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学科主题临床医学
Cyclic-Arginine-Glycine-Aspartic (c-RGD) Conjugated Polymeric Micelles for SPECT/NIRF Dual-Modality Tumor Imaging
Zhu, Hua1; Xia, Lei1; Xu, Xiaoxia1; Liu, Fei1; Zhao, Jun2; Li, Chun2; Yang, Zhi1
通讯作者Yang, Zhi(1)
关键词Polymeric Micelles SPECT Imaging Fluorescence Optical Imaging c-RGD
刊名JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
2018-11-01
DOI10.1166/jnn.2018.15547
18期:11页:7858-7866
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]RADIATION-DOSIMETRY ; QUANTUM DOTS ; NANOPARTICLES ; PEPTIDE ; INTEGRINS ; BIODISTRIBUTION ; VASCULATURE ; EXPRESSION ; DESIGN
英文摘要

The purpose of this research was to develop a dual modality nanoparticle probe for nuclear and near-infrared fluorescence tomography (NIRF) imaging of tumor integrin alpha v beta 3 expression. c-RGD was conjugated to polyethylene glycol-coated, core-crosslinked polymeric micelles (CCPM) dually labeled with both near-infrared fluorescence fluorophores (Cy7) and a radioisotope (In-111). In vitro, CCPM-RGD was selectively bound to alpha v beta 3 positive human glioma U87 cells, and this uptake could be blocked by an excess amount of c-RGD. In vivo, subcutaneously U87 xenograft tumors were clearly visible by both SPECT and NIRF after intravenous administration of 18.5 MBq In-111 labeled CCPM-RGD. The accumulation of In-111-CCPM-RGD in the U87 tumor could be significantly reduced after co-injection with an excess amount of c-RGD peptide (>95% inhibition). At 72 hrs post injection, the tumor uptake was 5.21 +/- 0.46% of the injected dose per gram of tissue (% ID/g). In-111-labeled CCPM-RGD allowed visualization of cancer cells over expressing alpha v beta 3 by both nuclear and optical techniques.

语种英语
WOS记录号WOS:000443946600078
第一作者单位Peking Univ Canc Hosp & Inst, Dept Nucl Med, Key Lab Carcinogenesis & Translat Res, Minist Educ Beijing, Beijing 100142, Peoples R China
通讯作者单位Peking Univ Canc Hosp & Inst, Dept Nucl Med, Key Lab Carcinogenesis & Translat Res, Minist Educ Beijing, Beijing 100142, Peoples R China
ISSN1533-4880
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/145559
专题北京大学临床肿瘤学院_核医学科
北京大学第一临床医学院_妇产科
作者单位1.Peking Univ Canc Hosp & Inst, Dept Nucl Med, Key Lab Carcinogenesis & Translat Res, Minist Educ Beijing, Beijing 100142, Peoples R China;
2.Univ Texas MD Anderson Canc Ctr, Dept Canc Syst Imaging, Houston, TX 77030 USA
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GB/T 7714
Zhu, Hua,Xia, Lei,Xu, Xiaoxia,et al. Cyclic-Arginine-Glycine-Aspartic (c-RGD) Conjugated Polymeric Micelles for SPECT/NIRF Dual-Modality Tumor Imaging[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2018,18(11):7858-7866.
APA Zhu, Hua.,Xia, Lei.,Xu, Xiaoxia.,Liu, Fei.,Zhao, Jun.,...&Yang, Zhi.(2018).Cyclic-Arginine-Glycine-Aspartic (c-RGD) Conjugated Polymeric Micelles for SPECT/NIRF Dual-Modality Tumor Imaging.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,18(11),7858-7866.
MLA Zhu, Hua,et al."Cyclic-Arginine-Glycine-Aspartic (c-RGD) Conjugated Polymeric Micelles for SPECT/NIRF Dual-Modality Tumor Imaging".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 18.11(2018):7858-7866.
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