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学科主题临床医学
Lung IMRT planning with automatic determination of beam angle configurations
Yuan, Lulin1,5; Zhu, Wei2; Ge, Yaorong3; Jiang, Yuliang4; Sheng, Yang1; Yin, Fang-Fang1; Wu, Q. Jackie1
通讯作者Yuan, Lulin(1,5)
关键词IMRT knowledge modeling automatic planning lung cancer beam angle optimization
刊名PHYSICS IN MEDICINE AND BIOLOGY
2018-07-01
DOI10.1088/1361-6560/aac8b4
63期:13
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Engineering ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]MODULATED RADIATION-THERAPY ; STEREOTACTIC BODY RADIOTHERAPY ; ORIENTATION OPTIMIZATION ; CONFORMAL RADIOTHERAPY ; SELECTION ; CANCER ; ALGORITHM ; PLANS ; FEASIBILITY ; CRITERIA
英文摘要

Beam angle configuration is a major planning decision in intensity modulated radiation treatment (IMRT) that has a significant impact on dose distributions and thus quality of treatment, especially in complex planning cases such as those for lung cancer treatment. We propose a novel method to automatically determine beam configurations that incorporates noncoplanar beams. We then present a completely automated IMRT planning algorithm that combines the proposed method with a previously reported OAR DVH prediction model. Finally, we validate this completely automatic planning algorithm using a set of challenging lung IMRT cases. A beam efficiency index map is constructed to guide the selection of beam angles. This index takes into account both the dose contributions from individual beams and the combined effect of multiple beams by introducing a beam-spread term. The effect of the beam-spread term on plan quality was studied systematically and the weight of the term to balance PTV dose conformity against OAR avoidance was determined. For validation, complex lung cases with clinical IMRT plans that required the use of one or more noncoplanar beams were re-planned with the proposed automatic planning algorithm. Important dose metrics for the PTV and OARs in the automatic plans were compared with those of the clinical plans. The results are very encouraging. The PTV dose conformity and homogeneity in the automatic plans improved significantly. And all the dose metrics of the automatic plans, except the lung V-5Gy, were statistically better than or comparable with those of the clinical plans. In conclusion, the automatic planning algorithm can incorporate non-coplanar beam configurations in challenging lung cases and can generate plans efficiently with quality closely approximating that of clinical plans.

语种英语
WOS记录号WOS:000437823200006
通讯作者邮箱lulin.yuan@vcuhealth.org
第一作者单位Virginia Commonwealth Univ Hlth Syst, Dept Radiat Oncol, Richmond, VA 23298 USA ; Duke Univ, Med Ctr, Dept Radiat Oncol, Durham, NC 27710 USA
通讯作者单位Virginia Commonwealth Univ Hlth Syst, Dept Radiat Oncol, Richmond, VA 23298 USA ; Duke Univ, Med Ctr, Dept Radiat Oncol, Durham, NC 27710 USA
ISSN0031-9155
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/142263
专题北京大学第三临床医学院_肿瘤放疗科
作者单位1.Duke Kunshan Univ, Kunshan 215316, Jiangsu, Peoples R China;
2.Univ North Carolina Charlotte, Dept Software & Informat Syst, Charlotte, NC 28223 USA;
3.Peking Univ, Hosp 3, Dept Radiat Oncol, Beijing 100191, Peoples R China;
4.Virginia Commonwealth Univ Hlth Syst, Dept Radiat Oncol, Richmond, VA 23298 USA;
5.Duke Univ, Med Ctr, Dept Radiat Oncol, Durham, NC 27710 USA
推荐引用方式
GB/T 7714
Yuan, Lulin,Zhu, Wei,Ge, Yaorong,et al. Lung IMRT planning with automatic determination of beam angle configurations[J]. PHYSICS IN MEDICINE AND BIOLOGY,2018,63(13).
APA Yuan, Lulin.,Zhu, Wei.,Ge, Yaorong.,Jiang, Yuliang.,Sheng, Yang.,...&Wu, Q. Jackie.(2018).Lung IMRT planning with automatic determination of beam angle configurations.PHYSICS IN MEDICINE AND BIOLOGY,63(13).
MLA Yuan, Lulin,et al."Lung IMRT planning with automatic determination of beam angle configurations".PHYSICS IN MEDICINE AND BIOLOGY 63.13(2018).
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