IR@PKUHSC  > 北京大学第三临床医学院  > 中医科
学科主题临床医学
Contralateral Electroacupuncture Relieves Chronic Neuropathic Pain in Rats with Spared Nerve Injury
Zhang, Haolin1; Sun, Jungang2; Xin, Xiyan1; Huo, Zejun1; Li, Dong1
通讯作者Zhang, Haolin(1) ; Li, Dong(1)
关键词Acupuncture Analgesia Neuropathic Pain Rats Spared Nerve Injury
刊名MEDICAL SCIENCE MONITOR
2018-05-08
DOI10.12659/MSM.909741
24页:2970-2974
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]HIPPOCAMPAL NEUROGENESIS ; ACUPOINT SPECIFICITY ; ACUPUNCTURE RESEARCH ; MODEL ; FMRI ; CONNECTIVITY ; STIMULATION ; ALLODYNIA ; TRIAL
英文摘要

Background: Acupuncture and electroacupuncture (EA) are widely applied in the treatment of various conditions, including pain. Acupuncture stimulation is applied not only in areas close to pain sites, but also in distal regions or on the contralateral side of the body. Identifying which acupuncture paradigms produce best therapeutic effects is of clinical significance.

Material/Methods: Spared nerve injury (SNI) was applied to establish a rat model of neuropathic pain. We applied 14 sessions of EA (BL 60 and BL 40, 1-2 mA, and 2 Hz, 30 min per session) every other day from days 3 to 29 after surgery on the contralateral or ipsilateral side of pain. von Frey hair was applied to examine mechanical allodynia in the SNI model and analgesic effects of EA. All experimental procedures were approved by the Animal Care and Use Committee of our university, according to the guidelines of the International Association for the Study of Pain.

Results: SNI produced significant and long-lasting mechanical allodynia (p<0.001) in injured paws. Repeated EA on the contralateral side of the pain significantly attenuated mechanical allodynia from 14 days after surgery (p<0.05). By contrast, ipsilateral EA did not show analgesic effects (p>0.05).

Conclusions: These findings indicate that contralateral EA is superior to local EA in some types of pain disorders. Further in-vestigations are needed for a more comprehensive understanding of the central mechanisms of acupuncture.

语种英语
WOS记录号WOS:000432257100010
通讯作者邮箱zhanghaolin@bjmu.edu.cn ; lidong6512@sina.com
第一作者单位Peking Univ, Hosp 3, Dept Tradit Chinese Med, Beijing, Peoples R China
通讯作者单位Peking Univ, Hosp 3, Dept Tradit Chinese Med, Beijing, Peoples R China
ISSN1643-3750
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/141865
专题北京大学第三临床医学院_中医科
北京大学第一临床医学院_病理科
作者单位1.Peking Univ, Hosp 3, Dept Tradit Chinese Med, Beijing, Peoples R China;
2.Sichuan Hosp Integrated Chinese & Western Med, Dept Internal Med, Chengdu, Sichuan, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Haolin,Sun, Jungang,Xin, Xiyan,et al. Contralateral Electroacupuncture Relieves Chronic Neuropathic Pain in Rats with Spared Nerve Injury[J]. MEDICAL SCIENCE MONITOR,2018,24:2970-2974.
APA Zhang, Haolin,Sun, Jungang,Xin, Xiyan,Huo, Zejun,&Li, Dong.(2018).Contralateral Electroacupuncture Relieves Chronic Neuropathic Pain in Rats with Spared Nerve Injury.MEDICAL SCIENCE MONITOR,24,2970-2974.
MLA Zhang, Haolin,et al."Contralateral Electroacupuncture Relieves Chronic Neuropathic Pain in Rats with Spared Nerve Injury".MEDICAL SCIENCE MONITOR 24(2018):2970-2974.
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