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The Interaction of PPAR alpha and CYP7B1 with ER alpha, beta Impacted the Occurrence and Development of Intrahepatic Cholestasis in Pregnant Rats
Song, Zhaoyi1; Shi, Qingyun2
通讯作者Shi, Qingyun(2)
关键词intrahepatic cholestasis of pregnancy 17 alpha-ethynylestradiol estrogen receptor alpha estrogen receptor beta oxysterol 7alpha-hydroxylase peroxisome proliferator-activated receptor alpha small interfering RNA
刊名REPRODUCTIVE SCIENCES
2017-04-01
DOI10.1177/1933719116667223
24期:4页:627-634
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]ESTROGEN-RECEPTOR-ALPHA ; PRIMARY BILIARY-CIRRHOSIS ; RETINOID-X-RECEPTOR ; CROSS-TALK ; MEDIATED REGULATION ; SIGNALING PATHWAYS ; CANCER-CELLS ; GENE ; 27-HYDROXYCHOLESTEROL ; EXPRESSION
英文摘要

Intrahepatic cholestasis of pregnancy (ICP) is a disorder of bile acid (BA) synthesis, excretion, and metabolism, with systemic accumulation of BAs, which can lead to prematurity, fetal distress, and intrauterine death. Here, we investigate the expression of peroxisome proliferator-activated receptor alpha and cytochrome P450 oxysterol 7alpha-hydroxylase by exposing to 17 alpha-ethynylestradiol with or without the estrogen receptor signaling pathway in pregnant rats with intrahepatic cholestasis. In vivo and in vitro evidences showed that estrogen receptor alpha (ER alpha) may be the key point of occurrence and development of intrahepatic cholestasis in pregnant rats. Besides, the abnormalities in genes could be reversed by ER alpha small interfering RNA. Our findings provide the ER alpha-centered hypothesis on the mechanisms of ICP. New perspectives are emerging for the treatment of estrogen-induced hepatic complication.

语种英语
WOS记录号WOS:000399045200017
通讯作者邮箱shiqingyun@hotmail.com
第一作者单位Peking Univ, Sch Clin Med 9, Dept Obstet & Gynecol, Beijing, Peoples R China
通讯作者单位Beijing Shijitan Hosp, Capital Med Univ, Dept Obstet & Gynecol, 10 Tieyi Rd, Beijing 100038, Peoples R China
ISSN1933-7191
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/139726
专题北京大学第九临床医学院
作者单位1.Peking Univ, Sch Clin Med 9, Dept Obstet & Gynecol, Beijing, Peoples R China;
2.Beijing Shijitan Hosp, Capital Med Univ, Dept Obstet & Gynecol, 10 Tieyi Rd, Beijing 100038, Peoples R China
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GB/T 7714
Song, Zhaoyi,Shi, Qingyun. The Interaction of PPAR alpha and CYP7B1 with ER alpha, beta Impacted the Occurrence and Development of Intrahepatic Cholestasis in Pregnant Rats[J]. REPRODUCTIVE SCIENCES,2017,24(4):627-634.
APA Song, Zhaoyi,&Shi, Qingyun.(2017).The Interaction of PPAR alpha and CYP7B1 with ER alpha, beta Impacted the Occurrence and Development of Intrahepatic Cholestasis in Pregnant Rats.REPRODUCTIVE SCIENCES,24(4),627-634.
MLA Song, Zhaoyi,et al."The Interaction of PPAR alpha and CYP7B1 with ER alpha, beta Impacted the Occurrence and Development of Intrahepatic Cholestasis in Pregnant Rats".REPRODUCTIVE SCIENCES 24.4(2017):627-634.
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