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学科主题临床医学
Shortened Activated Partial Thromboplastin Time and Increased Superoxide Dismutase Levels Are Associated with Type 2 Diabetes Mellitus
Fu, Guangzhen1,2; Yan, Yunmeng1,2; Chen, Ling3; Zhang, Man4,5; Ming, Liang1,2
通讯作者Zhang, Man(4,5) ; Ming, Liang(1,2)
关键词Coagulation test Shorter activated partial thromboplastin time superoxide dismutase Type 2 diabetes mellitus
刊名ANNALS OF CLINICAL AND LABORATORY SCIENCE
2018-07-01
48期:4页:469-477
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medical Laboratory Technology
研究领域[WOS]Medical Laboratory Technology
关键词[WOS]OXIDATIVE STRESS ; MACROVASCULAR COMPLICATIONS ; THROMBIN GENERATION ; HYPERGLYCEMIA ; THROMBOEMBOLISM ; PARAMETERS ; ARTERIES ; RUPTURE ; RISK
英文摘要

Background To determine differences in levels of coagulation and superoxide dismutase in normal controls and type 2 diabetes mellitus patients with different stages of glucose control. Methods. Type 2 diabetes mellitus patients were divided into two groups according to their fasting blood glucose (GM1 and GM2) and HbAl c levels (BM1 and BM2). Blood clotting times and levels of serum superoxide dismutase were compared among the three groups. A receiver operating characteristic (ROC) curve was generated to evaluate predictors and determine their sensitivities and specificities. A Pearson correlation analysis was performed on the type 2 diabetes mellitus patients using standard methods to evaluate the association of serum levels of superoxide dismutase and coagulation parameters with certain disease risk factors. A multiple linear stepwise regression analysis was also performed. Results. There is a significant difference in levels of superoxide dismutase (SOD) and activated partial thromboplastin time (APTT) between normal controls and type 2 diabetes patients with varying glucose tolerance statuses (P<0.001). The difference between GM1 and GM2 with respect to APTT was also statistically significant (P=0.048). The area under the ROC for APTT and SOD was 0.705 and 0.707, respectively. An inverse and highly significant correlation was found between APTT and fasting plasma glucose (r =-0.177, P=0.024), and the serum level of SOD was negatively correlated with age (r=-0.309, P<0.001), D-Dimer (r=-0.253, P=0.001) and APTT (r=-0.2, P=0.007). Conclusions. Shorter APTT and increased SOD levels might be useful hemostatic markers in patients with type 2 diabetes mellitus.

语种英语
WOS记录号WOS:000442583100007
通讯作者邮箱mzhang99@aliyun.com ; mingliang3072@163.com
第一作者单位Zhengzhou Univ, Affiliated Hosp 1, Dept Clin Lab, Zhengzhou, Henan, Peoples R China ; Key Clin Lab Henan Prov, Zhengzhou, Henan, Peoples R China
通讯作者单位Zhengzhou Univ, Affiliated Hosp 1, Dept Clin Lab, Zhengzhou, Henan, Peoples R China ; Peking Univ, Sch Clin Med 9, Dept Clin Lab, Beijing, Peoples R China ; Key Clin Lab Henan Prov, Zhengzhou, Henan, Peoples R China ; Capital Med Univ, Shijitan Hosp, Beijing, Peoples R China
ISSN0091-7370
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/143181
专题北京大学第九临床医学院
作者单位1.Zhengzhou Univ, Affiliated Hosp 1, Dept Clin Lab, Zhengzhou, Henan, Peoples R China;
2.Peking Univ, Sch Clin Med 9, Dept Clin Lab, Beijing, Peoples R China;
3.Key Clin Lab Henan Prov, Zhengzhou, Henan, Peoples R China;
4.Jiangyou Peoples Hosp, Dept Clin Lab, Mianyang, Sichuan, Peoples R China;
5.Capital Med Univ, Shijitan Hosp, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Fu, Guangzhen,Yan, Yunmeng,Chen, Ling,et al. Shortened Activated Partial Thromboplastin Time and Increased Superoxide Dismutase Levels Are Associated with Type 2 Diabetes Mellitus[J]. ANNALS OF CLINICAL AND LABORATORY SCIENCE,2018,48(4):469-477.
APA Fu, Guangzhen,Yan, Yunmeng,Chen, Ling,Zhang, Man,&Ming, Liang.(2018).Shortened Activated Partial Thromboplastin Time and Increased Superoxide Dismutase Levels Are Associated with Type 2 Diabetes Mellitus.ANNALS OF CLINICAL AND LABORATORY SCIENCE,48(4),469-477.
MLA Fu, Guangzhen,et al."Shortened Activated Partial Thromboplastin Time and Increased Superoxide Dismutase Levels Are Associated with Type 2 Diabetes Mellitus".ANNALS OF CLINICAL AND LABORATORY SCIENCE 48.4(2018):469-477.
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