IR@PKUHSC  > 北京大学第九临床医学院
学科主题临床医学
miR-455-3p functions as a tumor suppressor in colorectal cancer and inhibits cell proliferation by targeting TPT1
Sun, Yuanyuan1; Wang, Yan2; Yang, Hainan3; Xu, Yan2; Yu, Haipeng2
通讯作者Yu, Haipeng(2)
关键词miR-455-3p TPT1 colorectal cancer proliferation cell cycle
刊名INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
2018
11期:5页:2522-2529
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Pathology
研究领域[WOS]Oncology ; Pathology
关键词[WOS]MICRORNAS ; CARCINOMA ; PROTEIN ; MIGRATION ; SURVIVAL ; INVASION
英文摘要

increasing studies have revealed the importance of microRNAs (miRNAs) in tumorigenesis and tumor progression. miR-455-3p is a newly identified tumor suppressive RNA in various human cancers. However, the expression pattern and clinical significance of miR-455-3p in colorectal cancer (CRC) remains unclear. We found that expression of miR-455-3p was significantly reduced in CRC tissues and cell lines. In addition, we show that low miR-455-3p expression is associated with larger tumor size, advanced tumor stage, and poorer overall survival of CRC patients. Furthermore, in vitro experiments revealed that overexpression of miR-455-3p represses cell proliferation. Importantly, we show that the tumor protein translationally controlled 1 (TPT1) is a direct target of miR-455-3p. Moreover, expression of TPT1 was inversely correlated with the expression of miR-455-3p. Loss-of-function of TPT1 had a similar effect on CRC cell proliferation in vitro as gain-of-function of miR-455-3p. Taken together, these data suggest that miR-455-3p functions as tumor suppressive RNA by targeting TPT1 in CRC, and it might be a potential therapeutic target for CRC patients.

语种英语
WOS记录号WOS:000434023400027
通讯作者邮箱drhaipeng_dit@126.com
ISSN1936-2625
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/142291
专题北京大学第九临床医学院
作者单位1.Capital Med Univ, Beijing Shijitan Hosp, Ctr Canc, Beijing Key Lab Therapeut Canc Vaccines,Dept Med, Beijing, Peoples R China;
2.Tianjin Med Univ, Canc Inst & Hosp, Dept Intervent Therapy, Natl Clin Res Ctr Canc,Key Lab Canc Prevent & The, Huanhuxi Rd, Tianjin 300060, Peoples R China;
3.Peking Univ, Teaching Hosp 9, Beijing Shijitan Hosp, Dept Med Oncol,Beijing Key Lab Therapeut Canc Vac, Beijing, Peoples R China
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GB/T 7714
Sun, Yuanyuan,Wang, Yan,Yang, Hainan,et al. miR-455-3p functions as a tumor suppressor in colorectal cancer and inhibits cell proliferation by targeting TPT1[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2018,11(5):2522-2529.
APA Sun, Yuanyuan,Wang, Yan,Yang, Hainan,Xu, Yan,&Yu, Haipeng.(2018).miR-455-3p functions as a tumor suppressor in colorectal cancer and inhibits cell proliferation by targeting TPT1.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,11(5),2522-2529.
MLA Sun, Yuanyuan,et al."miR-455-3p functions as a tumor suppressor in colorectal cancer and inhibits cell proliferation by targeting TPT1".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 11.5(2018):2522-2529.
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