IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科
Exome-wide association study of plasma lipids in > 300,000 individuals
Liu, Dajiang J.1; Peloso, Gina M.2,3; Yu, Haojie4; Butterworth, Adam S.6; Wang, Xiao7; Mahajan, Anubha8; Saleheen, Danish9,10; Emdin, Connor3,11; Alam, Dewan12; Alves, Alexessander Couto13; Amouyel, Philippe14; Di Angelantonio, Emanuele6; Arveiler, Dominique15; Assimes, Themistocles L.16,17; Auer, Paul L.18; Baber, Usman19; Ballantyne, Christie M.20; Bang, Lia E.21; Benn, Marianne22,23; Bis, Joshua C.24; Boehnke, Michael25; Boerwinkle, Eric26,27; Bork-Jensen, Jette28; Bottinger, Erwin P.29; Brandslund, Ivan30,31; Brown, Morris32; Busonero, Fabio; Caulfield, Mark J.32,34,35; Chambers, John C.36,37,38; Chasman, Daniel I.39,40; Chen, Y. Eugene41; Chen, Yii-Der Ida42,43; Chowdhury, Rajiv; Christensen, Cramer44; Chu, Audrey Y.39,45; Connell, John M.46; Cucca, Francesco47; Cupples, L. Adrienne2,45; Damrauer, Scott M.48,49; Davies, Gail50,51; Deary, Ian J.50,51; Dedoussis, George52; Denny, Joshua C.53,54; Dominiczak, Anna55; Dube, Marie-Pierre56,57,58; Ebeling, Tapani59,60; Eiriksdottir, Gudny61; Esko, Tonu3,62; Farmaki, Aliki-Eleni52; Feitosa, Mary F.63; Ferrario, Marco64; Ferrieres, Jean65; Ford, Ian66; Fornage, Myriam67; Franks, Paul W.68,69,70; Frayling, Timothy M.71; Frikke-Schmidt, Ruth22,23; Fritsche, Lars G.25; Frossard, Philippe10; Fuster, Valentin19,72; Ganesh, Santhi K.41,73; Gao, Wei74; Garcia, Melissa E.75; Gieger, Christian76,77,78; Giulianini, Franco39; Goodarzi, Mark O.79,80,81; Grallert, Harald76,77,78; Grarup, Niels28; Groop, Leif82; Grove, Megan L.26; Gudnason, Vilmundur61,83; Hansen, Torben28,84; Harris, Tamara B.85; Hayward, Caroline86; Hirschhorn, Joel N.3,87,88; Holmen, Oddgeir L.89,90; Huffman, Jennifer86; Huo, Yong91; Hveem, Kristian92; Jabeen, Sehrish10; Jackson, Anne U.25; Jakobsdottir, Johanna61,93; Jarvelin, Marjo-Riitta13; Jensen, Gorm B.94; Jorgensen, Marit E.95,96; Jukema, J. Wouter97,98; Justesen, Johanne M.28; Kamstrup, Pia R.99,100; Kanoni, Stavroula101; Karpe, Fredrik102,103; Kee, Frank104; Khera, Amit V.3,11; Klarin, Derek3,11,105; Koistinen, Heikki A.107,108,109,110; Kooner, Jaspal S.37,38,111; Kooperberg, Charles112; Kuulasmaa, Kari; Kuusisto, Johanna113,114; Laakso, Markku113,114; Lakka, Timo115,116,117; Langenberg, Claudia118; Langsted, Anne99,100,119; Launer, Lenore J.85; Lauritzen, Torsten120; Liewald, David C. M.50,51; Lin, Li An67; Linneberg, Allan121,122,123; Loos, Ruth J. F.29,124; Lu, Yingchang29; Lu, Xiangfeng41,125,126; Magi, Reedik62; Malarstig, Anders127,128; Manichaikul, Ani129; Manning, Alisa K.3,11,130; Mantyselka, Pekka131,132; Marouli, Eirini101; Masca, Nicholas G. D.133,134; Maschio, Andrea; Meigs, James B.3,130,135; Melander, Olle136; Metspalu, Andres62; Morris, Andrew P.8,137; Morrison, Alanna C.26; Mulas, Antonella; Mueller-Nurasyid, Martina78,138,139; Munroe, Patricia B.32,35; Neville, Matt J.102; Nielsen, Jonas B.41; Nielsen, Sune F.99,100,119; Nordestgaard, Borge G.99,100,119; Ordovas, Jose M.140,141,142; Mehran, Roxana19; O′ Donnell, Christoper J.105,143; Orho-Melander, Marju136; Molony, Cliona