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学科主题临床医学
Upregulation of C/EBP alpha contributes to colorectal cancer growth, metastasis and indicates poor survival outcome
Mi, Lan1,2; Hu, Kai4; Wen, Xianzi1; Sun, Jing3; Wu, Aiwen2; Wang, Mingliang3; Zheng, Minhua3; Zang, Lu3; Ji, Jiafu2
通讯作者Zang, Lu(3) ; Ji, Jiafu(2)
关键词C/EBP alpha colorectal cancer proliferation metastasis EMT
刊名AMERICAN JOURNAL OF CANCER RESEARCH
2018
8期:8页:1449-+
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]BINDING-PROTEIN-ALPHA ; HUMAN HEPATOCELLULAR-CARCINOMA ; CELL-CYCLE ARREST ; C-MYC ; CHROMOSOMAL LOCALIZATION ; EXPRESSION ; PROLIFERATION ; GENE ; TRANSITIONS ; CHECKPOINT
英文摘要

The function and clinical implication of transcription factor CCAAT/enhancer-binding protein a (C/EBPa) in colorectal cancer (CRC) still remains undefined. In fact, C/EBP alpha has long been considered as a tumor suppressor in hematopoietic system and also found lowly expressed in numerous solid tumors. However, our results here for the first time showed that C/EBP alpha was unexpectedly upregulated and was an independent prognostic marker for patients with CRC. We therefore aimed to explore the detailed role and mechanisms of C/EBP alpha in CRC. Our investigation demonstrated that C/EBP alpha promoted tumor growth both in vitro and in vivo. In addition, suppression of C/EBP alpha inhibited cell proliferation by inducing G1 phase arrest and inducing apoptosis. Also, C/EBP alpha enhances CRC cells migration and invasion in vitro as well as metastasis in vivo through regulating EMT. Mechanistically, C/EBP alpha exerts its oncogenic role by targeting c-Myc/cyclin D1 mediated by beta-catenin involved pathway and we provide evidence indicating that cytoplasmic exclusion of C/EBP alpha might contribute to its oncogenic function in tumor progression. In conclusion, C/EBP alpha acts as an oncogene in CRC and could be a potential biomarker of colon carcinogenesis.

语种英语
WOS记录号WOS:000443206500009
通讯作者邮箱luzang_sjtu@163.com ; jiafuj@hotmail.com
第一作者单位Peking Univ, Canc Hosp & Inst, Gastrointestinal Canc Translat Res Lab, Key Lab Carcinogenesis & Translat Res,Minist Educ, 52 Fucheng Rd, Beijing 100142, Peoples R China ; Peking Univ, Canc Hosp & Inst, Dept Gastrointestinal Surg, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing, Peoples R China
通讯作者单位Peking Univ, Canc Hosp & Inst, Dept Gastrointestinal Surg, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing, Peoples R China ; Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Gen Surg, Shanghai, Peoples R China
ISSN2156-6976
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/142924
专题北京大学临床肿瘤学院_胃肠肿瘤中心
北京大学临床肿瘤学院_胃肠肿瘤中心一病区
作者单位1.Peking Univ, Canc Hosp & Inst, Gastrointestinal Canc Translat Res Lab, Key Lab Carcinogenesis & Translat Res,Minist Educ, 52 Fucheng Rd, Beijing 100142, Peoples R China;
2.Peking Univ, Canc Hosp & Inst, Dept Gastrointestinal Surg, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing, Peoples R China;
3.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Gen Surg, Shanghai, Peoples R China;
4.Univ Hosp Heidelberg, European Pancreas Ctr EPZ, Dept Gen Visceral & Transplantat Surg, Heidelberg, Germany
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Mi, Lan,Hu, Kai,Wen, Xianzi,et al. Upregulation of C/EBP alpha contributes to colorectal cancer growth, metastasis and indicates poor survival outcome[J]. AMERICAN JOURNAL OF CANCER RESEARCH,2018,8(8):1449-+.
APA Mi, Lan.,Hu, Kai.,Wen, Xianzi.,Sun, Jing.,Wu, Aiwen.,...&Ji, Jiafu.(2018).Upregulation of C/EBP alpha contributes to colorectal cancer growth, metastasis and indicates poor survival outcome.AMERICAN JOURNAL OF CANCER RESEARCH,8(8),1449-+.
MLA Mi, Lan,et al."Upregulation of C/EBP alpha contributes to colorectal cancer growth, metastasis and indicates poor survival outcome".AMERICAN JOURNAL OF CANCER RESEARCH 8.8(2018):1449-+.
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