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Transcriptome-wide analysis of alternative mRNA splicing signature in the diagnosis and prognosis of stomach adenocarcinoma
Shi, Yu1; Chen, Zuhua2; Gao, Juanjuan3; Wu, Si3; Gao, Haer3; Feng, Guoshuang4
通讯作者Feng, Guoshuang(4)
关键词alternative mRNA splicing gastric cancer cancer-specific survival prognosis
刊名ONCOLOGY REPORTS
2018-10-01
DOI10.3892/or.2018.6623
40期:4页:2014-2022
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]RIBOSOMAL-PROTEIN S6 ; GASTRIC-CANCER ; CARCINOGENESIS ; IDENTIFICATION ; VISUALIZATION ; METHYLATION ; MECHANISMS ; EXPRESSION ; CARCINOMA ; BIOMARKER
英文摘要

Alternative mRNA splicing (AS) contributes greatly to expanding the diversity and function of the proteome. Increasing evidence has suggested that dysregulation of mRNA splicing may be associated with various types of cancer. In the present study, RNA sequencing data were used to investigate alterations to the global mRNA splicing landscape of cellular genes from 452 stomach adenocarcinoma (STAD) tissues available in The Cancer Genome Atlas. Seven types of AS events, including the profiles of exon skipping events, were analyzed using SpliceSeq software. A total of 60,754 AS events in 10,611 genes were detected, more than half of which were exon skipping events. The AS events were compared between 415 STAD tissues and 37 normal tissues, and 3,895 differentially spliced cancer-specific events were identified. In addition, the association of the AS events with the overall survival of 373 STAD patients was analyzed. Multivariate Cox regression analysis revealed that prognosis prediction models based on the AS events with clinical parameters had an excellent performance in predicting the survival of STAD patients. This study provides a comprehensive portrait of global changes in mRNA splicing signatures that occur in gastric cancer. These results allowed the identification of a core set of AS in gastric cancer and indicated that AS events may serve as prognostic indicators.

语种英语
WOS记录号WOS:000442971200018
通讯作者邮箱glxfgsh@163.com
第一作者单位Capital Med Univ, Beijing Friendship Hosp, Natl Clin Res Ctr Digest Dis, Beijing 100050, Peoples R China
通讯作者单位Capital Med Univ, Natl Ctr Childrens Hlth, Beijing Childrens Hosp, Ctr Clin Epidemiol & Evidence Based Med, South Lishi Rd, Beijing 100045, Peoples R China
ISSN1021-335X
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/142898
专题北京大学临床肿瘤学院_胃肠肿瘤中心
作者单位1.Capital Med Univ, Beijing Friendship Hosp, Natl Clin Res Ctr Digest Dis, Beijing 100050, Peoples R China;
2.Peking Univ, Canc Hosp & Inst, Dept Gastrointestinal Oncol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China;
3.Peking Univ, Canc Hosp & Inst, Dept Canc Epidemiol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China;
4.Capital Med Univ, Natl Ctr Childrens Hlth, Beijing Childrens Hosp, Ctr Clin Epidemiol & Evidence Based Med, South Lishi Rd, Beijing 100045, Peoples R China
推荐引用方式
GB/T 7714
Shi, Yu,Chen, Zuhua,Gao, Juanjuan,et al. Transcriptome-wide analysis of alternative mRNA splicing signature in the diagnosis and prognosis of stomach adenocarcinoma[J]. ONCOLOGY REPORTS,2018,40(4):2014-2022.
APA Shi, Yu,Chen, Zuhua,Gao, Juanjuan,Wu, Si,Gao, Haer,&Feng, Guoshuang.(2018).Transcriptome-wide analysis of alternative mRNA splicing signature in the diagnosis and prognosis of stomach adenocarcinoma.ONCOLOGY REPORTS,40(4),2014-2022.
MLA Shi, Yu,et al."Transcriptome-wide analysis of alternative mRNA splicing signature in the diagnosis and prognosis of stomach adenocarcinoma".ONCOLOGY REPORTS 40.4(2018):2014-2022.
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