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学科主题临床医学
mi R-199b-5p serves as a tumor suppressor in renal cell carcinoma
Lai, Yulin1,2; Quan, Jing1,3; Hu, Jia1,2; Chen, Peijie1,4; Xu, Jinling1,5; Guan, Xin1,5; Xu, Weijie1,5; Lai, Yongqing1,5; Ni, Liangchao1,5
通讯作者Ni, Liangchao(1,5)
关键词microRNA microRNA-199b-5p tumor suppressor renal cell carcinoma
刊名EXPERIMENTAL AND THERAPEUTIC MEDICINE
2018-07-01
DOI10.3892/etm.2018.6151
16期:1页:436-444
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]DOWN-REGULATION ; POOR-PROGNOSIS ; CANCER CELLS ; MICRORNA-199B-5P ; PROLIFERATION ; EXPRESSION ; MICRORNAS ; PATHWAY ; OSTEOSARCOMA ; INVASION
英文摘要

MicroRNA (miR)-199b-5p has been reported to have a critical role in various types of malignancy. However, the exact function miR-199b-5p in renal cancer remains to be fully elucidated. The present study aimed to detect the expression levels of miR-199b-5p in renal cell carcinoma (RCC) tissues and RCC cell lines, and investigated the effect of miR-199b-5p in vitro with Cell Counting Kit-8, MTT, scratch wound, Transwell and flow cytometric assays. The results demonstrated that the expression levels of miR-199b-5p were significantly downregulated in RCC tissues and cell lines compared with those in paired adjacent normal renal tissues and a reference cell line, respectively. Downregulation of miR-199b-5p by transfection with a synthetic inhibitor promoted cellular proliferation and migration, while reducing the apoptotic rate, indicating that miR-199b-5p may serve as a tumor suppressor in RCC. Further study is required to identify target genes of miR-199b-5p to elucidate the mechanisms underlying the role of miR-199b-5p in the occurrence and development of RCC.

语种英语
WOS记录号WOS:000437115500062
通讯作者邮箱lncord@163.com
第一作者单位Peking Univ, Shenzhen Hosp, Dept Urol, 1120 Lianhua Rd, Shenzhen 518036, Guangdong, Peoples R China ; Guangzhou Med Univ, Grad Sch, Guangzhou 511436, Guangdong, Peoples R China
通讯作者单位Peking Univ, Shenzhen Hosp, Dept Urol, 1120 Lianhua Rd, Shenzhen 518036, Guangdong, Peoples R China ; Peking Univ, Shenzhen Hosp, Inst Urol, Shenzhen PKU HKUST Med Ctr,Guangdong & Shenzhen K, Shenzhen 518036, Guangdong, Peoples R China
ISSN1792-0981
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/142218
专题北京大学深圳医院_泌尿外科
北京大学第三临床医学院_皮肤科
北京大学口腔医学院_儿童口腔科
作者单位1.Peking Univ, Shenzhen Hosp, Dept Urol, 1120 Lianhua Rd, Shenzhen 518036, Guangdong, Peoples R China;
2.Guangzhou Med Univ, Grad Sch, Guangzhou 511436, Guangdong, Peoples R China;
3.Anhui Med Univ, Grad Sch, Hefei 230032, Anhui, Peoples R China;
4.Shantou Univ, Coll Med, Grad Sch, Shantou 515041, Guangdong, Peoples R China;
5.Peking Univ, Shenzhen Hosp, Inst Urol, Shenzhen PKU HKUST Med Ctr,Guangdong & Shenzhen K, Shenzhen 518036, Guangdong, Peoples R China
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GB/T 7714
Lai, Yulin,Quan, Jing,Hu, Jia,et al. mi R-199b-5p serves as a tumor suppressor in renal cell carcinoma[J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE,2018,16(1):436-444.
APA Lai, Yulin.,Quan, Jing.,Hu, Jia.,Chen, Peijie.,Xu, Jinling.,...&Ni, Liangchao.(2018).mi R-199b-5p serves as a tumor suppressor in renal cell carcinoma.EXPERIMENTAL AND THERAPEUTIC MEDICINE,16(1),436-444.
MLA Lai, Yulin,et al."mi R-199b-5p serves as a tumor suppressor in renal cell carcinoma".EXPERIMENTAL AND THERAPEUTIC MEDICINE 16.1(2018):436-444.
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