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Opposite Genetic Effects of CMIP Polymorphisms on the Risk of Type 2 Diabetes and Obesity: A Family-Based Study in China
Cao, Yaying1; Wang, Tao2; Wu, Yiqun1; Juan, Juan1; Qin, Xueying1; Tang, Xun1; Wu, Tao1; Hu, Yonghua1
通讯作者Hu, Yonghua(1)
关键词pleiotropic genetic effects CMIP type 2 diabetes mellitus obesity sex-specific pattern family-based study
刊名INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2018-04-01
DOI10.3390/ijms19041011
19期:4
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]GENOME-WIDE ASSOCIATION ; QUANTITATIVE TRAIT LOCI ; WAIST-HIP RATIO ; GENDER-DIFFERENCES ; SUSCEPTIBILITY LOCI ; SEXUAL-DIMORPHISM ; FAT DISTRIBUTION ; TUNISIAN ARABS ; MELLITUS ; METAANALYSIS
英文摘要

C-Maf Inducing Protein (CMIP) gene polymorphisms were reported to be associated with type 2 diabetes mellitus (T2DM). Whether the association between CMIP and T2DM is mediated via obesity-related phenotypes is still unclear. We analyzed the association of CMIP rs2925979 with T2DM and a comprehensive set of obesity-related phenotypes in 1576 families ascertained from a Chinese population. These families included a total of 3444 siblings (1582 with T2DM, 963 with prediabetes, and 899 with a normal glucose level). Using multi-level mixed effects regression models, we found that each copy of CMIP rs2925979_T allele was associated with a 29% higher risk of T2DM in females (p = 9.30 x 10(-4)), while it was not significantly associated with T2DM in males (p = 0.705). Meanwhile, rs2925979_T allele was associated with lower levels of body mass index (BMI), waist circumference (WC), hip circumference (HC), percentage of body fat (PBF), PBF of arms, PBF of legs, and PBF of trunk in nondiabetes females (all p < 0.05). The opposite associations of rs2925979_T allele with T2DM and obesity-related phenotypes suggest that CMIP may exert independent pleiotropic effects on T2DM and obesity-related phenotypes in females.

语种英语
WOS记录号WOS:000434978700090
通讯作者邮箱yhhu@bjmu.edu.cn
第一作者单位Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
通讯作者单位Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
ISSN1422-0067
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/142203
专题北京大学公共卫生学院
北京大学医学部管理机构_医学部
北京大学公共卫生学院_流行病与卫生统计学系
北京大学公共卫生学院_公共卫生学院
北京大学临床肿瘤学院_麻醉科
作者单位1.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China;
2.Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10461 USA
推荐引用方式
GB/T 7714
Cao, Yaying,Wang, Tao,Wu, Yiqun,et al. Opposite Genetic Effects of CMIP Polymorphisms on the Risk of Type 2 Diabetes and Obesity: A Family-Based Study in China[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2018,19(4).
APA Cao, Yaying.,Wang, Tao.,Wu, Yiqun.,Juan, Juan.,Qin, Xueying.,...&Hu, Yonghua.(2018).Opposite Genetic Effects of CMIP Polymorphisms on the Risk of Type 2 Diabetes and Obesity: A Family-Based Study in China.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,19(4).
MLA Cao, Yaying,et al."Opposite Genetic Effects of CMIP Polymorphisms on the Risk of Type 2 Diabetes and Obesity: A Family-Based Study in China".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 19.4(2018).
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