IR@PKUHSC  > 北京大学第九临床医学院
学科主题临床医学
Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing
Zheng, Chunhong1,2; Zheng, Liangtao3; Yoo, Jae-Kwang4; Guo, Huahu5,6,7; Zhang, Yuanyuan1,2; Guo, Xinyi1,2; Kang, Boxi1,2; Hu, Ruozhen4; Huang, Julie Y.4; Zhang, Qiming1,2; Liu, Zhouzerui1,2; Dong, Minghui1,2; Hu, Xueda1,2; Ouyang, Wenjun4; Peng, Jirun5,6,7; Zhang, Zemin1,2,3
通讯作者Ouyang, Wenjun(4) ; Peng, Jirun(5,6,7) ; Zhang, Zemin(1,2,3)
刊名CELL
2017-06-15
DOI10.1016/j.cell.2017.05.035
169期:7页:1342-+
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]IMMUNE CHECKPOINT BLOCKADE ; RNA-SEQ ANALYSIS ; HEPATOCELLULAR-CARCINOMA ; MAIT CELLS ; IMMUNOTHERAPY ; LYMPHOCYTES ; EXHAUSTION ; THERAPY ; IMMUNOPATHOGENESIS ; EXPRESSION
英文摘要

Systematic interrogation of tumor-infiltrating lymphocytes is key to the development of immunotherapies and the prediction of their clinical responses in cancers. Here, we perform deep single-cell RNA sequencing on 5,063 single T cells isolated from peripheral blood, tumor, and adjacent normal tissues from six hepatocellular carcinoma patients. The transcriptional profiles of these individual cells, coupled with assembled T cell receptor (TCR) sequences, enable us to identify 11 T cell subsets based on their molecular and functional properties and delineate their developmental trajectory. Specific subsets such as exhausted CD8(+) T cells and Tregs are preferentially enriched and potentially clonally expanded in hepatocellular carcinoma (HCC), and we identified signature genes for each subset. One of the genes, layilin, is upregulated on activated CD8(+) T cells and Tregs and represses the CD8(+) T cell functions in vitro. This compendium of transcriptome data provides valuable insights and a rich resource for understanding the immune landscape in cancers.

语种英语
WOS记录号WOS:000403332400021
通讯作者邮箱wouyang@amgen.com ; pengjr@medmail.com.cn ; zemin@pku.edu.cn
第一作者单位Peking Univ, Sch Life Sci, Beijing 100871, Peoples R China ; Peking Univ, BIOPIC, Beijing Adv Innovat Ctr Genom, Beijing 100871, Peoples R China
通讯作者单位Peking Univ, Sch Clin Med 9, Beijing 100038, Peoples R China ; Peking Univ, Sch Life Sci, Beijing 100871, Peoples R China ; Amgen Inc, Dept Inflammat & Oncol, San Francisco, CA 94080 USA ; Peking Univ, BIOPIC, Beijing Adv Innovat Ctr Genom, Beijing 100871, Peoples R China ; Peking Univ, Acad Adv Interdisciplinary Studies, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China ; Capital Med Univ, Beijing Shijitan Hosp, Dept Surg, Beijing 100038, Peoples R China ; Capital Med Univ, Sch Oncol, Beijing 100038, Peoples R China
ISSN0092-8674
引用统计
被引频次:53[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/139789
专题北京大学第九临床医学院
作者单位1.Peking Univ, Sch Clin Med 9, Beijing 100038, Peoples R China;
2.Peking Univ, Sch Life Sci, Beijing 100871, Peoples R China;
3.Amgen Inc, Dept Inflammat & Oncol, San Francisco, CA 94080 USA;
4.Peking Univ, BIOPIC, Beijing Adv Innovat Ctr Genom, Beijing 100871, Peoples R China;
5.Peking Univ, Acad Adv Interdisciplinary Studies, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China;
6.Capital Med Univ, Beijing Shijitan Hosp, Dept Surg, Beijing 100038, Peoples R China;
7.Capital Med Univ, Sch Oncol, Beijing 100038, Peoples R China
推荐引用方式
GB/T 7714
Zheng, Chunhong,Zheng, Liangtao,Yoo, Jae-Kwang,et al. Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing[J]. CELL,2017,169(7):1342-+.
APA Zheng, Chunhong.,Zheng, Liangtao.,Yoo, Jae-Kwang.,Guo, Huahu.,Zhang, Yuanyuan.,...&Zhang, Zemin.(2017).Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing.CELL,169(7),1342-+.
MLA Zheng, Chunhong,et al."Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing".CELL 169.7(2017):1342-+.
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