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Integration of Metabolomics With Pharmacodynamics to Elucidate the Anti-myocardial lschemia Effects of Combination of Notoginseng Total Saponins and Safflower Total Flavonoids
Meng, Yuqing1; Du, Zhiyong1; Li, Yan1; Wang, Lichao1; Gao, Peng1; Gao, Xiaoyan2; Li, Chun3; Zhao, Mingbo1; Jiang, Yong1; Tu, Pengfei1; Guo, Xiaoyu1
通讯作者Guo, Xiaoyu(1)
关键词metabolomics myocardial ischemia cardioprotective effects UPLC-Q-TOF/MS notoginseng total saponins safflower total flavonoids
刊名FRONTIERS IN PHARMACOLOGY
2018-06-25
DOI10.3389/fphar.2018.00667
9
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]CORONARY-ARTERY-DISEASE ; SERUM URIC-ACID ; PALMITOYL-L-CARNITINE ; NF-KAPPA-B ; CARTHAMUS-TINCTORIUS ; PANAX-NOTOGINSENG ; SARCOPLASMIC-RETICULUM ; PLASMA-ALDOSTERONE ; RAT CARDIOMYOCYTES ; LIPIDOMIC ANALYSIS
英文摘要

Notoginseng (Sanqi), the roots and rhizomes of Panax notoginseng and safflower, the flowers of Carthamus tinctorius, are widely used traditional Chinese medicines (TCMs) for the treatment of cardiovascular diseases. Positive evidences have fueled growing acceptance for cardioprotective effects of the combination of the notoginseng total saponins and safflower total flavonoids (CNS) against myocardial ischemia (MI). However, the underlying cardioprotective mechanisms of CNS are still obscured. Metabolomics is a comprehensive tool for investigating biological mechanisms of disease, monitoring therapeutic outcomes, and advancing drug discovery and development. Herein, we investigated the cardioprotective effects of CNS on the isoproterenol (ISO)-induced MI rats by using plasma and urine metabolomics based on ultra-performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry (UPLC-Q-TOF/MS) and multiple pharmacodynamics approaches. The results showed that pretreatment with CNS could attenuate the cardiac injury resulting from ISO, as evidenced by decreasing the myocardial infarct size, converting the echocardiographic, histopathological, and plasma biochemical abnormalities, and reversing the perturbations of plasma and urine metabolic profiles, particularly for the 55.0 mg/kg dosage group. In addition, 44 metabolites were identified as the potential MI biomarkers, mainly including a range of free fatty acids (FFAs), sphingolipids, and glycerophospholipids. CNS pretreatment group may robustly ameliorate these potential MI-related biomarkers. The accumulation of LysoPCs and FFAs, caused by PLA(2), may activate NF-kappa B pathway and increase proinflammatory cytokines. However, our results showed that CNS at 55.0 mg/kg dosage could maximally attenuate the NF-kappa B signaling pathway, depress the expressions of TNIF-alpha, IL-6, IL-1 beta, and PLA(2). The results suggested that the anti-inflammatory property of CNS may contribute to its cardioprotection against MI. Our results demonstrate that the integrating of metabolomics with pharmacodynamics provides a reasonable approach for understanding the therapeutic effects of TCMs and CNS provide a potential candidate for prevention and treatment of MI.

语种英语
WOS记录号WOS:000436118200001
通讯作者邮箱guoxiaoyu@bjmu.edu.cn
第一作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China
通讯作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China
ISSN1663-9812
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/142195
专题北京大学药学院
北京大学药学院_天然药物学系
北京大学临床肿瘤学院_后勤处
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China;
2.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing, Peoples R China;
3.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Meng, Yuqing,Du, Zhiyong,Li, Yan,et al. Integration of Metabolomics With Pharmacodynamics to Elucidate the Anti-myocardial lschemia Effects of Combination of Notoginseng Total Saponins and Safflower Total Flavonoids[J]. FRONTIERS IN PHARMACOLOGY,2018,9.
APA Meng, Yuqing.,Du, Zhiyong.,Li, Yan.,Wang, Lichao.,Gao, Peng.,...&Guo, Xiaoyu.(2018).Integration of Metabolomics With Pharmacodynamics to Elucidate the Anti-myocardial lschemia Effects of Combination of Notoginseng Total Saponins and Safflower Total Flavonoids.FRONTIERS IN PHARMACOLOGY,9.
MLA Meng, Yuqing,et al."Integration of Metabolomics With Pharmacodynamics to Elucidate the Anti-myocardial lschemia Effects of Combination of Notoginseng Total Saponins and Safflower Total Flavonoids".FRONTIERS IN PHARMACOLOGY 9(2018).
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