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The association of garlic with Helicobacter pylori infection and gastric cancer risk: A systematic review and meta-analysis
Li, Ziyu; Ying, Xiangji; Shan, Fei; Ji, Jiafu
通讯作者Ji, Jiafu(1)
关键词garlic gastric cancer Helicobacter pylori prevention
刊名HELICOBACTER
2018-10-01
DOI10.1111/hel.12532
23期:5
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Microbiology
研究领域[WOS]Gastroenterology & Hepatology ; Microbiology
关键词[WOS]ALLIUM VEGETABLE INTAKE ; HIGH-EPIDEMIC AREA ; STOMACH CANCERS ; ENVIRONMENTAL-FACTORS ; JIANGSU PROVINCE ; DIETARY FACTORS ; REDUCED RISK ; SERUM LEPTIN ; POPULATION ; ESOPHAGEAL
英文摘要

BackgroundGarlic may be protective against Helicobacter pylori infection and gastric cancer development. We conducted this study to quantitatively update evidence on garlic intake and gastric cancer with the inclusion of most recent cohort studies and qualitatively summarize epidemiological studies of garlic consumption and Helicobacter pylori infection.

Materials and MethodsPubMed, Embase, MEDLINE, and Cochrane Library were searched on April 2018. We conducted a meta-analysis to determine whether garlic intake reduced gastric cancer risk using random-effect models and a systematic review to summarize evidence on the association between garlic consumption and Helicobacter pylori infection. Risk of bias was assessed using tools of Cochrane risk of bias and Robins-I for randomized and nonrandomized studies, respectively.

ResultsMeta-analysis of 18 studies (142921 subjects) demonstrated high garlic consumption (as comparing the highest category to the lowest) was associated with a reduced gastric cancer risk (OR=0.51, 95% CI=0.44-0.57). This association became nonsignificant if only derived from the prospective studies (OR=0.95, 95% CI=0.66-1.24). Thirteen studies (4889 participants) were included in the systematic review for garlic consumption and Helicobacter pylori infection; ten of which found no significant results. The majority of these studies were poor in quality given the small sample size and high risk of bias.

ConclusionsPooled evidence, mainly from case-control studies, suggested a significant inverse association of garlic intake with gastric cancer risk. Given the limitations of included studies, current epidemiological evidence is not sufficient to reach any definite conclusion regarding the association of garlic with Helicobacter pylori infection.

语种英语
WOS记录号WOS:000445184300006
通讯作者邮箱jijiafu@hsc.pku.edu.cn
第一作者单位Peking Univ, Canc Hosp & Inst, Gastrointestinal Canc Ctr, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing, Peoples R China
通讯作者单位Peking Univ, Canc Hosp & Inst, Gastrointestinal Canc Ctr, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing, Peoples R China
ISSN1083-4389
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/145564
专题北京大学临床肿瘤学院_胃肠肿瘤中心
北京大学临床肿瘤学院_胃肠肿瘤中心一病区
作者单位Peking Univ, Canc Hosp & Inst, Gastrointestinal Canc Ctr, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Li, Ziyu,Ying, Xiangji,Shan, Fei,et al. The association of garlic with Helicobacter pylori infection and gastric cancer risk: A systematic review and meta-analysis[J]. HELICOBACTER,2018,23(5).
APA Li, Ziyu,Ying, Xiangji,Shan, Fei,&Ji, Jiafu.(2018).The association of garlic with Helicobacter pylori infection and gastric cancer risk: A systematic review and meta-analysis.HELICOBACTER,23(5).
MLA Li, Ziyu,et al."The association of garlic with Helicobacter pylori infection and gastric cancer risk: A systematic review and meta-analysis".HELICOBACTER 23.5(2018).
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