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学科主题基础医学
Lung squamous cell carcinoma cells express non-canonically glycosylated IgG that activates integrin-FAK signaling
Tang, Jingshu1,2; Zhang, Jingxuan1,2; Liu, Yang1,2; Liao, Qinyuan1,2; Huang, Jing1,2; Geng, Zihan1,2; Xu, Weiyan1,2; Sheng, Zhengzuo3; Lee, Gregory4; Zhang, Youhui5; Chen, Jinfeng6; Zhang, Liang7,8; Qiu, Xiaoyan1,2
通讯作者Zhang, Liang(7,8) ; Qiu, Xiaoyan(1,2)
关键词Cancer IgG LSCC Integrin FAK signaling
刊名CANCER LETTERS
2018
DOI10.1016/j.canlet.2018.05.024
430页:148-159
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]FOCAL ADHESION KINASE ; PAN CANCER MARKER ; ALPHA-6-BETA-4 INTEGRIN ; BLADDER-CANCER ; MONOCLONAL-ANTIBODY ; IMMUNOGLOBULIN-G ; GENE-EXPRESSION ; BREAST-CANCER ; ANTIGEN EXPRESSION ; STEM-CELL
英文摘要

It is increasingly recognized that many human carcinomas express immunoglobulin (Ig) molecules that are distinct from B-cell-derived Ig and play important roles in cancer initiation, progression, and metastasis. However, the molecular mechanisms underlying the functions of cancer-derived Ig remain elusive. Here, we report that lung squamous cell carcinoma (LSCC) cells frequently express high levels of cancer IgG (CIgG) that is specifically recognized by a monoclonal antibody RP215. RP215 recognizes CIgG via a novel epitope that involves an N-glycan modification at a non-consensus site within the C(H)1 domain. We demonstrate that RP215 recognized CIgG (RP215-CIgG) promotes survival, migration and in vivo growth of LSCC cells, and these oncogenic activities are strongly inhibited by RP215. Mechanistically, RP215-CIgG executes its oncogenic function through interacting with the integrin alpha 6 beta 4 complex and activating the FAK and Src pathways. Notably, the CIgG-integrin-FAK signaling depends on the N-glycan epitope, which is inhibited by RP215. Together, our studies identified a novel CIgG molecule that activates the oncogenic integrin-FAK signaling in LSCC cells. In addition, the activity of CIgG is inhibited by RP215, providing an attractive target for antibody-based therapy of ISCC.

语种英语
WOS记录号WOS:000436912200014
通讯作者邮箱liangzhang.28@cityu.edu.hk ; qiuxy@bjmu.edu.cn
第一作者单位Peking Univ, Sch Basic Med Sci, Dept Immunol, Beijing 100191, Peoples R China ; Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China
通讯作者单位Peking Univ, Sch Basic Med Sci, Dept Immunol, Beijing 100191, Peoples R China ; Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China ; City Univ Hong Kong, Coll Vet Med & Life Sci, Dept Biomed Sci, Hong Kong 999077, Hong Kong, Peoples R China ; City Univ Hong Kong, Shenzhen Res Inst, Shenzhen 518057, Guangdong, Peoples R China
ISSN0304-3835
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/142178
专题北京大学基础医学院_免疫学系
北京大学基础医学院
北京大学临床肿瘤学院_胸部肿瘤外二科
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Immunol, Beijing 100191, Peoples R China;
2.Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China;
3.Peking Univ, Peoples Hosp, Dept Urol, Clin Med Coll 2, Beijing 100044, Peoples R China;
4.Univ British Columbia, Androl Lab, Ctr Reprod Hlth, Vancouver, BC V5Z 4H4, Canada;
5.Chinese Acad Med Sci, Canc Inst & Hosp, Dept Immunol, Beijing 100021, Peoples R China;
6.Peking Univ Canc Hosp & Inst, Dept Thorac Surg 2, Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China;
7.City Univ Hong Kong, Coll Vet Med & Life Sci, Dept Biomed Sci, Hong Kong 999077, Hong Kong, Peoples R China;
8.City Univ Hong Kong, Shenzhen Res Inst, Shenzhen 518057, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Tang, Jingshu,Zhang, Jingxuan,Liu, Yang,et al. Lung squamous cell carcinoma cells express non-canonically glycosylated IgG that activates integrin-FAK signaling[J]. CANCER LETTERS,2018,430:148-159.
APA Tang, Jingshu.,Zhang, Jingxuan.,Liu, Yang.,Liao, Qinyuan.,Huang, Jing.,...&Qiu, Xiaoyan.(2018).Lung squamous cell carcinoma cells express non-canonically glycosylated IgG that activates integrin-FAK signaling.CANCER LETTERS,430,148-159.
MLA Tang, Jingshu,et al."Lung squamous cell carcinoma cells express non-canonically glycosylated IgG that activates integrin-FAK signaling".CANCER LETTERS 430(2018):148-159.
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