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Excitation-Contraction Coupling Time is More Sensitive in Evaluating Cardiac Systolic Function
Gao, Juan1,2; Zhu, Min1,2; Yu, Hai-Yi1,2; Wang, Shi-Qiang3; Feng, Xin-Heng1,2; Xu, Ming1,2
通讯作者Xu, Ming(1,2)
关键词Excitation-Contraction Couplings Heart Failure Left Ventricular Dysfunction
刊名CHINESE MEDICAL JOURNAL
2018-08-05
DOI10.4103/0366-6999.237395
131期:15
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]LEFT-VENTRICULAR HYPERTROPHY ; SKELETAL ; MUSCLE
英文摘要

Background: Pressure overload-induced myocardial hypertrophy is a key step leading to heart failure. Previous cellular and animal studies demonstrated that deteriorated excitation-contraction coupling occurs as early as the compensated stage of hypertrophy before the global decrease in left ventricular ejection fraction (LVEF). This study was to evaluate the cardiac electromechanical coupling time in evaluating cardiac systolic function in the early stage of heart failure.

Methods: Twenty-six patients with Stage B heart failure (SBHF) and 31 healthy controls (CONs) were enrolled in this study. M-mode echocardiography was performed to measure LVEF. Tissue Doppler imaging (TDI) combined with electrocardiography (ECG) was used to measure cardiac electromechanical coupling time.

Results: There was no significant difference in LVEF between SBHF patients and CONs (64.23 +/- 8.91% vs. 64.52 +/- 5.90%; P = 0.886). However, all four electromechanical coupling time courses (Qsb: onset of Q wave on ECG to beginning of S wave on TDI, Qst: onset of Q wave on ECG to top of S wave on TDI, Rsb: top of R wave on ECG to beginning of S wave on TDI, and Rst: top of R wave on ECG to top of S wave on TDI) of SBHF patients were significantly longer than those of CONs (Qsb: 119.19 +/- 35.68 ms vs. 80.30 +/- 14.81 ms, P < 0.001; Qst: 165.42 +/- 60.93 ms vs. 129.04 +/- 16.97 ms, P = 0.006; Rsb: 82.43 +/- 33.66 ms vs. 48.30 +/- 15.18 ms, P < 0.001; and Rst: 122.37 +/- 36.66 ms vs. 93.25 +/- 16.72 ms, P 0.001), and the Qsb, Rsb, and Rst time showed a significantly higher sensitivity than LVEF (Rst: P = 0.032; Rsb: P = 0.003; and Qsb: P = 0.004).

Conclusions: The cardiac electromechanical coupling time is more sensitive than LVEF in evaluating cardiac systolic function.

语种英语
WOS记录号WOS:000440011200012
通讯作者邮箱xuminghi@bjmu.edu.cn
第一作者单位Peking Univ, Minist Hlth,Key Lab Cardiovasc Mol Biol & Regulat, Minist Educ,Beijing Key Lab Cardiovasc Receptors, Key Lab Mol Cardiovasc Sci,Dept Cardiol,Hosp 3, Beijing 100191, Peoples R China ; Peking Univ, Minist Hlth,Key Lab Cardiovasc Mol Biol & Regulat, Minist Educ,Beijing Key Lab Cardiovasc Receptors, Key Lab Mol Cardiovasc Sci,Inst Vasc Med,Hosp 3, Beijing 100191, Peoples R China
通讯作者单位Peking Univ, Minist Hlth,Key Lab Cardiovasc Mol Biol & Regulat, Minist Educ,Beijing Key Lab Cardiovasc Receptors, Key Lab Mol Cardiovasc Sci,Dept Cardiol,Hosp 3, Beijing 100191, Peoples R China ; Peking Univ, Minist Hlth,Key Lab Cardiovasc Mol Biol & Regulat, Minist Educ,Beijing Key Lab Cardiovasc Receptors, Key Lab Mol Cardiovasc Sci,Inst Vasc Med,Hosp 3, Beijing 100191, Peoples R China
ISSN0366-6999
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/142634
专题北京大学第三临床医学院_心血管内科
北京大学口腔医学院_特诊科
作者单位1.Peking Univ, Minist Hlth,Key Lab Cardiovasc Mol Biol & Regulat, Minist Educ,Beijing Key Lab Cardiovasc Receptors, Key Lab Mol Cardiovasc Sci,Dept Cardiol,Hosp 3, Beijing 100191, Peoples R China;
2.Peking Univ, Minist Hlth,Key Lab Cardiovasc Mol Biol & Regulat, Minist Educ,Beijing Key Lab Cardiovasc Receptors, Key Lab Mol Cardiovasc Sci,Inst Vasc Med,Hosp 3, Beijing 100191, Peoples R China;
3.Peking Univ, Coll Life Sci, State Key Lab Membrane Biol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Gao, Juan,Zhu, Min,Yu, Hai-Yi,et al. Excitation-Contraction Coupling Time is More Sensitive in Evaluating Cardiac Systolic Function[J]. CHINESE MEDICAL JOURNAL,2018,131(15).
APA Gao, Juan,Zhu, Min,Yu, Hai-Yi,Wang, Shi-Qiang,Feng, Xin-Heng,&Xu, Ming.(2018).Excitation-Contraction Coupling Time is More Sensitive in Evaluating Cardiac Systolic Function.CHINESE MEDICAL JOURNAL,131(15).
MLA Gao, Juan,et al."Excitation-Contraction Coupling Time is More Sensitive in Evaluating Cardiac Systolic Function".CHINESE MEDICAL JOURNAL 131.15(2018).
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