IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Prognostic value of PD-L1 expression in combination with CD8(+) TILs density in patients with surgically resected non-small cell lung cancer
Yang, Hui1,2; Shi, Jinpeng1,2; Lin, Dongmei3; Li, Xuefei2,4; Zhao, Chao2,4; Wang, Qi5; Zhang, Limin1,2; Jiang, Tao1,2; Zhao, Sha1,2; Liu, Xiaozhen1,2; Jia, Yijun1,2; Zhang, Yajun6; Cai, Weijing1,2; Zhou, Caicun1,2
关键词Cd8 Non-small Cell Lung Cancer Prognosis Programmed Cell Death Ligand-1 Tumor Infiltrating Lymphocytes
刊名CANCER MEDICINE
2018
DOI10.1002/cam4.1243
7期:1页:32-45
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]Tumor-infiltrating Lymphocytes ; Death-ligand 1 ; Pulmonary Adenocarcinoma ; Clinicopathological Analysis ; Poor-prognosis ; Egfr-tkis ; T-cells ; Association ; Docetaxel ; Pembrolizumab
英文摘要

To investigate the prognostic value of PD-L1 expression combined with CD8(+) TILs density in patients with resected NSCLC and correlations with clinicopathological features. We retrospectively enrolled 178 patients with resected NSCLC from 2011 to 2015. All surgical primary and 58 matched metastatic lymph node specimens were tested for PD-L1, CD8(+) TILs, and oncogenic alterations. PD-(L)1+ was detected in 71 (39.9%) and CD8(high) TILs in 74 (41.6%) cases. Smoking, SqCC, and EGFR-were associated with both PD-L1(+) and CD8(high) TILs. Patients with CD8(high) TILs had longer OS (P = 0.012). PD-L1(-) was significantly associated with longer OS in patients with oncogenic alterations (P = 0.047). By multivariate analysis, CD8(high) TILs (HR = 0.411; 95% CI, 0.177-0.954; P = 0.038), rather than PD-L1, was the independent predictive factor for OS. The longest and shortest OS were achieved in patients with PD-L1(+)/CD8(high) and PD-L1(+)/CD8(low),respectively (P = 0.025). Inconsistent PD-L1 expression levels were observed in 23 of 58 (39.7%) patients with primary and matched metastatic lymph node specimens. Of them, CD8(high) TILs was significantly associated with longer OS in patients with metastatic lymph nodes and/or consistent PD-L1 expression (P = 0.017 and 0.049, respectively). The combination of PD-L1 and CD8(+) TILs density, instead of PD-L1 alone, suggested impressive prognostic values in NSCLC patients. Less than half of patients with resected NSCLC experienced inconsistent PD-L1 expression between primary and metastatic lesions. The level of PD-L1 expression in advanced NSCLC needs to be evaluated more comprehensively.

语种英语
WOS记录号WOS:000425822300004
通讯作者邮箱ycsyzyj@126.com ; caiweijing816@163.com ; caicunzhoudr@yeah.net
ISSN2045-7634
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
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条目标识符http://ir.bjmu.edu.cn/handle/400002259/136285
专题北京大学临床肿瘤学院
作者单位1.Tongji Univ, Shanghai Pulm Hosp, Dept Med Oncol, Sch Med, Shanghai 200433, Peoples R China;
2.Tongji Univ, Thorac Canc Inst, Sch Med, Shanghai 200433, Peoples R China;
3.Peking Univ, Key Lab Carcinogenesis & Translat Res, Canc Hosp & Inst, Minist Educ, Beijing 100142, Peoples R China;
4.Tongji Univ, Sch Med, Shanghai Pulm Hosp, Dept Lung Canc & Immunol, Shanghai 200433, Peoples R China;
5.Yancheng Third Peoples Hosp, Dept Pathol, Yancheng 224001, Peoples R China;
6.Yancheng Third Peoples Hosp, Dept Thorac Surg, 75 Juchang Rd, Yancheng 224001, Jiangsu, Peoples R China
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GB/T 7714
Yang, Hui,Shi, Jinpeng,Lin, Dongmei,et al. Prognostic value of PD-L1 expression in combination with CD8(+) TILs density in patients with surgically resected non-small cell lung cancer[J]. CANCER MEDICINE,2018,7(1):32-45.
APA Yang, Hui.,Shi, Jinpeng.,Lin, Dongmei.,Li, Xuefei.,Zhao, Chao.,...&Zhou, Caicun.(2018).Prognostic value of PD-L1 expression in combination with CD8(+) TILs density in patients with surgically resected non-small cell lung cancer.CANCER MEDICINE,7(1),32-45.
MLA Yang, Hui,et al."Prognostic value of PD-L1 expression in combination with CD8(+) TILs density in patients with surgically resected non-small cell lung cancer".CANCER MEDICINE 7.1(2018):32-45.
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