M.144; Muntendam, Pieter145; Padmanabhan, Sandosh55; Palmer, Colin N. A.46; Pasko, Dorota71; Patel, Aniruddh P.3,11,143,146; Pedersen, Oluf28; Perola, Markus147; Peters, Annette76,78,139; Pisinger, Charlotta123; Pistis, Giorgio33; Polasek, Ozren148,149; Poulter, Neil150; Psaty, Bruce M.24,151,152,153; Rader, Daniel J.154,155,156; Rasheed, Asif10; Rauramaa, Rainer116,117; Reilly, Dermot F.144; Reiner, Alex P.112,157; Renstrom, Frida68,158; Rich, Stephen S.129; Ridker, Paul M.39; Rioux, John D.56; Robertson, Neil R.8,102; Roden, Dan M.53,54; Rotter, Jerome I.42,43; Rudan, Igor149; Salomaa, Veikko; Samani, Nilesh J.133,134; Sanna, Serena33; Sattar, Naveed55,102; Schmidt, Ellen M.159; Scott, Robert A.118; Sever, Peter150; Sevilla, Raquel S.160; Shaffer, Christian M.54; Sim, Xueling25,161; Sivapalaratnam, Suthesh162; Small, Kerrin S.163; Smith, Albert V.61,83; Smith, Blair H.164,165; Somayajula, Sangeetha166; Southam, Lorraine8,167; Spector, Timothy D.163; Speliotes, Elizabeth K.159,168; Starr, John M.50,169; Stirrups, Kathleen E.101,170; Stitziel, Nathan171,172,173; Strauch, Konstantin174,175; Stringham, Heather M.25; Surendran, Praveen; Tada, Hayato176; Tall, Alan R.177; Tang, Hua178; Tardif, Jean-Claude56,58; Taylor, Kent D.42,43; Trompet, Stella97,179; Tsao, Philip S.16,17; Tuomilehto, Jaakko180,181,182,183; Tybjaerg-Hansen, Anne22,23; van Zuydam, Natalie R.8,46; Varbo, Anette99,100,119; Varga, Tibor V.68; Virtamo, Jarmo106; Waldenberger, Melanie77,78,139; Wang, Nan177; Wareham, Nick J.118; Warren, Helen R.32,35; Weeke, Peter E.54,184; Weinstock, Joshua25; Wessel, Jennifer185,186; Wilson, James G.187; Wilson, Peter W. F.188,189; Xu, Ming190; Yaghootkar, Hanieh71; Young, Robin; Zeggini, Eleftheria167; Zhang, He41; Zheng, Neil S.191; Zhang, Weihua36; Zhang, Yan91; Zhou, Wei159; Zhou, Yanhua2; Zoledziewska, Magdalena33; Howson, Joanna M. M.; Danesh, John5,6,167; McCarthy, Mark I.8,102,103; Cowan, Chad A.4,192; Abecasis, Goncalo25; Deloukas, Panos101,193; Musunuru, Kiran7; Willer, Cristen J.41,73,159; Kathiresan, Sekar3,11,143,146; Charge Diabet Working Grp; EPIC-InterAct Consortium; EPIC-CVD Consortium; GOLD Consortium; VA Million Veteran Program; Willer, Cristen J.(41,73,159); Kathiresan, Sekar(3,11,143,146)
Source PublicationNATURE GENETICS
2017-12-01
Volume49Issue:12Pages:1758-+
Indexed BySCI
Abstract

We screened variants on an exome-focused genotyping array in >300,000 participants (replication in >280,000 participants) and identified 444 independent variants in 250 loci significantly associated with total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-C), low-densitylipoprotein cholesterol (LDL-C), and/or triglycerides (TG). At two loci (JAK2 and A1CF), experimental analysis in mice showed lipid changes consistent with the human data. We also found that: (i) beta-thalassemia trait carriers displayed lower TC and were protected from coronary artery disease (CAD); (ii) excluding the CETP locus, there was not a predictable relationship between plasma HDL-C and risk for age-related macular degeneration; (iii) only some mechanisms of lowering LDL-C appeared to increase risk for type 2 diabetes (T2D); and (iv) TG-lowering alleles involved in hepatic production of TG-rich lipoproteins (TM6SF2 and PNPLA3) tracked with higher liver fat, higher risk for T2D, and lower risk for CAD, whereas TG-lowering alleles involved in peripheral lipolysis (LPL and ANGPTL4) had no effect on liver fat but decreased risks for both T2D and CAD.

