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学科主题临床医学
Lugol Chromoendoscopy Detects Esophageal Dysplasia With Low Levels of Sensitivity in a High-Risk Region of China
Li, Jingjing1; Xu, Ruiping2; Liu, Mengfei1; Cai, Hong1; Cao, Changqi3; Liu, Fangfang1; Li, Fenglei4; Guo, Chuanhai1; Pan, Yaqi1; He, Zhonghu1; Ke, Yang1
通讯作者He, Zhonghu(1) ; Ke, Yang(1)
关键词Esophageal Cancer Imaging Early Detection Accuracy
刊名CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
2018-10-01
DOI10.1016/j.cgh.2017.11.031
16期:10页:1585-1592
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]SQUAMOUS-CELL CARCINOMA ; AJCC/UICC STAGING MANUALS ; ESOPHAGOGASTRIC JUNCTION ; ENDOSCOPIC DETECTION ; CANCER STATISTICS ; FOLLOW-UP ; RECOMMENDATIONS ; POPULATION ; NEOPLASIA
英文摘要

BACKGROUND & AIMS: Chromoendoscopy with Lugol dye is used to screen for early-stage esophageal squamous dysplasia (ESD) and esophageal cancer. However, the sensitivity with which Lugol chromoendoscopy detects ESD or esophageal cancer has not been fully assessed in large populations in China.

METHODS: From 2012 to 2016, a total of 15,264 residents in rural Hua County, Henan Province, which is a high-incidence area of esophageal cancer in China, were screened by Lugol chromoendoscopy. Biopsies were collected from endoscopically visualized lesions, identified before and after Lugol chromoendoscopy, and analyzed histologically. Biopsies were also collected from standard sites in the esophagus (28 and 33 cm distal to the incisors) if no abnormalities were found. We calculated the sensitivity with which Lugol chromoendoscopy detects esophageal dysplasia and carcinoma, using findings from biopsy analysis as the reference standard.

RESULTS: A total 586 participants were found by biopsy analysis to have ESD or more severe lesions. After endoscopy images were reviewed twice, Lugol chromoendoscopy sensitivity values for the detection of mild, moderate, and severe dysplasia, and esophageal cancer, were 45.9%, 55.3%, 87.0%, and 97.7%, respectively. ESDs were most frequently missed by Lugol chromoendoscopy in younger patients and men with moderate levels of dysplasia.

CONCLUSION: In a screening analysis of a general population in China, we found Lugol chromoendoscopy to identify individuals with ESD with lower levels of sensitivity (46%-87%) than previously believed, although it identified patients with esophageal cancer with almost 98% sensitivity. Prospective studies are needed to evaluate the clinical significance of esophageal lesions that are not detected by endoscopy.

语种英语
WOS记录号WOS:000445031900017
通讯作者邮箱zhonghuhe@foxmail.com ; keyang@bjmu.edu.cn
第一作者单位Peking Univ Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Lab Genet, Minist Educ Beijing, 52 Fucheng Rd, Beijing 100142, Peoples R China
通讯作者单位Peking Univ Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Lab Genet, Minist Educ Beijing, 52 Fucheng Rd, Beijing 100142, Peoples R China
ISSN1542-3565
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/145560
专题北京大学临床肿瘤学院_中心实验室
作者单位1.Hua Cty Peoples Hosp, Anyang, Henan, Peoples R China;
2.Anyang Canc Hosp, Anyang, Henan, Peoples R China;
3.Peking Univ Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Lab Genet, Minist Educ Beijing, 52 Fucheng Rd, Beijing 100142, Peoples R China;
4.Peking Univ Canc Hosp & Inst, Endoscopy Ctr, Key Lab Carcinogenesis & Translat Res, Minist Educ Beijing, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Li, Jingjing,Xu, Ruiping,Liu, Mengfei,et al. Lugol Chromoendoscopy Detects Esophageal Dysplasia With Low Levels of Sensitivity in a High-Risk Region of China[J]. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY,2018,16(10):1585-1592.
APA Li, Jingjing.,Xu, Ruiping.,Liu, Mengfei.,Cai, Hong.,Cao, Changqi.,...&Ke, Yang.(2018).Lugol Chromoendoscopy Detects Esophageal Dysplasia With Low Levels of Sensitivity in a High-Risk Region of China.CLINICAL GASTROENTEROLOGY AND HEPATOLOGY,16(10),1585-1592.
MLA Li, Jingjing,et al."Lugol Chromoendoscopy Detects Esophageal Dysplasia With Low Levels of Sensitivity in a High-Risk Region of China".CLINICAL GASTROENTEROLOGY AND HEPATOLOGY 16.10(2018):1585-1592.
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