学科主题药学
New saikosaponins from the roots of Bupleurum chinense
Wang, Yanyan1,2; Guo, Qiang1,2; Cheng, Zhongbin1,2; Zeng, Kewu1,2; Liang, Hong1,2; Tu, Pengfei1,2; Chen, Shizhong1,2; Zhang, Qingying1,2
通讯作者Zhang, Qingying(2)
关键词Bupleuri Radix Bupleurum chinense Saikosaponins Anti-inflammatory activity
刊名PHYTOCHEMISTRY LETTERS
2017-09-01
DOI10.1016/j.phytol.2017.06.005
21页:183-189
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]INFLAMMATION ; GLYCOSIDES ; RATS
英文摘要

Seven new saikosaponins (1-7), together with four known ones (8 - 11), were isolated from the roots of Bupleurum chinense. Their structures were elucidated by comprehensive spectroscopic analysis and chemical methods. All obtained saikosaponins were oleanane-type, except for compound 11, which was the first lupane-type saikosaponin isolated from the genus Bupleurum. Compound 1 represented the first example of saikosaponins bearing a hydroxyl group at C-15, while compound 4 was a saikosaponin containing acetoxy group at C-23 rarely found in genus Bupleurum. Compounds 6 and 7, bearing an n-butoxy moiety at C-11, were confirmed to be artifacts by LC-MS experiment. All the isolates were evaluated for their inhibitory effects towards nitric oxide production induced by lipopolysaccharide in BV-2 microglial cells, and saikosaponins A (9) and D (10) exhibited the most potent activity, which were comparable to the positive control dexamethasone.

语种英语
WOS记录号WOS:000414229300036
通讯作者邮箱qyzhang@hsc.pku.edu.cn
第一作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Hlth Sci Ctr, 38 Xueyuan Rd, Beijing 100191, Peoples R China
通讯作者单位Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, Hlth Sci Ctr, 38 Xueyuan Rd, Beijing 100191, Peoples R China
ISSN1874-3900
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/141952
专题北京大学药学院_天然药物与仿生药物国家重点实验室
北京大学药学院_天然药物学系
北京大学药学院_生药研究室
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Hlth Sci Ctr, 38 Xueyuan Rd, Beijing 100191, Peoples R China;
2.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, Hlth Sci Ctr, 38 Xueyuan Rd, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wang, Yanyan,Guo, Qiang,Cheng, Zhongbin,et al. New saikosaponins from the roots of Bupleurum chinense[J]. PHYTOCHEMISTRY LETTERS,2017,21:183-189.
APA Wang, Yanyan.,Guo, Qiang.,Cheng, Zhongbin.,Zeng, Kewu.,Liang, Hong.,...&Zhang, Qingying.(2017).New saikosaponins from the roots of Bupleurum chinense.PHYTOCHEMISTRY LETTERS,21,183-189.
MLA Wang, Yanyan,et al."New saikosaponins from the roots of Bupleurum chinense".PHYTOCHEMISTRY LETTERS 21(2017):183-189.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Yanyan]的文章
[Guo, Qiang]的文章
[Cheng, Zhongbin]的文章
百度学术
百度学术中相似的文章
[Wang, Yanyan]的文章
[Guo, Qiang]的文章
[Cheng, Zhongbin]的文章
必应学术
必应学术中相似的文章
[Wang, Yanyan]的文章
[Guo, Qiang]的文章
[Cheng, Zhongbin]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。