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Cytotoxic carbazole alkaloid derivatives from the leaves and stems of Murraya microphylla
Ma, Xiaoli; Cao, Nankai; Zhang, Chen; Guo, Xiaoyu; Zhao, Mingbo; Tu, Pengfei; Jiang, Yong
通讯作者Jiang, Yong(1)
关键词Murraya microphylla Carbazole alkaloid ECD exciton coupling method Cytotoxicity
刊名FITOTERAPIA
2018-06-01
DOI10.1016/j.fitote.2018.03.010
127页:334-340
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]CLAUSENA-LANSIUM ; NATURAL-PRODUCTS ; KOENIGII ; TETRAMERA
英文摘要

Four new carbazole alkaloid derivatives, including a pair of enantiomers of the heterodimers of carbazole and phenylpropanoid (1a/1b) and two rare polyprenylated carbazole alkaloids (2, 3), together with 19 known analogues (4-22), were isolated from the leaves and stems of Murraya microphylla. Their structures were established by UV, IR, 1D/2D NMR, and HRESIMS data analysis, and their absolute configurations were determined by comparison of experimental and calculated ECD data and the ECD exciton coupling method. All the isolates were evaluated for their cytotoxicities against HepG2, Du145, HCT-116, and HeLa tumor cell lines. Compounds 7 and 11 exhibited obvious cytotoxic effects on four cancer cell lines in a dose-dependent manner.

语种英语
WOS记录号WOS:000437551000049
通讯作者邮箱yongjiang@bjmu.edu.cn
第一作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
通讯作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
ISSN0367-326X
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/142193
专题北京大学药学院
北京大学药学院_天然药物学系
北京大学临床肿瘤学院_淋巴肿瘤内科
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
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GB/T 7714
Ma, Xiaoli,Cao, Nankai,Zhang, Chen,et al. Cytotoxic carbazole alkaloid derivatives from the leaves and stems of Murraya microphylla[J]. FITOTERAPIA,2018,127:334-340.
APA Ma, Xiaoli.,Cao, Nankai.,Zhang, Chen.,Guo, Xiaoyu.,Zhao, Mingbo.,...&Jiang, Yong.(2018).Cytotoxic carbazole alkaloid derivatives from the leaves and stems of Murraya microphylla.FITOTERAPIA,127,334-340.
MLA Ma, Xiaoli,et al."Cytotoxic carbazole alkaloid derivatives from the leaves and stems of Murraya microphylla".FITOTERAPIA 127(2018):334-340.
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