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学科主题: 临床医学
题名:
Predictors of exacerbation frequency in chronic obstructive pulmonary disease
作者: Yang, Hui1,2; Xiang, Pingchao2; Zhang, Erming2; Guo, Wei′ An2; Shi, Yanwei2; Zhang, Shuo2; Tong, Zhaohui1
关键词: Chronic obstructive pulmonary disease ; Exacerbation ; Forced expiratory volume ; Comorbidity ; Positive pressure ventilation
刊名: EUROPEAN JOURNAL OF MEDICAL RESEARCH
发表日期: 2014-04-08
DOI: 10.1186/2047-783X-19-18
卷: 19
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: QUALITY-OF-LIFE ; LUNG-FUNCTION ; COPD ; DECLINE ; FLUTICASONE ; SALMETEROL ; TRIAL
英文摘要:

Background: Exacerbations of chronic obstructive pulmonary disease (COPD) are sporadic, acute worsening of symptoms. Identifying predictors of exacerbation frequency may facilitate medical interventions that reduce exacerbation frequency and severity. The objective of this study was to determine predictors of exacerbation frequency and mortality.

Methods: A total of 227 COPD patients were enrolled in a prospective clinical study between January 2000 and December 2011. Reported exacerbations were recorded for the year preceding enrollment and annually thereafter, and patients were grouped by median annual exacerbation frequency into those experiencing infrequent exacerbations (less than one exacerbation annually) and frequent exacerbations (one or more exacerbation annually). Patients experiencing frequent exacerbations were further divided into those experiencing moderately frequent exacerbations (fewer than two exacerbations per year) and severely frequent exacerbations (two or more exacerbations per year). The rate of clinical relapse and survival was recorded over a 10-year period. The mean of follow-up time was 5.15 years per patient.

Results: For patients experiencing infrequent, moderately frequent, and severely frequent exacerbations, median exacerbations in the year preceding enrollment were 0.0, 0.5, 1.0, respectively, and more frequent exacerbations correlated with lower baseline forced expiratory volume in one second (FEV1) (0.81 L, 0.75 L, and 0.66 L, respectively), higher comorbidity (70.7%, 75.0%, and 89.4%, respectively), and greater NPPV use during hospitalization (16.4%, 35.9% and 51.1%, respectively). FEV1 declined and mortality increased with increasing exacerbation frequency.

Conclusions: Exacerbation frequency can be used to generate discreet patient subpopulations, supporting the hypothesis that multiple COPD phenotypes exist and can be used in patient risk stratification.

语种: 英语
所属项目编号: 2011-2-06
项目资助者: Beijing High-grade Talents Health Technology Fund
WOS记录号: WOS:000335179300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/123728
Appears in Collections:北京大学首钢医院_重症监护科_期刊论文

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作者单位: 1.Capital Med Univ, Beijing Chao Yang Hosp Beijing, Beijing Inst Resp Med, Dept Resp & Crit Care Med, Beijing 100020, Peoples R China
2.Peking Univ, Shou Gang Hosp, Dept Resp & Crit Care Med, Beijing 100041, Peoples R China

Recommended Citation:
Yang, Hui,Xiang, Pingchao,Zhang, Erming,et al. Predictors of exacerbation frequency in chronic obstructive pulmonary disease[J]. EUROPEAN JOURNAL OF MEDICAL RESEARCH,2014,19.
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