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Agmatine blocks acquisition and re-acquisition of intravenous morphine self-administration in rats
Su, Rui-Bin1; Wang, Wei-Ping2; Lu, Xin-Qiang1; Wu, Ning1; Liu, Zhi-min2; Li, Jin1
关键词Morphine Agmatine Drug self-administration
刊名PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
2009-06-01
DOI10.1016/j.pbb.2009.03.009
92期:4页:676-682
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]NITRIC-OXIDE SYNTHASE ; SUBSTANCE DEPENDENCE ; ETHANOL WITHDRAWAL ; ADDICTION ; COCAINE ; INHIBITION ; TOLERANCE ; SEEKING ; STRESS ; HEROIN
英文摘要

Our previous studies showed that agmatine inhibits morphine-induced conditioned place preference, locomotor sensitization and drug discrimination in rats. in the present study, we investigated the effects of agmatine on intravenous morphine self-administration in rats. At a dose of 80 mg/kg/infusion, agmatine did not substitute for intravenous morphine (0.5 mg/kg/infusion) self-administration, suggesting that agmatine itself has no reinforcing effect. However, pretreatment with agmatine (40 or 80 mg/kg, i.g.) significantly inhibited the acquisition of intravenous morphine self-administration as assessed by the nose-poke response and morphine intake. The mean number of days required to meet the acquisition criteria for intravenous morphine self-administration was significantly prolonged. After acquisition of intravenous morphine self-administration, chronic administration of agmatine (40 or 80 mg/kg x 30 days, bid, i.g.) during the extinction period significantly prevented the re-acquisition of intravenous morphine self-administration. The ability of agmatine to inhibit the acquisition and re-acquisition of intravenous morphine self-administration suggests a possible use of agmatine in the treatment of opioid dependence. (c) 2009 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000266538800018
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/122607
专题中国药物依赖性研究所
作者单位1.Beijing Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China
2.Peking Univ, Natl Inst Drug Dependence China, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Su, Rui-Bin,Wang, Wei-Ping,Lu, Xin-Qiang,et al. Agmatine blocks acquisition and re-acquisition of intravenous morphine self-administration in rats[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2009,92(4):676-682.
APA Su, Rui-Bin,Wang, Wei-Ping,Lu, Xin-Qiang,Wu, Ning,Liu, Zhi-min,&Li, Jin.(2009).Agmatine blocks acquisition and re-acquisition of intravenous morphine self-administration in rats.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,92(4),676-682.
MLA Su, Rui-Bin,et al."Agmatine blocks acquisition and re-acquisition of intravenous morphine self-administration in rats".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 92.4(2009):676-682.
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