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学科主题: 药物依赖
题名:
Agmatine inhibits morphine-induced drug discrimination in rats
作者: Su, Rui-Bin1; Ren, Yan-Hua2; Liu, Yang3; Ding, Ting3; Lu, Xin-Qiang1; Wu, Ning1; Liu, Zhi-Min2; Li, Jin1
关键词: morphine ; agmatine ; drug discrimination
刊名: EUROPEAN JOURNAL OF PHARMACOLOGY
发表日期: 2008-09-28
DOI: 10.1016/j.ejphar.2008.07.012
卷: 593, 期:1-3, 页:62-67
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: ABSTINENCE SYNDROME ; TREATED RATS ; DEPENDENCE ; ADDICTION ; TOLERANCE ; RECEPTOR ; MICE ; ACTIVATION ; WITHDRAWAL ; COCAINE
英文摘要:

Our previous studies have shown that agmatine inhibited morphine-induced conditioned place preference and locomotor sensitization in rats. In the present study, we further investigated the effects of agmatine on the discriminative stimulating effects produced by morphine in rats. Agmatine, at the dose range of 1080 mg/kg (i.g.), neither induced drug discrimination, nor substituted for morphine stimulus in rats that were previously treated with morphine, suggesting that agmatine itself has no psychomotor-stimulating potential. However, pretreatment with agmatine (40, 80 mg/kg, i.g.) significantly inhibited the acquisition, but not expression, of morphine-induced drug discrimination as assessed by the correct nose-poke response. Further, chronic administration of agmatine (40, 80 mg/kg/day x 12 days, i.g.. 25 min prior to morphine) also significantly accelerated the extinction of the discrimination induced by morphine. These data suggest that agmatine inhibits the acquisition and accelerates the extinction of morphine-induced discrimination, supporting possible use of agmatine in the treatment of opioid dependence. (C) 2008 Published by Elsevier B.V.

语种: 英语
所属项目编号: 2003CB515400 ; 2007BAI071302
项目资助者: National Basic Research Program of China ; National Key Technology R&amp ; D Program of China
WOS记录号: WOS:000259508100009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/122977
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Beijing Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China
2.Peking Univ, Natl Inst Drug Dependence China, Beijing 100083, Peoples R China
3.Peking Univ, Dept Clin Med, Hlth Sci Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Su, Rui-Bin,Ren, Yan-Hua,Liu, Yang,et al. Agmatine inhibits morphine-induced drug discrimination in rats[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2008,593(1-3):62-67.
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