Subject Area临床医学
SubtypeLetter
DOI10.1038/ng.3977
URL查看原文
WOS HeadingsScience & Technology
Language英语
Funding OrganizationNational Human Genome Research Institute of the National Institute of Health ; National Institute of Drug Abuse of the National Institute of Health ; National Heart, Lung, and Blood Institute of the National Institutes of Health ; Stanley J. Sarnoff Cardiovascular Research Foundation ; Japanese Circulation Society ; National Institute for Health Research (NIHR) Exeter Clinical Research Facility ; ERC ; NIH ; University of Michigan Biological Sciences Scholars Program ; University of Michigan Department of Internal Medicine ; ERC Advanced Principal Investigator award ; Wellcome Trust Senior Fellow in Basic Biomedical Science ; NHLBI R21 from the NIH ; Medical Research Council, UK ; British Heart Foundation ; European Research Council Senior Investigator ; National Institute for Health Research (NIHR) Senior Investigator ; Massachusetts General Hospital ; Donovan Family Foundation
WOS Research AreaGenetics & Heredity ; Genetics & Heredity
WOS SubjectGenetics & Heredity
WOS KeywordAPOBEC-1 COMPLEMENTATION FACTOR ; CODING-SEQUENCE VARIANTS ; TYROSINE KINASE JAK2 ; B MESSENGER-RNA ; MACULAR DEGENERATION ; GENETIC ARCHITECTURE ; LOW-FREQUENCY ; MYELOPROLIFERATIVE DISORDERS ; CARDIOVASCULAR-DISEASE ; CLONAL HEMATOPOIESIS
WOS IDWOS:000416480600016
Citation statistics
Cited Times:203[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.bjmu.edu.cn/handle/400002259/135060
Collection北京大学第一临床医学院_心血管内科
北京大学第一临床医学院_急诊科
北京大学第三临床医学院_心血管内科
北京大学口腔医学院_儿童口腔科
Corresponding AuthorWiller, Cristen J.(41,73,159); Kathiresan, Sekar(3,11,143,146)
Affiliation1.Kuopio Res Inst Exercise Med, Kuopio, Finland;
2.Univ Denmark, Fac Hlth & Med Sci, Copenhagen, Denmark;
3.Rigshosp, Dept Clin Expt Res, Glostrup, Denmark;
4.IMDEA Alimentac, Madrid, Spain;
5.Harvard Med Sch, Dept Med, Boston, MA 02115 USA;
6.Merck Sharp & Dohme Corp, Genet, Kenilworth, NJ USA;
7.G3 Pharmaceut, Lexington, MA USA;
8.Univ Helsinki, Inst Mol Med FIMM, Helsinki, Finland;
9.Univ Split, Fac Med, Split, Croatia;
10.Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA;
11.Kaiser Permanente, Washington Hlth Res Inst, Seattle, WA USA;
12.Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England;
13.Umea Univ, Dept Biobank Res, Umea, Sweden;
14.Ctr Noncommunicable Dis, Karachi, Pakistan;
15.Merck Sharp & Dohme Corp, Imaging, Kenilworth, NJ USA;
16.Merck Sharp & Dohme Corp, Sci Informat, Kenilworth, NJ USA;
17.Wellcome Trust Sanger Inst, Genome Campus, Hinxton, England;
18.ICDDR B, Dhaka, Bangladesh;
19.Univ Cambridge, Dept Haematol, Cambridge, England;
20.Imperial Coll London, London, England;
21.VA Palo Alto Hlth Care Syst, Palo Alto, CA USA;
22.Stanford Univ, Sch Med, Dept Med, Stanford, CA USA;
23.Baylor Coll Med, Dept Med, Houston, TX 77030 USA;
