 Expression Regulates Colorectal Cancer Progression by Repressing Its Target Gene SATB2".PLOS ONE 8.12(2013).
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