IR@PKUHSC  > 北京大学第九临床医学院
学科主题临床医学
AG490 reverses phenotypic alteration of dendritic cells by bladder cancer cells
Xiu, Weigang1,2; Ma, Juan1,2; Lei, Ting1,2; Zhang, Man1,3
通讯作者Zhang, Man(1,3)
关键词bladder cancer cell dendritic cell AG490 Janus kinase 2 signal transducer and activator of transcription 3 pathway
刊名ONCOLOGY LETTERS
2018-09-01
DOI10.3892/ol.2018.9028
16期:3页:2851-2856
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]RADICAL CYSTECTOMY ; DIFFERENTIATION
英文摘要

Past studies have confirmed that tumors can impair the function of dendritic cells (DCs) and promote tumor evasion. AG490, a Janus kinase 2/signal transducer and activator of transcription 3 inhibitor, has been shown to induce maturation of DCs and inhibit the growth of tumor cells. In the present study, DCs were generated from healthy human peripheral blood mononuclear cells. On day 5 of culture, the DCs were co-cultured with human bladder cancer pumc-91 cells for 24 h, and then purified using magnetic beads. The maturation of the DCs was induced by lipopolysaccharide. Subsequent to co-culture with pumc-91 cells, the expression of human leukocyte antigen-antigen D related (HLA-DR), cluster of differentiation (CD)86 and CD80 was found to be reduced in the DCs, accompanied by increased production of interleukin (IL)-10, but decreased production of IL-12p70. Furthermore, the DCs co-cultured with pumc-91 inhibited the proliferation of allogeneic T cells. Finally, AG490 restored the expression of HLA-DR, CD86 and CD80. These data identified that bladder cancer cells could inhibit the antigen-presenting function of the DCs and induce anergy in T cells. AG490 may partly reverse this inhibitory effect of bladder cancer cells on DCs, activate immunogenicity and induce the antitumor immunity response of DCs.

语种英语
WOS记录号WOS:000441948400011
通讯作者邮箱zhangman@bjsjth.cn
第一作者单位Capital Med Univ, Beijing Shijitan Hosp, Dept Clin Lab Med, 10 Tieyi Rd, Beijing 100038, Peoples R China ; Peking Univ, Sch Clin Med 9, Beijing Key Lab Urinary Cellular Mol Diagnost, Beijing 100038, Peoples R China
通讯作者单位Capital Med Univ, Beijing Shijitan Hosp, Dept Clin Lab Med, 10 Tieyi Rd, Beijing 100038, Peoples R China ; Peking Univ, Sch Clin Med 9, Dept Clin Lab Med, Beijing 100038, Peoples R China
ISSN1792-1074
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/143013
专题北京大学第九临床医学院
北京大学口腔医学院_人事处
作者单位1.Capital Med Univ, Beijing Shijitan Hosp, Dept Clin Lab Med, 10 Tieyi Rd, Beijing 100038, Peoples R China;
2.Peking Univ, Sch Clin Med 9, Beijing Key Lab Urinary Cellular Mol Diagnost, Beijing 100038, Peoples R China;
3.Peking Univ, Sch Clin Med 9, Dept Clin Lab Med, Beijing 100038, Peoples R China
推荐引用方式
GB/T 7714
Xiu, Weigang,Ma, Juan,Lei, Ting,et al. AG490 reverses phenotypic alteration of dendritic cells by bladder cancer cells[J]. ONCOLOGY LETTERS,2018,16(3):2851-2856.
APA Xiu, Weigang,Ma, Juan,Lei, Ting,&Zhang, Man.(2018).AG490 reverses phenotypic alteration of dendritic cells by bladder cancer cells.ONCOLOGY LETTERS,16(3),2851-2856.
MLA Xiu, Weigang,et al."AG490 reverses phenotypic alteration of dendritic cells by bladder cancer cells".ONCOLOGY LETTERS 16.3(2018):2851-2856.
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