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Somatostatin receptor subtype 2-mediated scintigraphy and localization using (99m)Tc-HYNIC-Tyr(3)-octreotide in human hepatocellular carcinoma-bearing nude mice
Li, Yong1; Si, Jian-Ming1; Zhang, Jun1; Du, Jin2; Wang, Fan2; Jia, Bing2
关键词Hepatocellular carcinoma (99m)Tc-HYNIC-Tyr(3)-octreotide Somatostatin receptor 2
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2005-07-07
11期:25页:3953-3957
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
英文摘要

AIM: To investigate the uptake of (99m)Tc-HYNIC-Tyr(3)-octreotide ((99m)Tc-HYNIC-TOC) in human hepatocellular carcinoma (HCC), which can provide the localizable diagnosis in hepatic carcinoma.

METHODS: The expression of somatostatin receptor 2 (SSTR2) messenger RNA (mRNA) in human HCC cell line HepG(2) was examined by reverse transcriptase-polymerase chain reaction (RT-PCR). Uptake of (99m)Tc-HYNIC-TOC was evaluated in the human HCC implanted into BALB/c nude mice. ANMIS2000 nuclear medicine analysis system was used to calculate the ratio of (99m)Tc uptake between tumor tissue and vital organs.

RESULTS: We demonstrated the expression of SSTR2 mRNA in human HCC cell line HepG(2) by RT-PCR. The size of the RT-PCR products was 364 bp detected by sequence analysis of the human SSTR2 mRNA. Scintigraphy proved that (99m)Tc-HYNIC-TOC was uptaken in the tumor tissue, liver and kidney of the tumor-bearing mice.

CONCLUSION: Based on expression of the SSTR2 mRNA in human HCC, (99m)Tc-HYNIC-TOC can markedly bind with and be uptaken by human HCC tissues as compared with normal liver tissue. The significant retention of radionuclide in kidney and bladder is probably related to non-specific peptide uptake in the tubulus cells of kidney and possibly due to excretion by kidney. Our results show that localizable diagnosis and targeting radiotherapy with radionuclide-labeled somatostatin analog for HCC are of great value to be further studied.(C) 2005 The WJG Press and Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000208099200028
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/123640
专题北京大学医药卫生分析中心_同位素实验室
北京大学基础医学院
作者单位1.Zhejiang Univ, Sir Run Run Shaw Hosp, Gastrointestinal Lab, Inst Clin Med, Hangzhou 310016, Zhejiang Provin, Peoples R China
2.Beijing Univ, Med Isotope Res Ctr, Beijing 100083, Peoples R China
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GB/T 7714
Li, Yong,Si, Jian-Ming,Zhang, Jun,et al. Somatostatin receptor subtype 2-mediated scintigraphy and localization using (99m)Tc-HYNIC-Tyr(3)-octreotide in human hepatocellular carcinoma-bearing nude mice[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2005,11(25):3953-3957.
APA Li, Yong,Si, Jian-Ming,Zhang, Jun,Du, Jin,Wang, Fan,&Jia, Bing.(2005).Somatostatin receptor subtype 2-mediated scintigraphy and localization using (99m)Tc-HYNIC-Tyr(3)-octreotide in human hepatocellular carcinoma-bearing nude mice.WORLD JOURNAL OF GASTROENTEROLOGY,11(25),3953-3957.
MLA Li, Yong,et al."Somatostatin receptor subtype 2-mediated scintigraphy and localization using (99m)Tc-HYNIC-Tyr(3)-octreotide in human hepatocellular carcinoma-bearing nude mice".WORLD JOURNAL OF GASTROENTEROLOGY 11.25(2005):3953-3957.
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