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Fine particle matter disrupts the blood-testis barrier by activating TGF-beta 3/p38 MAPK pathway and decreasing testosterone secretion in rat
Liu, Jianhui1,2; Ren, Lihua1,3; Wei, Jialiu1,2; Zhang, Jin1,2; Zhu, Yupeng1,2; Li, Xiangyang1,2; Jing, Li1,2; Duan, Junchao1,2; Zhou, Xianqing1,2; Sun, Zhiwei1,2
通讯作者Zhou, Xianqing(1,2)
关键词androgenic hormones blood-testis barrier fine particulate matter male reproductive toxicity rat TGF-beta 3/p38MAPK pathway
刊名ENVIRONMENTAL TOXICOLOGY
2018-07-01
DOI10.1002/tox.22556
33期:7页:711-719
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Environmental Sciences ; Toxicology ; Water Resources
研究领域[WOS]Environmental Sciences & Ecology ; Toxicology ; Water Resources
关键词[WOS]NECROSIS-FACTOR-ALPHA ; PARTICULATE MATTER ; SERTOLI-CELL ; SEMINIFEROUS EPITHELIUM ; AIR-POLLUTION ; IN-VIVO ; CARDIOVASCULAR-DISEASE ; SIGNALING PATHWAYS ; ANDROGEN RECEPTOR ; INTERFERON-GAMMA
英文摘要

Fine particle matter (PM) is correlated with male reproductive dysfunction in animals and humans, but the underlying mechanisms remain unknown. To investigate the toxic mechanism of PM, 32 male Sprague-Dawley (SD) rats were exposed to saline or PM2.5 with the doses of 1.8, 5.4, and 16.2 mg/kg.b.w. via intratracheal instillation, respectively, one time every 3 days, in total times for 30 days. Sperm concentration, hormone level, the expressions of BTB-associated protein and the mitogen-activated protein kinase (MAPK) pathway, tumor necrosis factor and transforming growth factor 3 levels were detected. The results showed a decrease in sperm number, testosterone and luteinizing hormone levels and altered ultrastructure of BTB in testis of rat after exposure to PM2.5. The protein levels of N-Cadherin, Occludin, Claudin-11, and Connexin-43 were significantly decreased in the testes. TGF-3 content in testes showed increase, with the p-p38/p38 MAPK ratio also increasing after PM2.5 exposure. These results demonstrate that PM2.5 restrained the expressions of BTB-associated proteins through activating TGF-3/p38 MAPK pathway and decreasing testosterone secretion, and therefore lead to the damage of BTB resulting in the decrease of sperm quality, which might be the potential reasons for its negative effects on spermatogenesis and male reproduction.

语种英语
WOS记录号WOS:000436799900001
通讯作者邮箱xqzhou2@163.com
ISSN1520-4081
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/141971
专题北京大学护理学院
北京大学口腔医学院_材料检测中心
作者单位1.Peking Univ, Sch Nursing, Beijing 100191, Peoples R China;
2.Capital Med Univ, Sch Publ Hlth, Dept Toxicol & Hygien Chem, Beijing 100069, Peoples R China;
3.Capital Med Univ, Beijing Key Lab Environm Toxicol, Beijing 100069, Peoples R China
推荐引用方式
GB/T 7714
Liu, Jianhui,Ren, Lihua,Wei, Jialiu,et al. Fine particle matter disrupts the blood-testis barrier by activating TGF-beta 3/p38 MAPK pathway and decreasing testosterone secretion in rat[J]. ENVIRONMENTAL TOXICOLOGY,2018,33(7):711-719.
APA Liu, Jianhui.,Ren, Lihua.,Wei, Jialiu.,Zhang, Jin.,Zhu, Yupeng.,...&Sun, Zhiwei.(2018).Fine particle matter disrupts the blood-testis barrier by activating TGF-beta 3/p38 MAPK pathway and decreasing testosterone secretion in rat.ENVIRONMENTAL TOXICOLOGY,33(7),711-719.
MLA Liu, Jianhui,et al."Fine particle matter disrupts the blood-testis barrier by activating TGF-beta 3/p38 MAPK pathway and decreasing testosterone secretion in rat".ENVIRONMENTAL TOXICOLOGY 33.7(2018):711-719.
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