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Changes in total homocysteine levels after acute stroke and recurrence of stroke
Shi, Zhihong1,2,3; Liu, Shuling1,2,3,6; Guan, Yalin1,3; Zhang, Meilin4; Lu, Hui1,2,3; Yue, Wei1,2,3; Zhang, Biao5; Li, Mingzi6; Xue, Jing5; Ji, Yong1,2,3
通讯作者Xue, Jing(5) ; Ji, Yong(1,2,3)
刊名SCIENTIFIC REPORTS
2018-05-03
DOI10.1038/s41598-018-25398-5
8
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]ACUTE MYOCARDIAL-INFARCTION ; ACUTE ISCHEMIC-STROKE ; PLASMA HOMOCYSTEINE ; CARDIOVASCULAR-DISEASE ; NORTHERN MANHATTAN ; VASCULAR EVENTS ; HEART-DISEASE ; RISK-FACTOR ; FOLIC-ACID ; HOMOCYST(E)INE
英文摘要

It is not known how total homocysteine (tHcy) levels change during the transition from acute stroke to post-stroke convalescence or whether tHcy changes occurring after the acute period are associated with recurrence of cerebro-cardiovascular events. Levels of tHcy were measured during acute ischemia and again after three months. Patients were followed for a median of 18 (range: 12-36) months. A total of 2800 patients who had at least two tHcy measurements were enrolled between February 2012 and June 2014; 2587 patients presented with ischemic stroke and 213 presented with cerebral hemorrhage. During the follow-up period, 220 (7.9%) patients experienced another ischemic event. After adjusting for additional cardiovascular risk factors, patients with the highest levels of tHcy (fourth quartile; > 15.5 mu mol/L) had a 1.76-fold increased risk of a recurrence (adjusted HR: 1.76, 95% CI: 1.11-3.08) as compared to patients with the lowest levels of tHcy (lowest quartile; <= 9.65 mu mol/L). Additional analysis by subgroup indicated that this correlation was only significant for patients with large-artery atherosclerosis ischemia (adjusted HR: 2.00, 95% CI: 1.13-3.55). Elevated tHcy during the convalescent phase of acute stroke was independently associated with an increased risk of recurrent ischemic stroke, especially in those patients with large-vessel atherosclerosis ischemia.

语种英语
WOS记录号WOS:000431291500045
通讯作者邮箱tjxj@163.com ; jiyongusa@126.com
第一作者单位Tianjin Huanhu Hosp, Dept Neurol, Tianjin, Peoples R China ; Tianjin Huanhu Hosp, Tianjin Dementia Inst, Tianjin, Peoples R China ; Tianjin Huanhu Hosp, Tianjin Key Lab Cerebrovasc & Neurodegenerat Dis, Tianjin, Peoples R China
通讯作者单位Tianjin Huanhu Hosp, Dept Neurol, Tianjin, Peoples R China ; Tianjin Huanhu Hosp, Tianjin Dementia Inst, Tianjin, Peoples R China ; Tianjin Huanhu Hosp, Dept Clin Lab, Tianjin, Peoples R China ; Tianjin Huanhu Hosp, Tianjin Key Lab Cerebrovasc & Neurodegenerat Dis, Tianjin, Peoples R China
ISSN2045-2322
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/140789
专题北京大学护理学院
作者单位1.Peking Univ, Sch Nursing, Beijing, Peoples R China;
2.Tianjin Huanhu Hosp, Dept Neurol, Tianjin, Peoples R China;
3.Tianjin Huanhu Hosp, Tianjin Dementia Inst, Tianjin, Peoples R China;
4.Tianjin Huanhu Hosp, Dept Clin Lab, Tianjin, Peoples R China;
5.Tianjin Huanhu Hosp, Tianjin Key Lab Cerebrovasc & Neurodegenerat Dis, Tianjin, Peoples R China;
6.Tianjin Med Univ, Sch Publ Hlth, Dept Nutr & Food Sci, Tianjin, Peoples R China
推荐引用方式
GB/T 7714
Shi, Zhihong,Liu, Shuling,Guan, Yalin,et al. Changes in total homocysteine levels after acute stroke and recurrence of stroke[J]. SCIENTIFIC REPORTS,2018,8.
APA Shi, Zhihong.,Liu, Shuling.,Guan, Yalin.,Zhang, Meilin.,Lu, Hui.,...&Ji, Yong.(2018).Changes in total homocysteine levels after acute stroke and recurrence of stroke.SCIENTIFIC REPORTS,8.
MLA Shi, Zhihong,et al."Changes in total homocysteine levels after acute stroke and recurrence of stroke".SCIENTIFIC REPORTS 8(2018).
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