IR@PKUHSC  > 北京大学第九临床医学院
学科主题神经病学
血清脂蛋白(a)水平与脑梗死患者神经功能缺损严重程度的相关性
鲍金
2016-05-17
导师贺茂林
专业神经病学
授予单位北京大学
授予地点北京大学第九临床医学院
学位硕士
关键词脑梗死 脂蛋白(a) NIHSS评分
其他题名The Relationship Between Serum Levels of Lipoprotein(a)and the Severity of Cerebral Infarction
分类号R743.33
摘要

目的:探讨急性脑梗死患者血清脂蛋白(a)[Lp(a)]水平,及其同神经功能缺损严重程度的关系。

方法:选择自2014年1月至2016年1月入住北京世纪坛医院神经内科病区符合入选标准的88例急性非心源性脑梗死患者,及同期门诊复查的非心源性脑梗死恢复期患者76例,同期来院的69例健康体检者为研究对象。神经功能缺损严重程度采用美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分来评价。分析急性脑梗死患者与恢复期脑梗死患者、健康体检者血清Lp(a)水平的差异,及其与NIHSS评分之间的关系。

结果:急性脑梗死组患者血清Lp(a)中位水平为0.15g/L(IQR 0.07-0.41g/L),高于正常对照组[Lp(a)中位水平0.10g/L,IQR 0.04-0.16g/L],及脑梗死恢复期患者[Lp(a)中位水平0.135g/L,IQR 0.09-0.30g/L],差异有统计学意义(分别为P<0.01,P=0.041)。血清Lp(a)水平与脑梗死的发生风险呈正相关(OR:6.931;95%CI:2.483~19.345;P<0.001),分析血清Lp(a)水平同NIHSS评分之间呈正相关,相关系数r=0.373(P<0.001),不同NIHSS评分亚组组间差异有统计学意义(P<0.05)。

结论:急性脑梗死患者血清Lp(a)水平升高,其水平越高提示神经功能缺损程度越严重。

英文摘要

Objective: To explore the serum lipoprotein(a) [Lp(a)] levels of acute cerebral infarction and its relation to the severity of ischemic stroke.

Methods: We recruited 88 acute cerebral infarction patients, 76 patients with a history of ischemic stroke more than 3 months, and 69 healthy controls. All the cerebral infarction patients belong to the noncardioembolic subtype according to TOAST criteria. The severity of stroke was assessed by using the National Institutes of Health Stroke Scale. We analysed the different serum Lp(a) levels between acute cerebral infarction patients and two control groups. Further more, we studied the relationship between serum Lp(a) levels and the severity of ischemic stroke.

Results: The median serum Lp(a) level of acute cerebral infarction patients is 0.15g/L(IQR 0.07-0.41g/L), which is higher than the two control groups(0.10g/L,IQR 0.04-0.16g/L; 0.135g/L,IQR 0.09-0.30g/L, respectively), and the difference were significant(P<0.01; P=0.041, respectively). Serum Lp(a) levels were positively correlated with the risk of ischemic stroke(OR:6.931;95%CI:2.483~19.345;P<0.001). The serum levels of Lp(a) were also associated with the severity of ischemic stroke( r=0.373, P<0.001). The statistical difference was significant between different subtypes according to NIHSS(P<0.05).

Conclusions: Lp(a) levels are high in patients with acute cerebral infarction and are associated with increased severity of ischemic stroke.

语种中文
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文献类型学位论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/124802
Collection北京大学第九临床医学院
作者单位北京大学第九临床医学院
Recommended Citation
GB/T 7714
鲍金. 血清脂蛋白(a)水平与脑梗死患者神经功能缺损严重程度的相关性[D]. 北京大学第九临床医学院. 北京大学,2016.
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