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学科主题临床医学
Evaluation of insulin resistance improvement after laparoscopic sleeve gastrectomy or gastric bypass surgery with HOMA-IR
Zhu, Yubing; Sun, Zhipeng; Du, Yanmin; Xu, Guangzhong; Gong, Ke; Zhu, Bin; Zhang, Nengwei
通讯作者Zhang, Nengwei(1)
关键词Laparoscopic sleeve gastrectomy (LSG) laparoscopic gastric bypass (LGB) type 2 diabetes homeostasis model of insulin resistance index (HOMA-IR)
刊名BIOSCIENCE TRENDS
2017-12-01
DOI10.5582/bst.2017.01307
11期:6页:675-681
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biology
研究领域[WOS]Life Sciences & Biomedicine - Other Topics
关键词[WOS]HOMEOSTASIS MODEL ASSESSMENT ; METABOLIC SYNDROME ; BARIATRIC SURGERY ; POPULATION ; ADOLESCENTS ; PEPTIDE ; RISK
英文摘要

Our purpose was to explore the remission of insulin resistance after bariatric surgery to discover the mechanism of diabetes remission excluding dietary factors. A retrospective case control study was conducted on patients with type 2 diabetes, who underwent laparoscopic sleeve gastrectomy (LSG) or laparoscopic gastric bypass surgery (LGB) in Beijing Shijitan Hospital from April 1, 2012 to April 1, 2013. The laboratory and anthropometric data was analyzed pre-surgery and during a 2-year follow-up. HOMA-IR was calculated and evaluated. The two surgical procedures were compared. No significant difference in complete remission rate was observed between the two groups (LGB group: 62.1%, LSG group: 60.0%, p = 0.892). HOMA-IR was reduced to a stable level at the 3rd month after surgery. The cut-off value of HOMA-IR was 2.38 (sensitivity: 0.938, specificity: 0.75) and 2.33 (sensitivity: 0.941, specificity: 0.778) respectively for complete remission after LSG or LGB surgery. Insulin resistance was improved while GLP-1 and Ghrelin was changed significantly in patients with type 2 diabetes prior to weight loss either in the LSG or LGB group. HOMA-IR decreased to less than the cut-off value at the 3rd month and was closely related to complete remission. The mechanism of bariatric surgery was not due just to simply dietary factors or body weight loss but also the remission of insulin resistance.

语种英语
WOS记录号WOS:000423758300009
通讯作者邮箱zhangnw1@sohu.com
ISSN1881-7815
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/140346
专题北京大学第九临床医学院
北京大学口腔医学院_口腔放射科
作者单位Peking Univ, Diabet Surg Ctr, Gen Surg Dept, Sch Clin Med 9,Beijing Shijitan Hosp,Capital Med, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Zhu, Yubing,Sun, Zhipeng,Du, Yanmin,et al. Evaluation of insulin resistance improvement after laparoscopic sleeve gastrectomy or gastric bypass surgery with HOMA-IR[J]. BIOSCIENCE TRENDS,2017,11(6):675-681.
APA Zhu, Yubing.,Sun, Zhipeng.,Du, Yanmin.,Xu, Guangzhong.,Gong, Ke.,...&Zhang, Nengwei.(2017).Evaluation of insulin resistance improvement after laparoscopic sleeve gastrectomy or gastric bypass surgery with HOMA-IR.BIOSCIENCE TRENDS,11(6),675-681.
MLA Zhu, Yubing,et al."Evaluation of insulin resistance improvement after laparoscopic sleeve gastrectomy or gastric bypass surgery with HOMA-IR".BIOSCIENCE TRENDS 11.6(2017):675-681.
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