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Markers of Iron Status Are Associated with Risk of Hyperuricemia among Chinese Adults: Nationwide Population-Based Study
Li, Xiangping1; He, Tingchao2; Yu, Kai2; Lu, Qian1; Alkasir, Rashad3; Guo, Guifang1; Xue, Yong2,3
通讯作者Guo, Guifang(1) ; Xue, Yong(2,3)
关键词serum uric acid serum ferritin hyperuricemia the China Health and Nutrition Survey iron overload
刊名NUTRIENTS
2018-02-01
DOI10.3390/nu10020191
10期:2
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nutrition & Dietetics
研究领域[WOS]Nutrition & Dietetics
关键词[WOS]SERUM URIC-ACID ; XANTHINE-OXIDASE ACTIVITY ; CROSS-SECTIONAL ANALYSIS ; PUBLIC-HEALTH PRACTICE ; NUTRITION SURVEY CHNS ; ACUTE-PHASE RESPONSE ; C-REACTIVE PROTEIN ; CARDIOVASCULAR-DISEASE ; METABOLIC SYNDROME ; GENERAL-POPULATION
英文摘要

Background: Elevated serum uric acid (SUA) involved in iron metabolism, has been increasingly recognized as a risk factor for gout and cardiovascular diseases. The objective of this study was to examine the associations between markers of iron status with risk of hyperuricemia (HU) in Chinese adult population. Methods: Data were extracted from the 2009 wave of the China Health and Nutrition Survey, consisting of 7946 apparently healthy adults. Serum ferritin (SF), transferrin, soluble transferrin receptors (sTfR), hemoglobin (Hb), high-sensitivity C-reactive protein (hs-CRP), and SUA were measured. Diet was assessed with three consecutive 24 h recalls. Demographic characteristics, smoking status, alcohol consumption, and physical activities were investigated using a structured questionnaire. Multilevel mixed-effects models were constructed to estimate the associations of SF, transferrin, sTfR, and Hb with SUA and the risk of HU. Results: The crude prevalence of HU was 16.1%. SF, transferrin, and Hb levels were positively associated with SUA and the risk of HU after adjustment for cluster effects and potential confounders (all p-trend < 0.05). Compared with participants in the lowest quartile of SF, those in the highest quartile had significantly higher SUA concentrations ( = 0.899 mg/dL, 95% confidence interval (CI): 0.788, 1.010; p < 0.001) and higher risk of HU (odds ratio (OR) = 3.086, 95% CI: 2.450, 3.888; p < 0.001). Participants with the highest quartile of transferrin had significantly higher SUA concentrations ( = 0.488 mg/dL, 95% CI: 0.389, 0.587; p < 0.001) and higher risk of HU (OR: 1.900; 95% CI: 1.579, 2.286; p < 0.001) when compared with those with the lowest quartile. In male participants, those in the highest quartile of Hb had significantly higher risk of HU when compared to the reference group (OR: 1.401, 95% CI: 1.104, 1.777; p < 0.01); however, this association was not found in female participants (OR: 1.093; 95% CI: 0.821, 1.455; p = 0.544). Conclusion: SF, transferrin, and Hb levels were positively associated with the risk of HU, and additional studies are needed to confirm the findings, as well as to elucidate their underlying mechanisms.

语种英语
WOS记录号WOS:000427540000081
通讯作者邮箱gguo@bjmu.edu.cn ; xueyong1986@im.ac.cn
第一作者单位Peking Univ, Sch Nursing, 38 Xueyuan Rd, Beijing 100191, Peoples R China
通讯作者单位Peking Univ, Sch Nursing, 38 Xueyuan Rd, Beijing 100191, Peoples R China ; Peking Univ, Sch Publ Hlth, Hlth Sci Ctr, Dept Nutr & Food Hyg, 38 Xueyuan Rd, Beijing 100191, Peoples R China ; Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, 1 Beichen West Rd, Beijing 100101, Peoples R China
ISSN2072-6643
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/140530
专题北京大学护理学院
北京大学护理学院_护理学院
作者单位1.Peking Univ, Sch Nursing, 38 Xueyuan Rd, Beijing 100191, Peoples R China;
2.Peking Univ, Sch Publ Hlth, Hlth Sci Ctr, Dept Nutr & Food Hyg, 38 Xueyuan Rd, Beijing 100191, Peoples R China;
3.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, 1 Beichen West Rd, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714
Li, Xiangping,He, Tingchao,Yu, Kai,et al. Markers of Iron Status Are Associated with Risk of Hyperuricemia among Chinese Adults: Nationwide Population-Based Study[J]. NUTRIENTS,2018,10(2).
APA Li, Xiangping.,He, Tingchao.,Yu, Kai.,Lu, Qian.,Alkasir, Rashad.,...&Xue, Yong.(2018).Markers of Iron Status Are Associated with Risk of Hyperuricemia among Chinese Adults: Nationwide Population-Based Study.NUTRIENTS,10(2).
MLA Li, Xiangping,et al."Markers of Iron Status Are Associated with Risk of Hyperuricemia among Chinese Adults: Nationwide Population-Based Study".NUTRIENTS 10.2(2018).
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