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学科主题: 药物依赖
题名:
Agmatine blocks acquisition and re-acquisition of intravenous morphine self-administration in rats
作者: Su, Rui-Bin1; Wang, Wei-Ping2; Lu, Xin-Qiang1; Wu, Ning1; Liu, Zhi-min2; Li, Jin1
关键词: Morphine ; Agmatine ; Drug self-administration
刊名: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
发表日期: 2009-06-01
DOI: 10.1016/j.pbb.2009.03.009
卷: 92, 期:4, 页:676-682
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]: NITRIC-OXIDE SYNTHASE ; SUBSTANCE DEPENDENCE ; ETHANOL WITHDRAWAL ; ADDICTION ; COCAINE ; INHIBITION ; TOLERANCE ; SEEKING ; STRESS ; HEROIN
英文摘要:

Our previous studies showed that agmatine inhibits morphine-induced conditioned place preference, locomotor sensitization and drug discrimination in rats. in the present study, we investigated the effects of agmatine on intravenous morphine self-administration in rats. At a dose of 80 mg/kg/infusion, agmatine did not substitute for intravenous morphine (0.5 mg/kg/infusion) self-administration, suggesting that agmatine itself has no reinforcing effect. However, pretreatment with agmatine (40 or 80 mg/kg, i.g.) significantly inhibited the acquisition of intravenous morphine self-administration as assessed by the nose-poke response and morphine intake. The mean number of days required to meet the acquisition criteria for intravenous morphine self-administration was significantly prolonged. After acquisition of intravenous morphine self-administration, chronic administration of agmatine (40 or 80 mg/kg x 30 days, bid, i.g.) during the extinction period significantly prevented the re-acquisition of intravenous morphine self-administration. The ability of agmatine to inhibit the acquisition and re-acquisition of intravenous morphine self-administration suggests a possible use of agmatine in the treatment of opioid dependence. (c) 2009 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2003CB515400 ; 2009CB522000 ; 2007BAI071302
项目资助者: National Basic Research Program of China ; National Key Technology R&amp ; D Program of China
WOS记录号: WOS:000266538800018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/122607
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Beijing Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China
2.Peking Univ, Natl Inst Drug Dependence China, Beijing 100083, Peoples R China

Recommended Citation:
Su, Rui-Bin,Wang, Wei-Ping,Lu, Xin-Qiang,et al. Agmatine blocks acquisition and re-acquisition of intravenous morphine self-administration in rats[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2009,92(4):676-682.
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