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学科主题临床医学
Comparison of spatial chromosomal organization between bone marrow and peripheral blood in acute myeloid leukemia
Tian, Xueli1; Wang, Yanfang2; Liu, Yu1; Yin, Jun1; Chen, Dieyan1; Ke, Xiaoyan2; Ma, Wanyun1,3
通讯作者Ke, Xiaoyan(2) ; Ma, Wanyun(1,3)
关键词acute myeloid leukemia spatial organization bone marrow peripheral blood three-dimensional fluorescence in situ hybridization
刊名ONCOLOGY LETTERS
2018-10-01
DOI10.3892/ol.2018.9228
16期:4页:4656-4662
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]MINIMAL RESIDUAL DISEASE ; TIME QUANTITATIVE PCR ; IN-SITU HYBRIDIZATION ; ACUTE PROMYELOCYTIC LEUKEMIA ; AML 10 TRIAL ; GENE ; INTERPHASE ; SURVIVAL ; RELAPSE ; T(8/21)
英文摘要

Acute myeloid leukemia associated with t(8;21)(q22;q22)/runt related transcription factor (RUNX)1-RUNX1 translocation partner 1 has been reported to exhibit a favorable outcome. The quantitative polymerase chain reaction is a reliable method for assessing minimal residual disease persistence, and peripheral blood (PB) samples are as informative as bone marrow (BM) samples during follow-up monitoring. However, few studies have compared the spatial organization of leukemia-specific chromosomes between BM and PB. In the present study, paired BM and PB samples were extracted from 6 patients with acute myeloid leukaemia-M2 and compared using three-dimensional fluorescence in situ hybridization. Cells were classified into three types: Normal, proximal and malignant. Comparisons of proportions (% of all cells) of different cell types revealed no significant difference between BM and PB samples. The relative radial positions (RRPs; d/R) of chromosomes 8 and 21 were consistent for 2/3 of BM and PB samples. The RRPs of chromosomes in proximal pairs were more interior in nuclei compared with chromosomes in normal pairs for BM and PB samples. The consistency of the spatial organization of chromosomes between BM and PB suggests that PB may be an alternative to BM for research and clinical diagnosis.

语种英语
WOS记录号WOS:000444990700074
通讯作者邮箱xiaoyank@yahoo.com ; mawy@mail.tsinghua.edu.cn
第一作者单位Tsinghua Univ, Dept Phys, State Key Lab Low Dimens Quantum Phys, 30 ShuangQing Rd, Beijing 100084, Peoples R China
通讯作者单位Collaborat Innovat Ctr Quantum Matter, Beijing 100084, Peoples R China ; Tsinghua Univ, Dept Phys, State Key Lab Low Dimens Quantum Phys, 30 ShuangQing Rd, Beijing 100084, Peoples R China ; Peking Univ, Hosp 3, Dept Hematol, 49 North Garden Rd, Beijing 100191, Peoples R China
ISSN1792-1074
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/145539
专题北京大学第三临床医学院_血液内科
作者单位1.Collaborat Innovat Ctr Quantum Matter, Beijing 100084, Peoples R China;
2.Tsinghua Univ, Dept Phys, State Key Lab Low Dimens Quantum Phys, 30 ShuangQing Rd, Beijing 100084, Peoples R China;
3.Peking Univ, Hosp 3, Dept Hematol, 49 North Garden Rd, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Tian, Xueli,Wang, Yanfang,Liu, Yu,et al. Comparison of spatial chromosomal organization between bone marrow and peripheral blood in acute myeloid leukemia[J]. ONCOLOGY LETTERS,2018,16(4):4656-4662.
APA Tian, Xueli.,Wang, Yanfang.,Liu, Yu.,Yin, Jun.,Chen, Dieyan.,...&Ma, Wanyun.(2018).Comparison of spatial chromosomal organization between bone marrow and peripheral blood in acute myeloid leukemia.ONCOLOGY LETTERS,16(4),4656-4662.
MLA Tian, Xueli,et al."Comparison of spatial chromosomal organization between bone marrow and peripheral blood in acute myeloid leukemia".ONCOLOGY LETTERS 16.4(2018):4656-4662.
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