IR@PKUHSC  > 北京大学护理学院
学科主题护理学
Association of apolipoprotein E genotype with outcome in hospitalized ischemic stroke patients
Zhang, Yajing1,2,3; Liu, Shuling2,3,4; Yue, Wei2,3; Shi, Zhihong2,3; Guan, Yalin2,3; Li, Mingzi4; Ji, Yong2,3; Li, Xin1
通讯作者Ji, Yong(2,3) ; Li, Xin(1)
关键词apolipoprotein E ischemic stroke NIHSS outcome
刊名MEDICINE
2017-12-01
DOI10.1097/MD.0000000000008964
96期:50
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]AMYOTROPHIC-LATERAL-SCLEROSIS ; TRAUMATIC BRAIN-INJURY ; APOE GENOTYPE ; ALZHEIMERS-DISEASE ; E POLYMORPHISM ; CEREBROVASCULAR-DISEASE ; CEREBRAL INFARCTION ; TYPE-4 ALLELE ; E ISOFORMS ; METAANALYSIS
英文摘要

The aim of this study was to study the ability of the genotype to predict impairment and disability in hospitalized ischemic stroke (IS) patients after hospital discharge and 6 months after the onset of stroke symptoms.

A total of 786 patients with a first IS were enrolled. Apolipoprotein E (ApoE) polymorphism was examined using polymerase chain reaction. Stroke subtype was classified using the Oxfordshire Community Stroke Project classification scheme and the Trial of Org 10172 in Acute Stroke Treatment criteria. Impairment as assessed using the National Institutes of Health Stroke Scale (NIHSS), and disability as measured using the modified Rankin Scale (mRS), were compared against the ApoE genotype.

There was no significant association between the type of ApoE allele present and the stroke subtype. On multivariate regression analysis, the apolipoprotein E*E4 allele genotype did not predict poor outcome at discharge and or at 6 months after stroke onset. A higher NIHSS score on admission, older age, and higher fasting glucose levels did predict poor outcome at hospital discharge. Higher glucose levels and higher NIHSS scores on admission were independent risk factors predicting poor neurologic status at 6 months after stroke onset.

The presence of the apolipoprotein E*E4 and apolipoprotein E*E2 genotypes, although related to cholesterol and triglyceride levels, do not affect recovery during rehabilitation. A higher NIHSS score on admission and a higher fasting glucose level predict poor neurologic status, both at hospital discharge and 6 months after onset.

语种英语
原文出处查看原文
WOS记录号WOS:000422990500040
通讯作者邮箱jiyongusa@sina.comhhyyfirst@aliyun.com
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/135387
专题北京大学护理学院
作者单位1.Tianjin Huanhu Hosp, Dept Neurol, Tianjin, Peoples R China;
2.Peking Univ, Sch Nursing, Beijing, Peoples R China;
3.Tianjin Med Univ, Hosp 2, Dept Neurol, 23 Pingjiang Rd, Tianjin 300211, Peoples R China;
4.Tianjin Huanhu Hosp, Tianjin Key Lab Cerebrovasc Dis & Neurodegenerat, Tianjin, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Yajing,Liu, Shuling,Yue, Wei,et al. Association of apolipoprotein E genotype with outcome in hospitalized ischemic stroke patients[J]. MEDICINE,2017,96(50).
APA Zhang, Yajing.,Liu, Shuling.,Yue, Wei.,Shi, Zhihong.,Guan, Yalin.,...&Li, Xin.(2017).Association of apolipoprotein E genotype with outcome in hospitalized ischemic stroke patients.MEDICINE,96(50).
MLA Zhang, Yajing,et al."Association of apolipoprotein E genotype with outcome in hospitalized ischemic stroke patients".MEDICINE 96.50(2017).
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
10.1097@MD.000000000(212KB)期刊论文出版稿开放获取CC BY浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Yajing]的文章
[Liu, Shuling]的文章
[Yue, Wei]的文章
百度学术
百度学术中相似的文章
[Zhang, Yajing]的文章
[Liu, Shuling]的文章
[Yue, Wei]的文章
必应学术
必应学术中相似的文章
[Zhang, Yajing]的文章
[Liu, Shuling]的文章
[Yue, Wei]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 10.1097@MD.0000000000008964.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。