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学科主题临床医学
MiR-448 downregulates CTTN to inhibit cell proliferation and promote apoptosis in glioma
Su, H. -Y.1; Lin, Z. -Y.2; Peng, W. -C.2; Guan, F.2; Zhu, G. -T.2; Mao, B. -B.2; Dai, B.2; Huang, H.2; Hu, Z. -Q.1
通讯作者Hu, Z. -Q.(1)
关键词MicroRNA miR-448 Glioma Proliferation Apoptosis
刊名EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
2018-06-01
22期:12页:3847-3854
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]CANCER-CELLS ; MIGRATION ; INVASION ; GLIOBLASTOMA ; TARGETS ; CORTACTIN ; GROWTH
英文摘要

OBJECTIVE: miRNAs have been confirmed to be related to cell proliferation and apoptosis. In this study, we detected the potential effect of miR-448 on glioma cell proliferation and apoptosis.

MATERIALS AND METHODS: miR-448 and CTTN expression levels were detected in glioma cell lines with quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR). Cells were transfected with miR-448 mimics and inhibitor by using lipofectamine 2000 respectively. The proliferative ability of transfected cells was detected via methyl thiazolyl tetrazolium (MTT) and cell counting kit-8 (CCK8) assays. Cell apoptosis and cell-cycle were tested using flow cytometry. The regulatory correlation between miR-448 and CTTN was explored by bioinformatics analysis and luciferase reporter assay.

RESULTS: Lower expression of miR-448 and higher level of CTTN were detected in glioma cells. MiR-448 could egulate cell proliferation, cell apoptosis, and cell cycle. CTTN was negatively regulated by miR-448.

CONCLUSIONS: miR-448 downregulates CTTN to inhibit cell proliferation and promote apoptosis in glioma, which indicates a potential therapeutic target of glioma.

语种英语
WOS记录号WOS:000437779900029
通讯作者邮箱neuro07@163.com
第一作者单位Peking Univ, Sch Clin Med 9, Dept Neurol Surg, Beijing, Peoples R China
通讯作者单位Peking Univ, Sch Clin Med 9, Dept Neurol Surg, Beijing, Peoples R China
ISSN1128-3602
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/142517
专题北京大学第九临床医学院
作者单位1.Peking Univ, Sch Clin Med 9, Dept Neurol Surg, Beijing, Peoples R China;
2.Capital Med Univ, Beijing Shijitan Hosp, Dept Neurol Surg, Beijing, Peoples R China
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GB/T 7714
Su, H. -Y.,Lin, Z. -Y.,Peng, W. -C.,et al. MiR-448 downregulates CTTN to inhibit cell proliferation and promote apoptosis in glioma[J]. EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES,2018,22(12):3847-3854.
APA Su, H. -Y..,Lin, Z. -Y..,Peng, W. -C..,Guan, F..,Zhu, G. -T..,...&Hu, Z. -Q..(2018).MiR-448 downregulates CTTN to inhibit cell proliferation and promote apoptosis in glioma.EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES,22(12),3847-3854.
MLA Su, H. -Y.,et al."MiR-448 downregulates CTTN to inhibit cell proliferation and promote apoptosis in glioma".EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES 22.12(2018):3847-3854.
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