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学科主题临床医学
Kisspeptin/Kisspeptin Receptor System in the Ovary
Hu, Kai-Lun1; Zhao, Hongcui1; Chang, Hsun-Ming; Yu, Yang1; Qiao, Jie1
通讯作者Zhao, Hongcui(1) ; Yu, Yang(1)
关键词kisspeptin kisspeptin receptor ovarian function follicular development oocyte maturation ovulation steroidogenesis kisspeptin signaling
刊名FRONTIERS IN ENDOCRINOLOGY
2018-01-04
DOI10.3389/fendo.2017.00365
8
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]NF-KAPPA-B ; GONADOTROPIN-RELEASING-HORMONE ; METASTASIS-SUPPRESSOR GENE ; PROTEIN-COUPLED RECEPTOR ; FOLLICLE-STIMULATING-HORMONE ; MOS OLIGONUCLEOTIDES PREVENTS ; HUMAN CHORIONIC-GONADOTROPIN ; POSITIVE FEEDBACK ACTION ; PITUITARY-GONADAL AXIS ; IN-VITRO FERTILIZATION
英文摘要

Kisspeptins are a family of neuropeptides that are critical for initiating puberty and regulating ovulation in sexually mature females via the central control of the hypothalamic-pituitary-gonadal axis. Recent studies have shown that kisspeptin and its receptor kisspeptin receptor (KISS1R) are expressed in the mammalian ovary. Convincing evidence indicates that kisspeptins can activate a wide variety of signals via its binding to KISS1R. Experimental data gathered recently suggest a putative role of kisspeptin signaling in the direct control of ovarian function, including follicular development, oocyte maturation, steroidogenesis, and ovulation. Dysregulation or naturally occurring mutations of the kisspeptin/KISS1R system may negatively affect the ovarian function, leading to reproductive pathology or female infertility. A comprehensive understanding of the expression, actions, and underlying molecular mechanisms of this system in the human ovary is essential for novel approaches to therapeutic and diagnostic interventions in reproductive diseases and infertility.

语种英语
WOS记录号WOS:000419336700001
通讯作者邮箱rainbowandsun@163.com ; yuyang5012@hotmail.com
第一作者单位Peking Univ, Hosp 3, Minist Educ,Dept Obstet & Gynecol,Ctr Reprod Med, Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing, Peoples R China
通讯作者单位Peking Univ, Hosp 3, Minist Educ,Dept Obstet & Gynecol,Ctr Reprod Med, Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing, Peoples R China
ISSN1664-2392
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/141935
专题北京大学第三临床医学院_妇产科
北京大学第二临床医学院_麻醉科
北京大学第三临床医学院_生殖医学中心
作者单位1.Peking Univ, Hosp 3, Minist Educ,Dept Obstet & Gynecol,Ctr Reprod Med, Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing, Peoples R China;
2.Peking Univ, Hosp 3, Minist Educ,Dept Obstet & Gynecol, Key Lab Assisted Reprod,Ctr Reprod Med, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Hu, Kai-Lun,Zhao, Hongcui,Chang, Hsun-Ming,et al. Kisspeptin/Kisspeptin Receptor System in the Ovary[J]. FRONTIERS IN ENDOCRINOLOGY,2018,8.
APA Hu, Kai-Lun,Zhao, Hongcui,Chang, Hsun-Ming,Yu, Yang,&Qiao, Jie.(2018).Kisspeptin/Kisspeptin Receptor System in the Ovary.FRONTIERS IN ENDOCRINOLOGY,8.
MLA Hu, Kai-Lun,et al."Kisspeptin/Kisspeptin Receptor System in the Ovary".FRONTIERS IN ENDOCRINOLOGY 8(2018).
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