24.Columbia Univ, Div Mol Med, Dept Med, New York, NY USA;
25.Stanford Univ, Sch Med, Dept Genet, Stanford, CA USA;
26.Dasman Diabet Inst, Dasman, Kuwait;
27.Danube Univ Krems, Ctr Vasc Prevent, Krems, Austria;
28.Penn State Coll Med, Inst Personalized Med, Dept Publ Hlth Sci, Hershey, PA USA;
29.Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA;
30.Harvard Univ, Harvard Stem Cell Inst, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA;
31.Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge, England;
32.Univ Cambridge, Natl Inst Hlth Res Blood & Transplant Res Unit NI, Donor Hlth & Genom, Cambridge, England;
33.Univ Penn, Perelman Sch Med, Cardiovasc Inst, Philadelphia, PA 19104 USA;
34.Univ Penn, Dept Biostat & Epidemiol, Perelman Sch Med, Philadelphia, PA 19104 USA;
35.Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA 02114 USA;
36.Univ Lille, INSERM, CHU Lille, Inst Pasteur Lille,Risk Factors & Mol Determinant, Lille, France;
37.Univ Strasbourg, Dept Epidemiol & Publ Hlth, EA 3430, Strasbourg, France;
38.Univ Wisconsin Milwaukee, Zilber Sch Publ Hlth, Milwaukee, WI USA;
39.Mt Sinai Med Ctr, Icahn Sch Med Mt Sinai, Cardiovasc Inst, New York, NY 10029 USA;
40.Copenhagen Univ Hosp, Dept Cardiol, Rigshosp, Copenhagen, Denmark;
41.Rigshosp, Dept Clin Biochem, Copenhagen, Denmark;
42.Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark;
43.Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA;
44.Univ Michigan, Sch Publ Hlth, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA;
45.Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Ctr Human Genet, Houston, TX 77030 USA;
46.Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA;
47.Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark;
48.Ichan Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY USA;
49.Lillebaelt Hosp, Dept Clin Biochem, Vejle, Denmark;
50.Univ Southern Denmark, Inst Reg Hlth Res, Odense, Denmark;
51.Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, Clin Pharmacol, London, England;
52.CNR, Ist Ric Genet & Biomed, Cagliari, Italy;
53.Ealing Hosp NHS Trust, Dept Cardiol, Southall, Middx, England;
54.Imperial Coll Healthcare NHS Trust, London, England;
55.Harvard Med Sch, Dept Med, Boston, MA USA;
56.Queen Mary Univ London, William Harvey Res Inst, Barts Heart Ctr, London, England;
57.Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Unit, London, England;
58.Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England;
59.Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA;
60.Univ Michigan, Div Cardiovasc Med, Dept Internal Med, Ann Arbor, MI 48109 USA;
61.LABioMed Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Los Angeles, CA USA;
62.LABioMed Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Med, Los Angeles, CA USA;
63.NHLBI Framingham Heart Study, Framingham, MA USA;
64.Univ Dundee, Med Res Inst, Ninewells Hosp & Med Sch, Dundee, Scotland;
65.Univ Penn, Dept Surg, Perelman Sch Med, Philadelphia, PA 19104 USA;
66.Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland;
67.Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland;
68.Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece;
