学科主题药学
Nuclear translocation of DJ-1 protects adult neuronal stem cells in an MPTP mouse model of Parkinson′s disease
Sun, Yi1,2; Wang, Yupeng1,2; Zhao, Xin1,2; Pu, Xiaoping1,2
通讯作者Sun, Yi(1,2)
关键词DJ-1 neurogenesis neuronal stem cell nuclear translocation Parkinson&prime s disease
刊名NEUROREPORT
2018-03-07
DOI10.1097/WNR.0000000000000956
29期:4页:301-307
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]OLFACTORY-BULB ; EXPRESSION ; BRAIN
英文摘要

DJ-1, originally identified as an oncogene product, is involved in multiple processes, including cellular transformation, the oxidative stress response, and transcriptional regulation. We had previously found that DJ-1 was closely associated with the proliferation and differentiation of cultured neuronal stem cells. In this study, we further investigated the functions of DJ-1 to determine how adult neurogenesis was affected in the subgranular zones (SGZ), subventricular zone (SVZ), and olfactory bulb (OB), which are brain areas closely related to early nonmotor symptoms of Parkinson′s disease, using a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson′s disease. The results showed that the numbers of 5-bromo-2-deoxyuridine-positive (BrdU(+)) cells in the SGZ and SVZ of mice in the MPTP group were not significantly different from those in the saline controls, whereas the number of BrdU(+) cells in the olfactory granule cell layer and glomerulus layer of the OB in the MPTP group changed markedly. We also found that DJ-1 was translocated into the nuclei of BrdU(+) cells in the SGZ and SVZ, but not in the OB. This may indicate that the nuclear translocation of DJ-1 in the SGZ and SVZ protects adult neuronal stem cells from damage caused by MPTP so that the normal number is maintained, but is not involved in the protective mechanism in the OB.

语种英语
WOS记录号WOS:000425661500010
通讯作者邮箱sunyi@bjmu.edu.cn
第一作者单位Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China ; Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, 38 Xue Yuan Rd, Beijing 100191, Peoples R China
通讯作者单位Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China ; Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, 38 Xue Yuan Rd, Beijing 100191, Peoples R China
ISSN0959-4965
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/136275
专题北京大学药学院_天然药物与仿生药物国家重点实验室
北京大学药学院_分子与细胞药理学系
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China;
2.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, 38 Xue Yuan Rd, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Sun, Yi,Wang, Yupeng,Zhao, Xin,et al. Nuclear translocation of DJ-1 protects adult neuronal stem cells in an MPTP mouse model of Parkinson′s disease[J]. NEUROREPORT,2018,29(4):301-307.
APA Sun, Yi,Wang, Yupeng,Zhao, Xin,&Pu, Xiaoping.(2018).Nuclear translocation of DJ-1 protects adult neuronal stem cells in an MPTP mouse model of Parkinson′s disease.NEUROREPORT,29(4),301-307.
MLA Sun, Yi,et al."Nuclear translocation of DJ-1 protects adult neuronal stem cells in an MPTP mouse model of Parkinson′s disease".NEUROREPORT 29.4(2018):301-307.
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