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学科主题基础医学
Sleep patterns deteriorate over time in chronic corticosterone-treated rats
Cui, Xiang-Yu; Yang, Guang; Cui, Su-Ying; Cao, Qing; Huang, Yuan-Li; Ding, Hui; Ye, Hui; Zhang, Xue-Qiong; Wang, Zi-Jun; Zhang, Yong-He
通讯作者Zhang, Yong-He(1)
关键词Sleep Depression Corticosterone Locus coeruleus
刊名NEUROSCIENCE LETTERS
2018-08-01
DOI10.1016/j.neulet.2018.06.017
682页:74-78
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]TYROSINE-HYDROXYLASE GENE ; MESSENGER-RNA LEVELS ; LOCUS-COERULEUS ; MAJOR DEPRESSION ; STRESS ; CERULEUS ; DEGENERATION ; INJECTIONS ; BEHAVIORS ; INSOMNIA
英文摘要

Repeated corticosterone (CORT) injections reliably produce depressive-like behavior in rodents. Our previous study showed that sleep parameters were altered in rats after daily injections of CORT for 7 days, and sleep disturbances appeared to be correlated with depressive-like behavior. The aim of the present study was to investigate time-dependent correlations between changes in sleep parameters and the formation of depressive like behavior in rats after more prolonged treatment with CORT. Rats received daily injections of CORT (40 mg/kg, s.c.) for 7, 14, or 21 days. Electroencephalographic recordings were performed to study sleep parameters. The sucrose preference test and forced swim test were performed to evaluate depressive-like behavior. Western blot was used to detect protein levels. Our results showed that 7-day CORT treatment resulted in no significant depressive-like behavior or changes in rapid-eye-movement (REM) sleep. However, the duration of non-REM sleep significantly decreased, tyrosine hydroxylase (TH) levels significantly increased, and glucocorticoid receptor (GR) expression decreased in the locus coeruleus. Treatment with CORT for 14 and 21 days increased depressive-like behavior, enhanced REM sleep, shortened REM sleep latency, decreased TH and GR levels, and increased the levels of the chaperone FK506 binding protein 51 (FKBP51) in the locus coeruleus. These results indicate that the development of depression after chronic CORT treatment may be related to the formation of sleep disorders. Abnormalities of REM sleep may be a characteristic of sleep in models of depression that is induced by chronic CORT administration in rats. The noradrenergic system and GR pathway in the locus coeruleus may be involved in the formation of depression concomitant with sleep disturbances.

语种英语
WOS记录号WOS:000443787700013
通讯作者邮箱zhyh@hsc.pku.edu.cn
第一作者单位Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100191, Peoples R China
通讯作者单位Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100191, Peoples R China
ISSN0304-3940
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/142965
专题北京大学基础医学院_药理学系
北京大学医学部管理机构_医学部
北京大学基础医学院
北京大学第三临床医学院_老年内科
作者单位Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Cui, Xiang-Yu,Yang, Guang,Cui, Su-Ying,et al. Sleep patterns deteriorate over time in chronic corticosterone-treated rats[J]. NEUROSCIENCE LETTERS,2018,682:74-78.
APA Cui, Xiang-Yu.,Yang, Guang.,Cui, Su-Ying.,Cao, Qing.,Huang, Yuan-Li.,...&Zhang, Yong-He.(2018).Sleep patterns deteriorate over time in chronic corticosterone-treated rats.NEUROSCIENCE LETTERS,682,74-78.
MLA Cui, Xiang-Yu,et al."Sleep patterns deteriorate over time in chronic corticosterone-treated rats".NEUROSCIENCE LETTERS 682(2018):74-78.
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