69.Vanderbilt Univ, Med Ctr, Dept Biomed Informat, 221 Kirkland Hall, Nashville, TN 37235 USA;
70.Univ Glasgow, Coll Med Vet & Life Sci, Inst Cardiovasc & Med Sci, British Heart Fdn Glasgow Cardiovasc Res Ctr, Glasgow, Lanark, Scotland;
71.Montreal Heart Inst, Montreal, PQ, Canada;
72.Univ Montreal, Beaulieu Saucier Pharmacogen Ctr, Montreal, PQ, Canada;
73.Univ Montreal, Montreal, PQ, Canada;
74.Oulu Univ Hosp, Dept Med, Oulu, Finland;
75.Univ Oulu, Oulu, Finland;
76.Iceland Heart Assoc, Kopavogur, Iceland;
77.Univ Tartu, Estonian Genome Ctr, Tartu, Estonia;
78.Washington Univ, Sch Med, Dept Genet, Div Stat Gen, St Louis, MO 63110 USA;
79.Univ Insubria, Dept Med & Surg, Res Ctr Epidemiol & Prevent Med EPIMED, Varese, Italy;
80.CHU Toulouse, Dept Epidemiol, INSERM, UMR 1027,Toulouse Univ, Toulouse, France;
81.Univ Glasgow, Robertson Ctr Biostat, Glasgow, Lanark, Scotland;
82.Univ Texas Hlth Sci Ctr Houston, Inst Mol Med, Houston, TX 77030 USA;
83.Lund Univ, Genet & Mol Epidemiol Unit, Dept Clin Sci, Malmo, Sweden;
84.Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden;
85.Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA;
86.German Ctr Diabet Res DZD & V, Neuherberg, Germany;
87.Univ Iceland, Fac Med, Reykjavik, Iceland;
88.Univ Southern Denmark, Fac Hlth Sci, Odense, Denmark;
89.Univ Exeter, Genet Complex Traits, Univ Exeter Med Sch, Exeter, Devon, England;
90.Ctr Nacl Invest Cardiovasc Carlos III CNIC, Madrid, Spain;
91.Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA;
92.Peking Univ, Hosp 3, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Minist Hlth,Dept Cardiol, Beijing, Peoples R China;
93.NHLBI, Bldg 10, Bethesda, MD 20892 USA;
94.Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Neuherberg, Germany;
95.Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, Neuherberg, Germany;
96.Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA 90048 USA;
97.Cedars Sinai Med Ctr, Dept Biomed Sci, Los Angeles, CA 90048 USA;
98.Cedars Sinai Med Ctr, Div Endocrinol Diabet & Metab, Los Angeles, CA 90048 USA;
99.Lund Univ, Clin Res Ctr, Dept Clin Sci Diabet & Endocrinol, Malmo, Sweden;
100.Natl Inst Aging, Lab Epidemiol & Populat Sci, Bethesda, MD USA;
101.Univ Edinburgh, Inst Genet & Mol Med, Med Res Council Human Genet Unit, Edinburgh, Midlothian, Scotland;
102.Boston Childrens Hosp, Div Endocrinol, Boston, MA USA;
103.Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA USA;
104.Norwegian Univ Sci & Technol, HUNT Res Ctr, Dept Publ Hlth & Gen Practice, Levanger, Norway;
105.Univ Trondheim Hosp, St Olavs Hosp, Trondheim, Norway;
106.Peking Univ, Hosp 1, Dept Cardiol, Beijing, Peoples R China;
107.Norwegian Univ Sci & Technol NTNU, Fac Med & Hlth Sci, Dept Publ Hlth & Nursing, KG Jebsen Ctr Genet Epidemiol, Trondheim, Norway;
108.Univ Iceland, Dept Hlth Sci, Reykjavik, Iceland;
109.Frederiksberg Univ Hosp, Copenhagen City Heart Study, Copenhagen, Denmark;
110.Steno Diabet Ctr, Gentofte, Denmark;
111.Southern Denmark Univ, Natl Inst Publ Hlth, Copenhagen, Denmark;
112.Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands;
113.Interuniv Cardiol Inst Netherlands, Utrecht, Netherlands;
