IR@PKUHSC  > 北京大学第九临床医学院
学科主题临床医学
Dissemination of cfr-mediated linezolid resistance among Staphylococcus species isolated from a teaching hospital in Beijing, China
Jian, Jiyong1,2,3; Chen, Liang1,2,3; Xie, Zeqiang1,2,3; Zhang, Man1,2,3
通讯作者Zhang, Man(1,2,3)
关键词Linezolid resistance staphylococci cfr gene ribosomal protein 23S rRNA mutation
刊名JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
2018-09-01
DOI10.1177/0300060518781636
46期:9页:3884-3889
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]RIBOSOMAL-RNA ; METHICILLIN-RESISTANT ; FLORFENICOL RESISTANCE ; ENTEROCOCCUS-FAECIUM ; POSITIVE MRSA ; AUREUS ; GENE ; CHLORAMPHENICOL ; OXAZOLIDINONES ; PLASMID
英文摘要

Objective The aim of the present study was to report the dissemination of cfr and fexA genes mediated by linezolid resistance among Staphylococcus species.

Methods Three methicillin-resistant staphylococci that were collected from a teaching hospital in Beijing were identified as linezolid-resistant. These three staphylococci were Staphylococcus aureus, S. haemolyticus, and S. cohnii. Mutations in domain V of 23S ribosomal RNA, ribosomal proteins, and the cfr, fexA, and optrA genes were analysed.

Results The three isolates had no mutations of 23S ribosomal RNA, but showed mutations in the cfr and fexA genes. Mutations in the gene for ribosomal protein L3, which resulted in the amino acid exchanges Gly108Glu, Ser158Phe, and Asp159Tyr, were identified in S. cohnii X4535.

Conclusions This is the first report of the cfr gene in clinical linezolid-resistant methicillin-resistant S. aureus isolated from Beijing. L3 mutations coupled with the cfr and fexA genes may act synergistically. Potential transmissibility of this agent, even without prior exposure to linezolid, may have serious epidemiological repercussions.

语种英语
WOS记录号WOS:000443978100038
通讯作者邮箱zhangman@bjsjth.cn
第一作者单位Peking Univ, Sch Clin Med 9, Beijing, Peoples R China ; Capital Med Univ, Beijing Shijitan Hosp, Clin Lab Med, Beijing, Peoples R China ; Beijing Key Lab Urinary Cellular Mol Diagnost, Beijing, Peoples R China
通讯作者单位Peking Univ, Sch Clin Med 9, Beijing, Peoples R China ; Capital Med Univ, Beijing Shijitan Hosp, Clin Lab Med, Beijing, Peoples R China ; Beijing Key Lab Urinary Cellular Mol Diagnost, Beijing, Peoples R China
ISSN0300-0605
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/143141
专题北京大学第九临床医学院
北京大学第二临床医学院_泌尿外科
北京大学口腔医学院_人事处
作者单位1.Peking Univ, Sch Clin Med 9, Beijing, Peoples R China;
2.Capital Med Univ, Beijing Shijitan Hosp, Clin Lab Med, Beijing, Peoples R China;
3.Beijing Key Lab Urinary Cellular Mol Diagnost, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Jian, Jiyong,Chen, Liang,Xie, Zeqiang,et al. Dissemination of cfr-mediated linezolid resistance among Staphylococcus species isolated from a teaching hospital in Beijing, China[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2018,46(9):3884-3889.
APA Jian, Jiyong,Chen, Liang,Xie, Zeqiang,&Zhang, Man.(2018).Dissemination of cfr-mediated linezolid resistance among Staphylococcus species isolated from a teaching hospital in Beijing, China.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,46(9),3884-3889.
MLA Jian, Jiyong,et al."Dissemination of cfr-mediated linezolid resistance among Staphylococcus species isolated from a teaching hospital in Beijing, China".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 46.9(2018):3884-3889.
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