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Genome-wide association study in Guillain-Barre syndrome
Blum, Stefan1; Ji, Ying2,3; Pennisi, David2; Li, Zhixiu2; Leo, Paul2; McCombe, Pamela1; Brown, Matthew A.2
通讯作者Brown, Matthew A.(2)
关键词Guillain-Barre syndrome Case-control study Genome-wide association study Heritability Genetic risk score Human leukocyte antigen (HLA) genes
刊名JOURNAL OF NEUROIMMUNOLOGY
2018-10-15
DOI10.1016/j.jneuroim.2018.07.016
323页:109-114
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Neurosciences
研究领域[WOS]Immunology ; Neurosciences & Neurology
关键词[WOS]DIFFERENTIAL DISTRIBUTION ; MUSCULAR-DYSTROPHY ; ULCERATIVE-COLITIS ; FUTURE-DIRECTIONS ; HLA ANTIGENS ; 2 FORMS ; POLYMORPHISMS ; SUSCEPTIBILITY ; GENETICS ; MUTATION
英文摘要

Guillain-Barre syndrome (GBS) is considered to have an immune-mediated basis, but the genetic contribution to GBS is unclear. We conducted a GWAS involving 215 GBS patients and 1,105 healthy controls. No significant associations of individual SNPs or imputed HLA types were observed. We performed a genome-wide complex trait analysis for evaluation of the heritability of GBS, and found that common SNPs contribute up to 25% of susceptibility to the disease. Genetic risk score analysis showed no evidence of overlap in genetic susceptibility factors of GBS and multiple sclerosis. Given the unexplained heritability of the trait further larger GWAS are indicated.

语种英语
WOS记录号WOS:000445168600016
通讯作者邮箱matt.brown@qut.edu.au
第一作者单位Univ Queensland, UQ Ctr Clin Res, Royal Brisbane & Womens Hosp, Brisbane, Qld, Australia
通讯作者单位QUT, Translat Res Inst, Sch Biomed Sci, Inst Hlth & Biomed Innovat,Translat Genom Grp, Brisbane, Qld, Australia
ISSN0165-5728
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/145544
专题北京大学第三临床医学院_神经内科
作者单位1.Univ Queensland, UQ Ctr Clin Res, Royal Brisbane & Womens Hosp, Brisbane, Qld, Australia;
2.QUT, Translat Res Inst, Sch Biomed Sci, Inst Hlth & Biomed Innovat,Translat Genom Grp, Brisbane, Qld, Australia;
3.Peking Univ, Hosp 3, Dept Neurol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Blum, Stefan,Ji, Ying,Pennisi, David,et al. Genome-wide association study in Guillain-Barre syndrome[J]. JOURNAL OF NEUROIMMUNOLOGY,2018,323:109-114.
APA Blum, Stefan.,Ji, Ying.,Pennisi, David.,Li, Zhixiu.,Leo, Paul.,...&Brown, Matthew A..(2018).Genome-wide association study in Guillain-Barre syndrome.JOURNAL OF NEUROIMMUNOLOGY,323,109-114.
MLA Blum, Stefan,et al."Genome-wide association study in Guillain-Barre syndrome".JOURNAL OF NEUROIMMUNOLOGY 323(2018):109-114.
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