114.Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Copenhagen, Denmark;
115.Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Copenhagen Gen Populat Study, Copenhagen, Denmark;
116.Univ Helsinki, Dept Med, Helsinki, Finland;
117.Univ Helsinki, Abdominal Ctr Endocrinol, Helsinki, Finland;
118.Minerva Fdn, Helsinki, Finland;
119.Kuopio Univ Hosp, Kuopio, Finland;
120.Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England;
121.Univ Oxford, Radcliffe Dept Med, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England;
122.Oxford Univ Hosp, Oxford NIHR Biomed Res Ctr, Oxford, England;
123.Queens Univ, UKCRC Ctr Excellence Publ Hlth, Belfast, Antrim, North Ireland;
124.VA Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr MA, Boston, MA USA;
125.Natl Inst Hlth & Welf, Dept Hlth, Helsinki, Finland;
126.Univ Helsinki, Cent Hosp, Helsinki, Finland;
127.Imperial Coll London, Hammersmith Hosp, Natl Heart & Lung Inst, London, England;
128.Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;
129.Univ Eastern Finland, Inst Clin Med Internal Med, Kuopio, Finland;
130.Univ Eastern Finland, Inst Biomed, Dept Physiol, Kuopio Campus, Kuopio, Finland;
131.Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, Kuopio, Finland;
132.Univ Cambridge, Sch Clin Med, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England;
133.Univ Aarhus, Sect Gen Practice, Dept Publ Hlth, Aarhus, Denmark;
134.Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark;
135.Res Ctr Prevent & Hlth, Copenhagen, Denmark;
136.Ichan Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY USA;
137.Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Fuwai Hosp, State Key Lab Cardiovasc Dis, Beijing, Peoples R China;
138.Peking Union Med Coll, Beijing, Peoples R China;
139.Karolinska Inst, Dept Med, Cardiovasc Med Unit, Cardiovasc Genet & Genom Grp, Stockholm, Sweden;
140.Pfizer Worldwide R&D, Pharmatherapeut Clin Res, Sollentuna, Sweden;
141.Univ Virginia, Ctr Publ Hlth Gen, Charlottesville, VA USA;
142.Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA;
143.Univ Eastern Finland, Unit Primary Hlth Care, Kuopio, Finland;
144.Kuopio Univ Hosp, Kuopio, Finland;
145.Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England;
146.Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England;
147.Massachusetts Gen Hosp, Div Gen Internal Med, Boston, MA 02114 USA;
148.Lund Univ, Clin Res Ctr, Univ Hosp Malmo, Dept Clin Sci, Malmo, Sweden;
149.Ludwig Maximilians Univ Munchen, Dept Med 1, Munich, Germany;
150.Munich Heart Alliance, DZHK German Ctr Cardiovasc Res, Munich, Germany;
151.Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England;
152.Natl Ctr Cardiovasc Invest, Dept Cardiovasc Epidemiol & Populat Genet, Madrid, Spain;
153.Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr, Nutr & Genom Lab, Boston, MA 02111 USA;
154.Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA;
155.Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland;
156.Imperial Coll London, Internat Ctr Circulatory Hlth, London, England;
157.Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA;
158.Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA;
