学科主题临床医学
Feasibility of using negative ultrasonography results of axillary lymph nodes to predict sentinel lymph node metastasis in breast cancer patients
Chen, Xue; He, Yingjian; Wang, Jiwei; Huo, Ling; Fan, Zhaoqing; Li, Jinfeng; Xie, Yuntao; Wang, Tianfeng; Ouyang, Tao
通讯作者Ouyang, Tao(1)
关键词axillary staging breast cancer receiver operating characteristic sentinel lymph node biopsy ultrasonography
刊名CANCER MEDICINE
2018-07-01
DOI10.1002/cam4.1606
7期:7页:3066-3072
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]CLINICAL-PRACTICE ; ULTRASOUND ; BIOPSY ; ONCOLOGY
英文摘要

Knowledge of the pathology of axillary lymph nodes (ALN) in breast cancer patients is critical for determining their treatment. Ultrasound is the best noninvasive evaluation for the ALN status. However, the correlation between negative ultrasound results and the sentinel lymph nodes (SLN) pathology remains unknown. To test the hypothesis that negative ultrasound results of ALN predict the negative pathology results of SLN in breast cancer patients, we assessed the association between ALN ultrasonography-negative results and the SLN pathology in 3115 patients with breast cancer recruited between October 2010 and April 2016 from a single cancer center, prospective database. Of these patients who met the inclusion criteria, 2317 (74.4%) had no SLN pathological metastasis. In the univariate analysis, other 798 patient with positive SLN tended to be under age 40 and premenopausal, having large tumor sizes (>2cm), higher histological grade of primary tumor, positive hormone receptors, and negative HER-2 status (P<.05 for all). In the multivariate analysis, menstrual status, tumor size, ER status and histological types of primary tumor remained to be independent predictors for SLN pathological metastasis. The area under curve (AUC) was 0.658 (95% CI=0.637-0.679), P>.05. In conclusion, only a 74.4% consistency between ALN ultrasonography-negative results and negative pathological SLN results, although menstrual status, tumor size, histologic subtypes of primary tumor and ER status were found to be statistically independent predictors of positive SLN among patients negative for ALN ultrasonography. Therefore, the present study suggests that negative ultrasound results of ALN do not adequately predict the negative pathology results of SLN in breast cancer patients.

语种英语
WOS记录号WOS:000439494300028
通讯作者邮箱ouyanghongtao@263.net
第一作者单位Peking Univ, Canc Hosp & Inst, Breast Canc Prevent & Treatment Ctr, Key Lab Carcinogenesi & Translat Res,Minist Educ, Beijing, Peoples R China
通讯作者单位Peking Univ, Canc Hosp & Inst, Breast Canc Prevent & Treatment Ctr, Key Lab Carcinogenesi & Translat Res,Minist Educ, Beijing, Peoples R China
ISSN2045-7634
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/142604
专题北京大学临床肿瘤学院_乳腺癌预防治疗中心
作者单位Peking Univ, Canc Hosp & Inst, Breast Canc Prevent & Treatment Ctr, Key Lab Carcinogenesi & Translat Res,Minist Educ, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Chen, Xue,He, Yingjian,Wang, Jiwei,et al. Feasibility of using negative ultrasonography results of axillary lymph nodes to predict sentinel lymph node metastasis in breast cancer patients[J]. CANCER MEDICINE,2018,7(7):3066-3072.
APA Chen, Xue.,He, Yingjian.,Wang, Jiwei.,Huo, Ling.,Fan, Zhaoqing.,...&Ouyang, Tao.(2018).Feasibility of using negative ultrasonography results of axillary lymph nodes to predict sentinel lymph node metastasis in breast cancer patients.CANCER MEDICINE,7(7),3066-3072.
MLA Chen, Xue,et al."Feasibility of using negative ultrasonography results of axillary lymph nodes to predict sentinel lymph node metastasis in breast cancer patients".CANCER MEDICINE 7.7(2018):3066-3072.
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