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学科主题口腔医学
Peptide-conjugated hyaluronic acid surface for the culture of human induced pluripotent stem cells under defined conditions
Zhang, Xiaohong1,2; Zhou, Ping2; Zhao, Yinghui2; Wang, Mengke1; Wei, Shicheng1,2
关键词Hyaluronic acid Peptide Human induced pluripotent stem cell Defined
刊名CARBOHYDRATE POLYMERS
2016-01-20
DOI10.1016/j.carbpol.2015.09.081
136页:1061-1064
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Applied ; Chemistry, Organic ; Polymer Science
研究领域[WOS]Chemistry ; Polymer Science
关键词[WOS]HYDROGELS ; GROWTH
英文摘要

Hyaluronic acid (HA) has been cross-linked to form hydrogel for potential applications in the self-renewal and differentiation of human pluripotent stem cells (hPSCs) for years. However, HA hydrogel with improved residence time and mechanical integrity that allows the survival of hPSCs under defined conditions is still much needed for clinical applications. In this study, HA was modified with methacrylate functional groups (MeHA) and cross-linked by photo-crosslinking method. After subsequent conjugation with adhesive peptide, these MeHA surfaces demonstrated performance in facilitating human induced pluripotent stem cells (hiPSCs) proliferation, and good pluripotency maintenance of hiPSCs under defined conditions. Moreover, MeHA films on glass-slides exhibited long residence time and mechanical stability throughout hiPSC culture. Our photo-crosslinkable MeHA possesses great value in accelerating the application of HA hydrogel in hiPSCs proliferation and differentiation with the conjugation of adhesive peptides. (c) 2015 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000365972000126
项目编号81371697
资助机构National Natural Science Foundation of China ; Peking University&prime ; s 985 Grant
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/122590
专题北京大学口腔医学院_口腔颌面外科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
2.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Xiaohong,Zhou, Ping,Zhao, Yinghui,et al. Peptide-conjugated hyaluronic acid surface for the culture of human induced pluripotent stem cells under defined conditions[J]. CARBOHYDRATE POLYMERS,2016,136:1061-1064.
APA Zhang, Xiaohong,Zhou, Ping,Zhao, Yinghui,Wang, Mengke,&Wei, Shicheng.(2016).Peptide-conjugated hyaluronic acid surface for the culture of human induced pluripotent stem cells under defined conditions.CARBOHYDRATE POLYMERS,136,1061-1064.
MLA Zhang, Xiaohong,et al."Peptide-conjugated hyaluronic acid surface for the culture of human induced pluripotent stem cells under defined conditions".CARBOHYDRATE POLYMERS 136(2016):1061-1064.
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