学科主题临床医学
Diverse endometrial mRNA signatures during the window of implantation in patients with repeated implantation failure
Shi, Cheng1; Han, Hong Jing1; Fan, Li Juan1; Guan, Jing1; Zheng, Xing Bang1; Chen, Xi1; Liang, Rong1; Zhang, Xiao Wei2; Sun, Kun Kun3; Cui, Qing Hua4; Shen, Huan1
通讯作者Cui, Qing Hua(4) ; Shen, Huan(1)
关键词Endometrium implantation in vitro fertilization (IVF)
刊名HUMAN FERTILITY
2018
DOI10.1080/14647273.2017.1324180
21期:3页:183-194
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]GENE-EXPRESSION PROFILES ; ASSISTED REPRODUCTIVE TECHNOLOGY ; HUMAN EMBRYO IMPLANTATION ; PROGESTERONE-RECEPTOR ; TRANSCRIPT PROFILE ; BINDING PROTEIN-1 ; STIMULATED CYCLES ; CANDIDATE GENES ; RECEPTIVITY ; PREGNANCY
英文摘要

High endometrial receptivity in the window of implantation (WOI) is essential for successful implantation. However, a diagnostic tool with high specificity for impaired endometrial receptivity remains to be developed. We collected endometrium specimens during the WOI from patients with RIF and women who conceived after one IVF/ICSI attempt. We conducted mRNA microarray on the samples followed by relevant comparative and functional analysis. Microarray analysis revealed 357 dysregulated mRNAs between the two groups. The majority of these mRNAs were found to encode membrane proteins by Gene Ontology (GO) analysis. The major functional biological pathways associated with the down-regulated mRNAs were cytokine-cytokine receptor interaction, the p53 signalling pathway and the complement and coagulation cascades. Up-regulated mRNAs were found mainly to participate in pathways such as PPAR signalling, hematopoietic cell lineage, phosphatidylinositol signalling system, ECM-receptor interaction and notch signalling. AQP3, DPP4 and TIMP3 whose expression patterns were down-regulated in RIF patients both by microarray and real-time PCR had a high correspondence with previous studies demonstrating that these genes may contribute to the defects in endometrial receptivity in RIF patients. Overall, these RIF-associated mRNAs may help devise new diagnostic tools for endometrial receptivity.

语种英语
WOS记录号WOS:000439885600005
通讯作者邮箱cuiqinghua@bjmu.edu.cn ; shenhuan418@sina.com
第一作者单位Peking Univ, Peking Univ Peoples Hosp, Reprod Med Ctr, Beijing 100044, Peoples R China
通讯作者单位Peking Univ, Peking Univ Peoples Hosp, Reprod Med Ctr, Beijing 100044, Peoples R China ; Peking Univ, Sch Basic Med Sci, Dept Biomed Informat, Beijing 100191, Peoples R China
ISSN1464-7273
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/142485
专题北京大学第二临床医学院_计划生育与生殖医学科
北京大学护理学院_护理学院
北京大学第二临床医学院_妇科
作者单位1.Peking Univ, Peking Univ Peoples Hosp, Reprod Med Ctr, Beijing 100044, Peoples R China;
2.Peking Univ, Peking Univ Peoples Hosp, Dept Urol, Beijing, Peoples R China;
3.Peking Univ Peoples Hosp, Dept Pathol, Beijing, Peoples R China;
4.Peking Univ, Sch Basic Med Sci, Dept Biomed Informat, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Shi, Cheng,Han, Hong Jing,Fan, Li Juan,et al. Diverse endometrial mRNA signatures during the window of implantation in patients with repeated implantation failure[J]. HUMAN FERTILITY,2018,21(3):183-194.
APA Shi, Cheng.,Han, Hong Jing.,Fan, Li Juan.,Guan, Jing.,Zheng, Xing Bang.,...&Shen, Huan.(2018).Diverse endometrial mRNA signatures during the window of implantation in patients with repeated implantation failure.HUMAN FERTILITY,21(3),183-194.
MLA Shi, Cheng,et al."Diverse endometrial mRNA signatures during the window of implantation in patients with repeated implantation failure".HUMAN FERTILITY 21.3(2018):183-194.
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