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Successful cisplatin-etoposide chemotherapy- based treatment of a primary small cell neuroendocrine carcinoma of the tonsil with multiple metastases: a case report
Wang, Xing1,2; Chen, Qiming1; Meng, Jian1
通讯作者Meng, Jian(1)
关键词small cell neuroendocrine carcinoma head and neck multiple metastases complete remission
刊名ONCOTARGETS AND THERAPY
2018
DOI10.2147/OTT.S173231
11页:5391-5395
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Oncology
研究领域[WOS]Biotechnology & Applied Microbiology ; Oncology
关键词[WOS]NECK-CANCER ; HEAD ; PET/CT ; TUMORS
英文摘要

Extrapulmonary small cell neuroendocrine carcinoma (SNEC) is an extremely rare and highly malignant tumor with a poor prognosis. Multiple metastases of SNEC are even more rare, and patients with locally advanced and metastatic disease generally face a poor outcome. To date, only a few cases of SNEC have been reported. Here, we describe a rare case of a 70-year-old female patient with SNEC of the tonsil who presented with multiple metastases and had achieved a complete response (CR) of the primary lesion and cervical lymph nodes for more than 1 year after receiving palliative chemotherapy. Initially, the patient presented with a 2-month history of throat pain. Magnetic resonance imaging and computed tomography revealed a soft mass with moderate enhancement on the left tonsil, which was confirmed by incisional aspiration biopsy. She was additionally sent for a positron emission tomography scan to evaluate small metastases in the left cervical lymph node, right lung, multiple mediastinal lymph nodes, and the fourth lumbar (L4) vertebra body metastases. Histopathological examination of the SNEC confirmed a nested, typical endocrine appearance with small round cells containing ovoid-shaped nuclei and high mitotic activity. Immunohistochemically, the tumor cells were positive for cytokeratin 8/18+, synaptophysin+, CD56+, and Ki-67 (>50%). The patient received 6 cycles of cisplatin combined with etoposide and was subsequently placed under close observation (>12 months). To date, she has achieved a CR of the primary lesion and cervical lymph nodes. In summary, we have described a case of successful treatment after chemotherapy for SNEC and have elucidated professional knowledge regarding the relevant aspects of SNEC.

语种英语
WOS记录号WOS:000443464000001
通讯作者邮箱mrocketj@126.com
第一作者单位Southeast Univ, Affiliated Xuzhou Hosp, Coll Med, Dept Oromaxillofacial Head & Neck Surg, 199 South Jiefang St, Xuzhou 221000, Jiangsu, Peoples R China ; Peking Univ, Sch & Hosp Stomatol, Dept Oral Med, Beijing, Peoples R China
通讯作者单位Southeast Univ, Affiliated Xuzhou Hosp, Coll Med, Dept Oromaxillofacial Head & Neck Surg, 199 South Jiefang St, Xuzhou 221000, Jiangsu, Peoples R China
ISSN1178-6930
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/142985
专题北京大学口腔医学院_口腔内科
北京大学临床肿瘤学院_乳腺癌预防治疗中心
作者单位1.Southeast Univ, Affiliated Xuzhou Hosp, Coll Med, Dept Oromaxillofacial Head & Neck Surg, 199 South Jiefang St, Xuzhou 221000, Jiangsu, Peoples R China;
2.Peking Univ, Sch & Hosp Stomatol, Dept Oral Med, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Wang, Xing,Chen, Qiming,Meng, Jian. Successful cisplatin-etoposide chemotherapy- based treatment of a primary small cell neuroendocrine carcinoma of the tonsil with multiple metastases: a case report[J]. ONCOTARGETS AND THERAPY,2018,11:5391-5395.
APA Wang, Xing,Chen, Qiming,&Meng, Jian.(2018).Successful cisplatin-etoposide chemotherapy- based treatment of a primary small cell neuroendocrine carcinoma of the tonsil with multiple metastases: a case report.ONCOTARGETS AND THERAPY,11,5391-5395.
MLA Wang, Xing,et al."Successful cisplatin-etoposide chemotherapy- based treatment of a primary small cell neuroendocrine carcinoma of the tonsil with multiple metastases: a case report".ONCOTARGETS AND THERAPY 11(2018):5391-5395.
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