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学科主题临床医学
Human trophoblast cell during first trimester after IVF-ET differs from natural conceived pregnancy in development and function
Yang, Rui1,2; Liu, Ying-ying1,2; Zhao, Liang1,2; Wang, Ying1,2; Li, Rong1,2; Liu, Ping1,2; Ma, Cai-hong1,2; Chen, Xin-na1,2; Qiao, Jie1,2
通讯作者Wang, Ying()
关键词Cytotrophoblast cell Syncytiotrophoblast cell In vitro fertilization and embryo transfer Natural pregnancy Proteomic analysis
刊名HISTOLOGY AND HISTOPATHOLOGY
2017-03-01
DOI10.14670/HH-11-787
32期:3页:243-251
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Pathology
研究领域[WOS]Cell Biology ; Pathology
关键词[WOS]IN-VITRO-FERTILIZATION ; PROTEOMIC ANALYSIS ; ALPHA-FETOPROTEIN ; OXIDATIVE STRESS ; HUMAN PLACENTA ; APOPTOSIS
英文摘要

Objective. To explore the differences of the trophoblast cell function in first trimester between natural pregnancy and pregnancy after IVF-ET therapy.

Methods. 102 cases with twin to singleton fetal reduction after IVF-ET treatment from July 2010 to August 2013 in Peking University Third Hospital were involved in analysis, and eight specimens were obtained from this group. 10 natural-pregnancy cases undergoing artificial abortion with unwanted pregnancy were recruited as control. Semi-quantitative immunohistochemical method was used to detect the expression of EGFR, Bcl-2, tubulin-alpha, metallothionein and AFP in villi in both groups.

Results. Of the 102 cases, 14 cases (13.73%) were aborted. Preterm birth occurred in seven cases (7.86%). Low birth weight occurred in three patients (3.37%), and extremely low birth weight occurred in four cases (4.49%). The expression of EGFR, tubulin-alpha, Bcl-2, and metallothionein in the IVF-ET group was significantly lower than that in the control group (P<0.05). However, AFP expression was significantly higher in IVF-ET group than in control group (P<0.05). In IVF-ET group, the miscarriage case had weaker EGFR, tubulin-alpha, and metallothionein expression than full-term pregnancy; the early preterm labor case had weaker Bcl-2, tubulin-alpha, and metallothionein expression; and velamentous cord insertion case had weaker tubulin-alpha expression.

Conclusions. The trophoblast cell function of IVF-ET group in first trimester is different from control group in proliferation, invasion, apoptosis and vascular development, and optimal pregnancy outcome depends on the self-healing balance of trophoblast cells.

语种英语
WOS记录号WOS:000390220000004
通讯作者邮箱wangying02114@bjmu.edu.cn
第一作者单位Peking Univ, Reprod Med Ctr, Dept Obstet & Gynecol, Hosp 3,Key Lab Assisted Reprod,Minist Educ, Beijing, Peoples R China ; Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing, Peoples R China
ISSN0213-3911
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/141946
专题北京大学第三临床医学院_妇产科
北京大学第三临床医学院_经营管理办公室
北京大学临床肿瘤学院_药剂科
北京大学第三临床医学院_生殖医学中心
作者单位1.Peking Univ, Reprod Med Ctr, Dept Obstet & Gynecol, Hosp 3,Key Lab Assisted Reprod,Minist Educ, Beijing, Peoples R China;
2.Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Yang, Rui,Liu, Ying-ying,Zhao, Liang,et al. Human trophoblast cell during first trimester after IVF-ET differs from natural conceived pregnancy in development and function[J]. HISTOLOGY AND HISTOPATHOLOGY,2017,32(3):243-251.
APA Yang, Rui.,Liu, Ying-ying.,Zhao, Liang.,Wang, Ying.,Li, Rong.,...&Qiao, Jie.(2017).Human trophoblast cell during first trimester after IVF-ET differs from natural conceived pregnancy in development and function.HISTOLOGY AND HISTOPATHOLOGY,32(3),243-251.
MLA Yang, Rui,et al."Human trophoblast cell during first trimester after IVF-ET differs from natural conceived pregnancy in development and function".HISTOLOGY AND HISTOPATHOLOGY 32.3(2017):243-251.
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