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Association of Adrenergic Receptor alpha 2A (alpha 2A-AR) Gene rs1800544 Polymorphism with Bone Mineral Density and Bone Turnover Markers in an Elderly Chinese Population
Wang, Qi-Fei1; Sun, Zhe2; Zheng, Fan-Rong1; Zhang, Guang-Wu1; Liu, Zheng1
通讯作者Liu, Zheng(1)
关键词Biological Markers Bone Density Osteoporotic Fractures Polymorphism, Single Nucleotide
刊名MEDICAL SCIENCE MONITOR
2018-07-23
DOI10.12659/MSM.908376
24页:5102-5109
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]VITAMIN-D-RECEPTOR ; SINGLE NUCLEOTIDE POLYMORPHISM ; OSTEOPOROTIC FRACTURE ; POSTMENOPAUSAL WOMEN ; RISK ; METAANALYSIS ; VARIANTS ; ADRA2A ; BSMI ; MEN
英文摘要

Background: Adrenergic receptor alpha 2A (alpha 2A-AR) is up-regulated in osteoporotic bone osteoblasts. Previous research demonstrated an association between polymorphism of alpha 2A-AR gene and bone mineral density (BMD) as well as bone turnover markers (BTMs) in the Slovenian population. The present study aimed to investigate the association of rs1800544 polymorphism of alpha 2A-AR gene with BMD and BTMs in the Chinese elderly population with osteoporosis (OP) or with osteoporotic fractures.

Material/Methods: A total of 346 unrelated elderly individuals were recruited in the study. Rs1800544 polymorphism was determined by Snapshot technology. BTMs were determined by electrochemiluminescence. BMDs at lumbar spine (LS) and proximal femur were measured with dual-energy X-ray absorptiometry (DEXA). Hardy-Weinberg equilibrium and distribution of genotype frequencies were verified using the chi-squared test. Analysis of co-variance (ANCOVA) adjusted for confounding factors was performed to explore the relationship of rs1800544 polymorphism with BMD and BTMs in all participants and in subgroups.

Results: The genotype distributions in all subjects and in subgroups conformed to Hardy-Weinberg equilibrium (P>0.1). Distribution of genotype frequencies of subgroups showed no significant differences (P>0.05). Patients with GG genotype in the fracture group had significantly higher serum BTMs level compared with those carrying other genotypes (P<0.05). No significant association between rs1800544 and BTMs was detected in the elderly population with OP. Comparison of BMD at each site in all participants did not show any significant difference in subgroups with CC, CG, and GG genotypes (P>0.05).

Conclusions: Rs1800544 polymorphism is associated with BTMs level in Chinese elderly individuals with osteoporotic fractures, indicating the involvement of genetic variation of alpha 2A-AR gene in bone metabolism.

语种英语
WOS记录号WOS:000439589500001
通讯作者邮箱953997296@qq.com
第一作者单位Peking Univ, Shougang Hosp, Dept Orthoped, Beijing, Peoples R China
通讯作者单位Peking Univ, Shougang Hosp, Dept Orthoped, Beijing, Peoples R China
ISSN1643-3750
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/142645
专题北京大学首钢医院_骨科
北京大学第三临床医学院_医学工程处
作者单位1.Zibo Cent Hosp, Dept Orthoped, Zibo, Shandong, Peoples R China;
2.Peking Univ, Shougang Hosp, Dept Orthoped, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Wang, Qi-Fei,Sun, Zhe,Zheng, Fan-Rong,et al. Association of Adrenergic Receptor alpha 2A (alpha 2A-AR) Gene rs1800544 Polymorphism with Bone Mineral Density and Bone Turnover Markers in an Elderly Chinese Population[J]. MEDICAL SCIENCE MONITOR,2018,24:5102-5109.
APA Wang, Qi-Fei,Sun, Zhe,Zheng, Fan-Rong,Zhang, Guang-Wu,&Liu, Zheng.(2018).Association of Adrenergic Receptor alpha 2A (alpha 2A-AR) Gene rs1800544 Polymorphism with Bone Mineral Density and Bone Turnover Markers in an Elderly Chinese Population.MEDICAL SCIENCE MONITOR,24,5102-5109.
MLA Wang, Qi-Fei,et al."Association of Adrenergic Receptor alpha 2A (alpha 2A-AR) Gene rs1800544 Polymorphism with Bone Mineral Density and Bone Turnover Markers in an Elderly Chinese Population".MEDICAL SCIENCE MONITOR 24(2018):5102-5109.
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