159.Univ Penn, Dept Genet, Perelman Sch Med, Philadelphia, PA USA;
160.Univ Penn, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USA;
161.Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA;
162.Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA;
163.Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA;
164.Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore;
165.Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, Amsterdam, Netherlands;
166.Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England;
167.Univ Dundee, Ninewells Hosp & Med Sch, Div Populat Hlth Sci, Dundee, Scotland;
168.Univ Edinburgh, Ctr Genom & Expt Med, Generat Scotland, Edinburgh, Midlothian, Scotland;
169.Univ Michigan, Dept Internal Med, Div Gastroenterol, Ann Arbor, MI 48109 USA;
170.Univ Edinburgh, Alzheimer Scotland Dementia Res Ctr, Edinburgh, Midlothian, Scotland;
171.Washington Univ, Sch Med, Div Cardiovasc, Dept Med, St Louis, MO 63110 USA;
172.Washington Univ, Sch Med, Div Cardiovasc, Dept Genet, St Louis, MO 63110 USA;
173.Washington Univ, Sch Med, McDonnell Genome Inst, St Louis, MO USA;
174.Ludwig Maximilians Univ Munchen, Fac Med, IBE, Munich, Germany;
175.Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, Neuherberg, Germany;
176.Kanazawa Univ, Grad Sch Med, Div Cardiovasc Med, Kanazawa, Ishikawa, Japan;
177.Leiden Univ, Med Ctr, Dept Gerontol & Geriatr, Leiden, Netherlands;
178.Natl Inst Hlth & Welf, Chron Dis Prevent Unit, Helsinki, Finland;
179.King Abdulaziz Univ, Fahd Med Res Ctr, Saudi Diabet Res Grp, Jeddah, Saudi Arabia;
180.Copenhagen Univ Hosp, Rigshosp, Dept Cardiol, Heart Ctr, Copenhagen, Denmark;
181.Indiana Univ, Dept Epidemiol, Fairbanks Sch Publ Hlth, Indianapolis, IN 46204 USA;
182.Indiana Univ, Sch Med, Dept Med, Indianapolis, IN USA;
183.Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Jackson, MS 39216 USA;
184.Atlanta VA Med Ctr, Decatur, GA USA;
185.Emory Clin, Cardiovasc Res Inst, Atlanta, GA 30322 USA;
186.Peking Univ, Hosp 3, Inst Vasc Med, Dept Cardiol,Key Lab Mol Cardiovasc Sci,Minist Ed, Beijing, Peoples R China;
187.Yale Univ, Yale Coll, New Haven, CT USA;
188.Massachusetts Gen Hosp, Ctr Regenerat Med, Boston, MA 02114 USA;
189.King Abdulaziz Univ, Princess Al Jawhara Al Brahim Ctr Excellence Res, Jeddah, Saudi Arabia;
190.Lillebaelt Hosp, Med Dept, Vejle, Denmark;
191.Univ Sassari, Dipartimento Sci Biomed, Sassari, Italy;
192.Corporal Michael Crescenz VA Med Ctr, Philadelphia, PA USA;
193.Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA
Recommended Citation
GB/T 7714
Liu, Dajiang J.,Peloso, Gina M.,Yu, Haojie,et al. Exome-wide association study of plasma lipids in > 300,000 individuals[J]. NATURE GENETICS,2017,49(12):1758-+.
APA Liu, Dajiang J..,Peloso, Gina M..,Yu, Haojie.,Butterworth, Adam S..,Wang, Xiao.,...&Kathiresan, Sekar.(2017).Exome-wide association study of plasma lipids in > 300,000 individuals.NATURE GENETICS,49(12),1758-+.
MLA Liu, Dajiang J.,et al."Exome-wide association study of plasma lipids in > 300,000 individuals".NATURE GENETICS 49.12(2017):1758-+.
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