IR@PKUHSC  > 北京大学第三临床医学院  > 妇产科
学科主题临床医学
Multidimensional Theranostics for Tumor Fluorescence Imaging, Photoacoustic Imaging and Photothermal Treatment Based on Manganese Doped Carbon Dots
Yang, Chuanyao1,2; Li, Yuan4; Yang, Yanxue5; Tong, Rongsheng1,2; He, Lin1,2,5; Long, Enwu1,2; Liang, Lin3; Cai, Lulu1,2
通讯作者Tong, Rongsheng(1,2) ; Liang, Lin(3) ; Cai, Lulu(1,2)
关键词Carbon Dots Triple Negative Breast Cancer Fluorescence Imaging Photoacoustic Imaging Photothermal Therapy
刊名JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
2018-09-01
DOI10.1166/jbn.2018.2565
14期:9页:1590-1600
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nanoscience & Nanotechnology ; Materials Science, Biomaterials
研究领域[WOS]Science & Technology - Other Topics ; Materials Science
关键词[WOS]GRAPHENE QUANTUM DOTS ; ONE-STEP SYNTHESIS ; BREAST-CANCER ; PHOTOLUMINESCENCE MECHANISM ; GENE DELIVERY ; IN-VIVO ; NANOSPHERES ; NANODOTS ; NANOPARTICLES ; DIAGNOSIS
英文摘要

Multidimensional theranostics have received a lot of attention because of their improved diagnostic accuracy and therapeutic diversity. In this study, we developed a kind of manganese doped nigrosine originated carbon dots (Mn-NCDs), with the average particle size of approximate 3 nm and the long emission wavelength of 653 nm. In vitro experiment demonstrated that Mn-NCDs could be well internalized by 4T1 cells, and the temperature of Mn-NCDs solution could rapidly rise from 23.1 degrees C to more than 50 degrees C when exposed to NIR laser, thus it could generate enough hyperthermia to efficiently destroy 4T1 cells. Furthermore, the in vivo fluorescent and photoacoustic imaging studies highlighted the applicability of Mn-NCDs in dual-mode tumor diagnosis. The prepared Mn-NCDs with long emission wavelength and photothermal anti-cancer effect exhibited great potential for dual-mode imaging and treatment of triple negative breast cancer.

语种英语
WOS记录号WOS:000437426600006
通讯作者邮箱daisylin3916@163.com ; 1505855365@qq.com
第一作者单位Univ Elect Sci & Technol China, Sichuan Acad Med Sci, Personalized Drug Therapy Key Lab Sichuan Prov, Chengdu 610072, Sichuan, Peoples R China ; Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sch Med, Chengdu 610072, Sichuan, Peoples R China
通讯作者单位Univ Elect Sci & Technol China, Sichuan Acad Med Sci, Personalized Drug Therapy Key Lab Sichuan Prov, Chengdu 610072, Sichuan, Peoples R China ; Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sch Med, Chengdu 610072, Sichuan, Peoples R China ; Shanghai Univ Med & Hlth Sci, Affiliated Peoples Hosp 6, South Campus, Shanghai 201499, Peoples R China
ISSN1550-7033
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/142255
专题北京大学第三临床医学院_妇产科
作者单位1.Univ Elect Sci & Technol China, Sichuan Acad Med Sci, Personalized Drug Therapy Key Lab Sichuan Prov, Chengdu 610072, Sichuan, Peoples R China;
2.Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sch Med, Chengdu 610072, Sichuan, Peoples R China;
3.Shanghai Univ Med & Hlth Sci, Affiliated Peoples Hosp 6, South Campus, Shanghai 201499, Peoples R China;
4.Peking Univ, Hosp 3, Gynecol & Obstet Dept, Beijing 100191, Peoples R China;
5.Southwest Jiaotong Univ, Coll Life Sci & Engn, Chengdu 610031, Sichuan, Peoples R China
推荐引用方式
GB/T 7714
Yang, Chuanyao,Li, Yuan,Yang, Yanxue,et al. Multidimensional Theranostics for Tumor Fluorescence Imaging, Photoacoustic Imaging and Photothermal Treatment Based on Manganese Doped Carbon Dots[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2018,14(9):1590-1600.
APA Yang, Chuanyao.,Li, Yuan.,Yang, Yanxue.,Tong, Rongsheng.,He, Lin.,...&Cai, Lulu.(2018).Multidimensional Theranostics for Tumor Fluorescence Imaging, Photoacoustic Imaging and Photothermal Treatment Based on Manganese Doped Carbon Dots.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,14(9),1590-1600.
MLA Yang, Chuanyao,et al."Multidimensional Theranostics for Tumor Fluorescence Imaging, Photoacoustic Imaging and Photothermal Treatment Based on Manganese Doped Carbon Dots".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 14.9(2018):1590-1600.
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