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IR@PKUHSC  > 北京大学口腔医学院  > 口腔颌面外科  > 期刊论文
学科主题: 口腔医学
题名:
Peptide-conjugated hyaluronic acid surface for the culture of human induced pluripotent stem cells under defined conditions
作者: Zhang, Xiaohong1,2; Zhou, Ping2; Zhao, Yinghui2; Wang, Mengke1; Wei, Shicheng1,2
关键词: Hyaluronic acid ; Peptide ; Human induced pluripotent stem cell ; Defined
刊名: CARBOHYDRATE POLYMERS
发表日期: 2016-01-20
DOI: 10.1016/j.carbpol.2015.09.081
卷: 136, 页:1061-1064
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Applied ; Chemistry, Organic ; Polymer Science
研究领域[WOS]: Chemistry ; Polymer Science
关键词[WOS]: HYDROGELS ; GROWTH
英文摘要:

Hyaluronic acid (HA) has been cross-linked to form hydrogel for potential applications in the self-renewal and differentiation of human pluripotent stem cells (hPSCs) for years. However, HA hydrogel with improved residence time and mechanical integrity that allows the survival of hPSCs under defined conditions is still much needed for clinical applications. In this study, HA was modified with methacrylate functional groups (MeHA) and cross-linked by photo-crosslinking method. After subsequent conjugation with adhesive peptide, these MeHA surfaces demonstrated performance in facilitating human induced pluripotent stem cells (hiPSCs) proliferation, and good pluripotency maintenance of hiPSCs under defined conditions. Moreover, MeHA films on glass-slides exhibited long residence time and mechanical stability throughout hiPSC culture. Our photo-crosslinkable MeHA possesses great value in accelerating the application of HA hydrogel in hiPSCs proliferation and differentiation with the conjugation of adhesive peptides. (c) 2015 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 81371697
项目资助者: National Natural Science Foundation of China ; Peking University&prime ; s 985 Grant
WOS记录号: WOS:000365972000126
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/122590
Appears in Collections:北京大学口腔医学院_口腔颌面外科_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
2.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100081, Peoples R China

Recommended Citation:
Zhang, Xiaohong,Zhou, Ping,Zhao, Yinghui,et al. Peptide-conjugated hyaluronic acid surface for the culture of human induced pluripotent stem cells under defined conditions[J]. CARBOHYDRATE POLYMERS,2016,136:1061-1064.
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