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Evidence of interaction between genes in the folate/homocysteine metabolic pathway in controlling risk of non-syndromic oral cleft
Wang, P.1,2,3; Wu, T.1,4; Schwender, H.5; Wang, H.1; Shi, B.6; Wang, Z. Q.1; Yuan, Y.1; Liu, D. J.1; Wang, M. Y.1; Li, J.7; Zhou, Z. B.8; Zhu, H. P.8; Beaty, T. H.9
通讯作者Wu, T.(1,4)
关键词folate homocysteine metabolic pathway gene-gene interaction non-syndromic oral cleft
刊名ORAL DISEASES
2018-07-01
DOI10.1111/odi.12831
24期:5页:820-828
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]GENOME-WIDE ASSOCIATION ; CYSTATHIONINE BETA-SYNTHASE ; CASE-PARENT TRIO ; OROFACIAL CLEFTS ; CHINESE POPULATION ; FOLIC-ACID ; SUSCEPTIBILITY LOCUS ; MTHFR POLYMORPHISMS ; FOLATE PATHWAY ; BHMT2 GENES
英文摘要

ObjectiveLittle consistent evidence is available for the association between the risk of non-syndromic cleft lip with or without cleft palate (NSCL/P) and any of the individual genes in the folate/homocysteine metabolic pathway. We investigated the genes in the folate pathway to further clarify its potential influence on the risk of NSCL/P considering gene-gene (GxG) interaction.

Subjects and methodsWe selected markers in 18 genes from the pathway and applied Cordell′s method to test for GxG interaction using 1,908 NSCL/P case-parent trios ascertained in an international consortium where a genomewide association study (GWAS) of oral clefts was conducted.

ResultsWe found intriguing signals among Asian and European ancestry groups for GxG interaction between markers in betaine-homocysteine methyltransferase gene (BHMT/BHMT2) and dimethylglycine dehydrogenase gene (DMGDH) attaining genomewide significance. In the pooled data, the top significant interaction was found between rs13158309 (BHMT) and rs10514154 (DMGDH, p=1.45x10(-12)).

ConclusionsOur study illustrated the importance of taking into account potential GxG interaction for genetic association analysis in NSCL/P, and this study suggested both BHMT/BHMT2 and DMGDH should be considered as candidate genes for NSCL/P in future studies.

语种英语
WOS记录号WOS:000435803800018
通讯作者邮箱twu@bjmu.edu.cn
第一作者单位Peking Univ, Sch Publ Hlth, Beijing, Peoples R China ; Beijing Ctr Dis Prevent & Control, Dept Stat & Informat, Beijing, Peoples R China ; Beijing Res Ctr Prevent Med, Beijing, Peoples R China
通讯作者单位Peking Univ, Sch Publ Hlth, Beijing, Peoples R China ; Minist Hlth, Key Lab Reprod Hlth, Beijing, Peoples R China
ISSN1354-523X
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/142201
专题北京大学公共卫生学院
北京大学临床肿瘤学院_病理科
作者单位1.Peking Univ, Sch Publ Hlth, Beijing, Peoples R China;
2.Beijing Ctr Dis Prevent & Control, Dept Stat & Informat, Beijing, Peoples R China;
3.Beijing Res Ctr Prevent Med, Beijing, Peoples R China;
4.Minist Hlth, Key Lab Reprod Hlth, Beijing, Peoples R China;
5.Heinrich Heine Univ Duesseldorf, Math Inst, Dusseldorf, Germany;
6.Sichuan Univ, West China Sch Stomatol, State Key Lab Oral Dis, Chengdu, Sichuan, Peoples R China;
7.Peking Univ, Sch Stomatol, Pediat Dent, Beijing, Peoples R China;
8.Peking Univ, Sch Stomatol, Oral & Maxillofacial Surg, Beijing, Peoples R China;
9.Johns Hopkins Univ, Sch Publ Hlth, Baltimore, MD USA
推荐引用方式
GB/T 7714
Wang, P.,Wu, T.,Schwender, H.,et al. Evidence of interaction between genes in the folate/homocysteine metabolic pathway in controlling risk of non-syndromic oral cleft[J]. ORAL DISEASES,2018,24(5):820-828.
APA Wang, P..,Wu, T..,Schwender, H..,Wang, H..,Shi, B..,...&Beaty, T. H..(2018).Evidence of interaction between genes in the folate/homocysteine metabolic pathway in controlling risk of non-syndromic oral cleft.ORAL DISEASES,24(5),820-828.
MLA Wang, P.,et al."Evidence of interaction between genes in the folate/homocysteine metabolic pathway in controlling risk of non-syndromic oral cleft".ORAL DISEASES 24.5(2018):820-828.
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