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学科主题临床医学
Isoflurane-induced postoperative cognitive dysfunction is mediated by hypoxia-inducible factor-1-dependent neuroinflammation in aged rats
Cao, Yiyun1,2; Li, Zhengqian2; Ma, Lijun3; Ni, Cheng2; Li, Lunxu2; Yang, Ning2; Shi, Chengmei2; Guo, Xiangyang2
通讯作者Guo, Xiangyang(2)
关键词isoflurane postoperative cognitive dysfunction hypoxia-inducible factor-1 nuclear factor-B
刊名MOLECULAR MEDICINE REPORTS
2018-06-01
DOI10.3892/mmr.2018.8850
17期:6页:7730-7736
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Medicine, Research & Experimental
研究领域[WOS]Oncology ; Research & Experimental Medicine
关键词[WOS]FACTOR-KAPPA-B ; BLOOD-BRAIN-BARRIER ; SIGNALING PATHWAY ; UP-REGULATION ; IN-VITRO ; HIF-1-ALPHA ; INFLAMMATION ; CELLS ; HYPOXIA-INDUCIBLE-FACTOR-1-ALPHA ; ACTIVATION
英文摘要

Elderly patients are at high risk of developing postoperative cognitive dysfunction (POCD) after prolonged exposure to inhaled anesthetics. However, the pathogenesis of POCD remains unknown. Hypoxia-inducible factor-1 (HIF-1) is activated by inhaled anesthetics. The aim of the present study was to determine the role of HIF-1 in isoflurane-induced neuroinflammation and the resulting cognitive impairment. Following a 4-h exposure to 1.5% isoflurane in 20-month-old rats, increased expression of HIF-1 protein, activation of nuclear factor (NF)-B signaling and increased expression of TNF-1 were observed in the hippocampus of isoflurane-exposed rats compared with the control group. Pharmacological inhibition of HIF-1 activation by 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol (YC-1) markedly suppressed the enhanced expression of HIF-1, disrupted NF-B signaling pathway activity and inhibited the isoflurane-induced increase of TNF-1 expression. YC-1 pretreatment also significantly attenuated isoflurane-induced cognitive deficits according to the results of the Morris water maze task. These results suggest that hippocampal HIF-1 appears to be involved in an upstream mechanism of isoflurane-induced cognitive impairment. Further research is warranted to fully clarify the pathogenesis and investigate HIF-1 as a potential therapeutic target for POCD.

语种英语
WOS记录号WOS:000435394000031
通讯作者邮箱puthmzk@163.com
第一作者单位Shanghai Univ Med & Hlth Sci, Peoples Hosp East Campus 6, Dept Anesthesiol, Shanghai 200233, Peoples R China ; Peking Univ, Dept Anesthesiol, Hosp 3, 49 North Garden St, Beijing 100191, Peoples R China
通讯作者单位Peking Univ, Dept Anesthesiol, Hosp 3, 49 North Garden St, Beijing 100191, Peoples R China
ISSN1791-2997
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/142236
专题北京大学第三临床医学院_麻醉科
作者单位1.North Minzu Univ, Dept Med Imaging, Ningxia 750021, Peoples R China;
2.Shanghai Univ Med & Hlth Sci, Peoples Hosp East Campus 6, Dept Anesthesiol, Shanghai 200233, Peoples R China;
3.Peking Univ, Dept Anesthesiol, Hosp 3, 49 North Garden St, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Cao, Yiyun,Li, Zhengqian,Ma, Lijun,et al. Isoflurane-induced postoperative cognitive dysfunction is mediated by hypoxia-inducible factor-1-dependent neuroinflammation in aged rats[J]. MOLECULAR MEDICINE REPORTS,2018,17(6):7730-7736.
APA Cao, Yiyun.,Li, Zhengqian.,Ma, Lijun.,Ni, Cheng.,Li, Lunxu.,...&Guo, Xiangyang.(2018).Isoflurane-induced postoperative cognitive dysfunction is mediated by hypoxia-inducible factor-1-dependent neuroinflammation in aged rats.MOLECULAR MEDICINE REPORTS,17(6),7730-7736.
MLA Cao, Yiyun,et al."Isoflurane-induced postoperative cognitive dysfunction is mediated by hypoxia-inducible factor-1-dependent neuroinflammation in aged rats".MOLECULAR MEDICINE REPORTS 17.6(2018):7730-7736.
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