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学科主题临床医学
Ketogenic diet attenuates oxidative stress and inflammation after spinal cord injury by activating Nrf2 and suppressing the NF-kappa B signaling pathways
Lu, Yao; Yang, Yan-Yan; Zhou, Mou-Wang; Liu, Nan; Xing, Hua-Yi; Liu, Xiao-Xie; Li, Fang
通讯作者Zhou, Mou-Wang(1)
关键词Ketogenic diet Spinal cord injury Nrf2 NF-kappa B signaling pathway Anti-oxidative stress Anti-inflammatory
刊名NEUROSCIENCE LETTERS
2018-09-14
DOI10.1016/j.neulet.2018.06.016
683页:13-18
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]RESPONSE ELEMENT PATHWAY ; STAIRCASE TEST ; METABOLISM ; RATS ; UBIQUITINATION ; INDUCTION ; PROTEIN
英文摘要

Oxidative stress and inflammation are two key secondary pathological mechanisms following spinal cord injury (SCI). Ketogenic diet (KD) and its metabolite beta-hydroxybutyrate have been found to exhibit anti-oxidative and anti-inflammatory properties both in rats with SCI and in healthy rats; however, the underlying mechanisms are not yet fully understood. We investigated the effects of KD on the suppression of oxidative stress and inflammation, activation of nuclear factor-E2 related factor 2 (Nrf2), and inhibition of the nuclear factor-kappa B (NF-kappa B) signaling pathway in rats with SCI. We assessed functional recovery and evaluated the status of oxidative stress and inflammation using tests of superoxide dismutase and myeloperoxidase activity. We further assessed the presence of the proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1 beta), and interferon gamma (IFN-gamma) by ELISA. Western blotting was used to detect Nrf2 and NF-kappa B pathway-associated proteins in spinal cord tissue. Finally, we measured the levels of the NF-kappa B downstream genes TNF-alpha, IL-1 beta, and IFN-gamma by western blotting and real-time quantitative PCR. Following SCI, KD improved functional recovery, attenuated oxidative stress and inflammation, and induced Nrf2 activation. In addition, KD suppressed the NF-kappa B pathway and the expression of TNF-alpha, IL-1 beta, and IFN-gamma. Together, these findings provide new insight into the underlying regulatory mechanisms of KD.

语种英语
WOS记录号WOS:000443785900003
通讯作者邮箱13910092892@163.com
第一作者单位Peking Univ, Hosp 3, Dept Rehabil Med, 49 North Garden Rd, Beijing 100191, Peoples R China
通讯作者单位Peking Univ, Hosp 3, Dept Rehabil Med, 49 North Garden Rd, Beijing 100191, Peoples R China
ISSN0304-3940
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/142949
专题北京大学第三临床医学院_康复医学科
北京大学医学部管理机构_医学部
北京大学第三临床医学院_医学工程处
作者单位Peking Univ, Hosp 3, Dept Rehabil Med, 49 North Garden Rd, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Lu, Yao,Yang, Yan-Yan,Zhou, Mou-Wang,et al. Ketogenic diet attenuates oxidative stress and inflammation after spinal cord injury by activating Nrf2 and suppressing the NF-kappa B signaling pathways[J]. NEUROSCIENCE LETTERS,2018,683:13-18.
APA Lu, Yao.,Yang, Yan-Yan.,Zhou, Mou-Wang.,Liu, Nan.,Xing, Hua-Yi.,...&Li, Fang.(2018).Ketogenic diet attenuates oxidative stress and inflammation after spinal cord injury by activating Nrf2 and suppressing the NF-kappa B signaling pathways.NEUROSCIENCE LETTERS,683,13-18.
MLA Lu, Yao,et al."Ketogenic diet attenuates oxidative stress and inflammation after spinal cord injury by activating Nrf2 and suppressing the NF-kappa B signaling pathways".NEUROSCIENCE LETTERS 683(2018):13-18.
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